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Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain. The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical. Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larg
PURPOSE: Randomized multiple myeloma (MM) studies show improved response rates and better progression-free survival for newer therapies. However, a less pronounced effect has been found for overall survival (OS). Using population-based data including detailed treatment information for individual patients, we assessed survival patterns for all patients diagnosed with MM in Malmö, Sweden from 1950 t
Migratory birds use multiple sources of compass information for orientation, including the geomagnetic field, the sun, skylight polarization patterns and star patterns. In this paper we review the results of cue-conflict experiments designed to determine the relative importance of the different compass mechanisms, and how directional information from these compass mechanisms is integrated. We focu
Although dic(9;20)(p13.2;q11.2) is a characteristic abnormality in childhood B-cell precursor acute lymphoblastic leukemias (BCP ALL), little is known about its clinical impact or the type and frequency of additional aberrations it may occur together with. We here review the clinical and cytogenetic features of a Nordic pediatric series of 24 patients with dic(9;20)-positive BCP ALL diagnosed 1996
The DyDOC model simulates the C dynamics of forest soils, including the production and transport of dissolved organic matter (DOM), on the basis of soil hydrology, metabolic processes, and sorption reactions. The model recognizes three main pools of soil C: litter, substrate (an intermediate transformation product), and humic substances. The model was used to simulate the behavior of C in the 0 ho
Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and
Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in
Context: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. Objective: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these
Benign fibrous histiocytoma (BFH) is a mesenchymal tumor that most often occurs in the skin (so-called dermatofibroma), but may also appear in soft tissues (so-called deep BFH) and in the skeleton (so-called non-ossifying fibroma). The origin of BFH is unknown, and it has been questioned whether it is a true neoplasm. Chromosome banding, fluorescence in situ hybridization, single nucleotide polymo
The COP 15 of the UN Convention on Biological Diversity emphasised the need to monitor, evaluate, and disclose the risks and dependencies of financial institutions on biodiversity. In the light of this context, our paper focuses specifically on banks and is framed by the following overarching question: to what extent have banks identified, integrated, measured, and disclosed their dependency and e
BACKGROUND: Beneficial effects from practising a Paleolithic diet as compared to a diabetes diet on weight, waist circumference, satiety, leptin, HbA1c and glucose control in randomised controlled trial participants with type 2 diabetes could be due to lower leptin resistance. Support for this hypothesis comes from an in vitro experiment that showed that digested wheat gluten, which is excluded fr
BACKGROUND: In Bangladesh, diarrhoea in children under-five is a major public health problem with cost implications. Although under-five diarrhoea mortality and morbidity have declined from 2007 to 2018, change in the economic burden is unknown. This study determined the change in the societal economic burden of under-five diarrhoea in Bangladesh comparing 2007 to 2018.METHODS: A prevalence-based,
Säkerhetspolisen har idag möjlighet att enligt lag (1991:572) om särskild utlänningskontroll ansöka om utvisning av en utlänning som anses hota rikets säkerhet. Dessa ärenden kallas för kvalificerade säkerhetsärenden. Utvisningsförfarandet enligt denna särskilda lag har dock kritiserats för brister i rättssäkerheten, bland annat till följd av den begränsade partsinsynen och den avvikande instansorThe Swedish Security Service has the possibility to apply for expulsion of a foreigner who is considered a threat to the national security in accordance with The Special Controls of Aliens Act (1991:572). These cases are called high-level security cases. However, the expulsion procedure under this special law has been criticized for the lack of legal security. The purpose of this paper has been to
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Adaptive immunity has been implicated in cardiovascular diseases, but the relationship between immune capacity or immune function in these diseases has yet to be established. I optimized a method to screen for immune capacity using immune responsiveness against the SARS-CoV-2 spike protein as a proxy. This method screens for markers upregulated during activation on lymphocytes using fluorescent an
Grey Cast iron is an Iron Carbon alloy and is known for its wide range of applications in manufacturing industry. It contains inclusions such as Manganese, silicon, nickel, vanadium and copper. Traces of impurities such as sulphur and phosphorous are also present which is one of the factors affecting Machinability leading to unpredictable process behavior. This Master’s degree thesis is an Indust
Ett förändrat omvärldsläge med en mångfald av globala utmaningar har satt strålkastarljuset på riskkommunikation. Det ansvaret faller till stor del på våra offentliga myndigheter, vars syfte är att förbereda och skydda allmänheten. Men hur väl når deras budskap ut? Denna fråga är särskilt relevant för unga vuxna, som har mindre erfarenhet av kriser men samtidigt är framtidens generation och därförA changing environment with a multitude of global challenges has put the spotlight on risk communication. This responsibility falls largely on our public authorities, whose purpose is to prepare and protect the public. But how well do they get their message across? This question is particularly relevant for young adults, who have less experience of crises but are the generation of the future and t
