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Summary. This review describes the background for the development of recombinant FVIIa (rFVIIa; NovoSeven) for use in haemophilic patients with inhibitors. The first proof of principle for using pharmacological doses of FVIIa as a haemostatic agent was obtained by producing small amounts of pure plasma-derived FVIIa, which showed encouraging effect in two patients with haemophilia A and inhibitors
Plastic and reconstructive surgery has had a long history with international humanitarian efforts. As the field of global surgery continues to gain momentum in academic centers throughout the world, the role of the surgical subspecialist in the public health infrastructure of low-resource communities has also begun to gain a new sense of wonder and importance. Arthur Barsky, Jr was arguably one of
Hippuric acid has been a major human metabolite for years. However, there is no well-known documented health benefit associated with it except for excretion of environmental-toxic exposures of aromatic compounds such as toluene, or from dietary protein degradation and re-synthesis by intestinal microflora metabolism of quinic acid via the shikimate pathway. Thus hippuric acid can appear in humans
Background and aim - The development of clinical manifectations due to an eroded or ruptured atherosclerotic plaque, or occluded vessel, are one of the major causes of death world wide. It has been known for some time that atherosclerosis develops due to retention and modification of LDL particles in the vessel wall and the subsequent triggering of the immune system. The research presented within
Fåglar har relativt stora ögon för sina kroppsstorlekar och syn är en kostsam sinnesförmåga, speciellt för flygande djur eftersom stora ögon medför extra vikt. Man kan därför anta att fåglar använder synen för viktiga beteenden. De flesta fåglars färgseende är tetrakromatiskt, vilket innebär att fyra typer av fotoreceptorer bidrar till deras färgseende. Det innebär att deras färgseende har en extrBirds use colour vision for many biologically relevant behaviours such as foraging and mate choice. Bird colour vision is mediated by four types of single cones, giving them an extra dimension of colour information compared to trichromatic humans. The cone photoreceptors of birds have coloured oil droplets that are assumed to increase the discriminability of colours in bright light at the cost of
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease is most likely triggered at an early age by autoantibodies primarily directed against insulin or glutamic acid decarboxylase, or both, but rarely against islet antigen-2. After the initial appearance of one of these autoantibody biomarkers, a second, third, or fourth autoantibody against either islet antigen-
Response of passerine birds to an irruption of a pine processionary moth Thaumetopoea pityocampa population with a shifted phenology The main purpose of the present work was to investigate if the passerine community was able to respond to it localized irruption of a temporally shifted population of the pine processionary moth Thaumetopoea pityocampa, the larval development of which takes place dur
INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. Both are associated with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and oxygen, resulting in ionic disturbances and eventually neuronal cell death [3]. The pathologic process t
Popular Abstract in Swedish Svår alfa-1antitrypsinbrist (AAT-brist), s.k. PiZZ, är ett ärftligt tillstånd som har en hög förekomst i Sverige, cirka 1/1600. Bristen innebär ökad risk för utveckling av kroniskt obstruktiv lungsjukdom (KOL), speciellt hos rökare. Leversjukdom är också relativt vanlig och kan förekomma såväl i barndomen som i hög ålder. Levercirros (skrumplever) och levercancer är öveSevere alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. The aims of the studies in this thesis which bases on AATD registry are to
Summary: This study is a part of the project "Lithostratigraphy and glacial dynamics during the Pomerian Phase". The objective is to solve the problems concerning the deglaciation of the south Baltic area during the last glaciation. The Polish Baltic coast is under heavy erosion from the seawaves. Steep morainic cliffs, often more than 10 meters high, offer excellent sections. A clear di
This essay tries to explain how Swedish donor organisations are working with democracy in foreign aid. Three case studies of Sida, LO-TCO Biståndsnämnd and Rädda Barnen aims to give an overview of Swedish donor organisations, their work with democracy aid, evaluation and the problems with foreign aid. With Carothers theory of democracy aiding I analyse the success of Swedish democracy promotion, h
Following Mao Zedong's new political offensive in September 1962, the Communist Youth League (CYL) was called to play a leading role in the struggle to revolutionize Chinese youth. However, as the Cultural Revolution entered its first phase, the CYL turned to be one of the most challenged institutions. Through a rigorous historical research based on archival data mainly kept in Beijing public
The Stradella system on an accordeon is a complicated construction. It has readymade con-nected chords, these are major, minor, seventh and diminished seventh. To reach other vari-ants of chords you have to combine chord/bass buttons. Which advantages and disadvantages do the use of combined chords/bass buttons mean? How is the pedagogic work affected by using the combined chords/bass buttons? I h
Summary in English The purpose of this essay has been to examine the Christology of Wolfhart Pannenberg, and especially his interpretation of the belief in Jesus as true God and true man. The consequences for his ontology and his view of the incarnation are also focused upon. Fundamental features in the Christology of Pannenberg demand a closer examination in this connection. First, christologic
The expression treaty shopping is of American origin and it is closely related to the term forum shopping, a term used in U.S. civil procedure. Forum shopping describes a behaviour by which a party in a court case tries to ''shop'' into a jurisdiction or circuit where he expects a more favourable decision to be given. When treaty shopping, one uses double taxation treaties (and/or
During the last couple of years social-workers and academics have been discussing the lack of validation and professionalism in different areas of social work. The purpose of this study was to find out what social-workers in different fields of work feel about this ongoing discussion. And also how they feel about the lack of validation in their field of work and the lack of profession status socia
Summary When tax treaties are being applied in Swedish law, they are being applied after that the taxable income has been determined according to Swedish law. Usually the tax treaties are dividing the right to tax among the parties of the treaty; this means that the taxation right for one state usually is restricted. Due to treaty abuse, the question arises, how to counter this abuse. The commen
Climate adaptation is necessary to address the impacts of the climate change which is already unavoidable due to past emissions. There is a strong need for knowledge building, for which climate-related knowledge and information needs to be made available through different types of climate services. The aim with this study is to examine how useful climate services are, as a knowledge base for decis
