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Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabo

The use of drones in the spatial social sciences

Drones are increasingly becoming a ubiquitous feature of society. They are being used for a multiplicity of applications for military, leisure, economic, and academic purposes. Their application in academia, especially as social science research tools, has seen a sharp uptake in the last decade. This has been possible due, largely, to significant developments in computerization and miniaturization

Location and characterization of the three carbohydrate prosthetic groups of human protein HC

Three different carbohydrate prosthetic groups associated to three chymotryptic peptides, Q1, Q2 and Q3, were isolated from the reduced and carboxymethylated human protein HC. The first oligosaccharide forms an O-glycosidic linkage with a threonine residue at position 5 in the polypeptide chain of protein HC. The second and third carbohydrate prosthetic groups form N-linkages with asparagine resid

The epigenesis of meaning in human beings, and possibly in robots

This article addresses a classical question: Can a machine use language meaningfully and if so, how can this be achieved? The first part of the paper is mainly philosophical. Since meaning implies intentionality on the part of the language user, artificial systems which obviously lack intentionality will be `meaningless' (pace e.g. Dennett). There is, however, no good reason to assume that intenti

Groundwater pollution sources apportionment in the ghaen plain, Iran

Although Iran’s Ghaen Plain provides saffron to much of the world, no regional groundwater quality (GQ) assessment has yet been undertaken. Given the region’s potential for saltwater intrusion and heavy metal contamination, it is important to assess the GQ and determine its main probable source of pollution (MPSP). Such knowledge would allow for informed mitigation or elimination of the potential

The Meaning of Being a Living Kidney, Liver, or Stem Cell Donor - A Meta-Ethnography

Background Studies on living donors from the donors' perspective show that the donation process involves both positive and negative feelings involving vulnerability. Qualitative studies of living kidney, liver, and allogeneic hematopoietic stem cell donors have not previously been merged in the same analysis. Therefore, our aim was to synthesize current knowledge of these donors' experiences to de

Yet another kinetic mechanism for hydrogen combustion

Recent suggestion by Burke and Klippenstein (2017) that chemically termolecular reactions H + O2 + R may significantly affect kinetic pathways under common combustion situations requires careful analysis, since, if included in contemporary kinetic mechanisms, these reactions affect global reactivity and calculated burning velocities of laminar premixed flames. In the view of their impact, a detail

Sick of squabbling? Household division of labor, disagreement, and ill-health among partnered men and women in Sweden 2000-2010

Individual health and work are closely connected in both positive and negative ways. We investigate the impacts of paid work, unpaid work, and the perception of how work is shared, on subjective and objective health measures in contemporary Sweden. We focus on how gender, workload, and disagreement shape health impacts among partnered men and women. We perform multivariate regression analysis on d

Corneal endothelial morphology and central thickness in patients with type II diabetes mellitus

PURPOSE: To investigate corneal endothelial cell density and morphology in type II diabetic and non-diabetic patients and to relate potential differences to the glycaemic status.METHODS: A prospective clinical study including 107 patients with type II diabetes and 128 non-diabetic patients. Sample size was based on a power calculation (power = 0.90; p = 0.05). The diabetic patients had on average

Bioadaptor implant versus contemporary drug-eluting stent in percutaneous coronary interventions in Sweden (INFINITY-SWEDEHEART) : a single-blind, non-inferiority, registry-based, randomised controlled trial

Background: Persistent non-plateauing adverse event rates in patients who underwent percutaneous coronary intervention (PCI) remain a challenge. A bioadaptor is a novel implant that addresses this issue by restoring the haemodynamic modulation of the artery, allowing cyclic pulsatility, vasomotion, and adaptative remodelling, by unlocking and providing dynamic support to the artery. We aimed to as

Buxus sempervirens and Laurus nobilis leaves from an archaeological site at 7300 cal BP (La Draga, Spain) provide a better understanding of past vegetation and human activities

Leaves are valuable, but very rare, remains in archaeological contexts, as they can provide precise information on the landscape vegetation composition, the past climatic conditions and the use of plant resources in a settlement. La Draga (Spain) is an early Neolithic site partially waterlogged, which has allowed the preservation of organic material. During the excavation of the oldest level (7300

Characteristics of MILD combustion of CH4-CO2 jets in a piloted burner – Laser-diagnostic and LES studies

Fundamental characteristics of the reaction-zone structure for CH4-CO2 jets, mimicking a fuel of high CO2 contents such as biogas, burning in a heated coflow on a piloted jet burner have been investigated. Jet flames under diffusion and MILD combustion conditions were studied using planar laser-induced fluorescence (PLIF) of O-atom radicals and CO for different CO2 contents of the fuel jet. Numeri

Psychometric properties of the Swedish version of the SNAP-IV rating scale parent form in a birth cohort of 11-year-old children

OBJECTIVE: The primary aim of this study was to confirm the internal consistency and factor structure of the Swedish version of the Swanson-Nolan-Pelham scale fourth edition (SNAP-IV) for parents and to examine its clinical utility for identifying children diagnosed with attention deficit/hyperactivity disorder (ADHD).MATERIALS AND METHODS: Parents of 11-year-old children from a birth cohort in th

Prediction of individuals at high absolute risk of esophageal squamous cell carcinoma

BACKGROUND AND AIMS: This study aimed to develop a prediction model for identifying individuals at high absolute risk of esophageal squamous cell carcinoma (ESCC) for endoscopic screening at a curable stage based on readily identifiable risk factors.METHODS: This was a nationwide Swedish population-based, case-control study, including 167 new cases of ESCC and 820 randomly selected control partici

Tetrabromobenzene-based molecular alloys - a tool for tailoring the temperature of the thermosalient phase transition

A series of molecular alloys of 1,2,4,5-tetrabromobenzene and 1,2,4,5-tetrachlorobenzene with varying compositions were prepared in an attempt to obtain jumping crystals with adjustable temperature of thermosalient phase transition. Molecular alloys were studied with a combination of thermal and structural techniques (DSC, SCXRD, XRPD, hot-stage microscopy). Alloys with a high 1,2,4,5-tetrabromobe

Theorizing the processes and practices of entrepreneuring at work

As the boundaries of ‘work’ extend to include work that adapts to or brings about new organization, social value and alternative futures, it intersects with entrepreneurship studies in intriguing yet under-developed ways. This special issue focuses on developing this intersection by advancing process and practice theory research on entrepreneuring. Entrepreneuring is a concept that captures the pr

A review of the potential impacts of climate change on the safety and performance of bridges

An overabundance of evidence, both observational and from model projections, indicate that changes to the climate system are taking place at unprecedented rates. Although the magnitudes of these changes involve large uncertainties, the fact that our climate is changing is unequivocal. To ensure an unimpaired functionality of our societies,it is therefore of crucial importance to study the potentia

An analysis of pool boiling heat transfer on nanoparticle-coated surfaces

In the present study, copper surfaces were deposited with Cu-Zinc nanoparticles of 0.6 mg by an electrophoretic deposition method (EPD). Two deposition patterns were designed, i.e., fully deposition (EPD-F) and channel-pattern deposition (EPD-C). In the channel-pattern deposition, the smooth channel and the deposition channel occur alternatively, by keeping the width of the smooth channel as 3 mm,