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Popular Abstract in Swedish Autoimmuna sjukdomar är tillstånd där vårt immunförsvar angriper den egna kroppen. Det finns ett flertal sådana sjukdomar av vilka jag huvud-sakligen har intresserat mig för rheumatoid artrit (RA) och multipel skleros (MS). De behandlingar som finns för de drabbade är idag främst riktade mot ergonomi, smärtlindring och olika former av immunsupres-sion (tex TNFa antikropThe causes of autoimmune diseases are largely unknown today, but there is evidence supporting a substantial complex genetic influence on many of these diseases as well as environmental factors and chance. In this thesis I have tried to get one step closer to the genetic causes of two autoimmune diseases through their induced counterparts in mice, namely rheumatoid arthritis (RA) and multiple scler

Environmental problems in the energy system often originate from everyday activities and choices. Everyday activities in the home are part of the private sphere that can be contested in relation to energy policies. This article discusses the public-private divide in energy policies and how Swedish municipal energy consultants understand the divide. By analyzing the actions of energy consultants an

UNLABELLED: When microbes contaminate the macrophage cytoplasm, leukocytes undergo a proinflammatory death that is initiated by nucleotide-binding-domain-, leucine-rich-repeat-containing proteins (NLR proteins) that bind and activate caspase-1. We report that these inflammasome components also regulate autophagy, a vesicular pathway to eliminate cytosolic debris. In response to infection with flag

CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system developmen

Popular Abstract in Swedish Denna avhandling innehåller en huvudstudie och en delstudie. Syftet med huvudstudien var att följa upp en grupp ungdomar som hade blivit diagnostiserade med uppförandestörning (n=351) i det unga vuxenlivet. Delstudiens syfte var att ifrågasätta och klargöra frågeformuläret KASAM-29 och dess förhållande till den salutogena teorin. I avhandlingen användes olika utfallsvarThis dissertation consists of a primary and a secondary study. The aim of the primary study is to follow-up a group of juveniles diagnosed with conduct disorder (n=351) into adulthood. The secondary study's aim is to question, clarify and attach the questionnaire SOC-29 to the salutogenic theory.In the dissertation different outcomes and outcome measurements are fomulated and discussed. Two perspe

The group B Streptococcus, an important cause of invasive infections in the neonate, is classified into four major serotypes (Ia, Ib, II, and III) based on the structure of the polysaccharide capsule. Since the capsule is a known virulence factor, it has been extensively studied, in particular in type III strains, which cause the majority of invasive infections. Two cell surface proteins, alpha an

Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoprotei

The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'im

Surface emissions of CO2 from fossil fuel combustion (ΦFFCO2) are estimated for the Netherlands for the period of May 2006-June 2009 using ambient atmospheric observations taken at station Lutjewad in the Netherlands (6°21'E, 53°24'N, 1 m. a.s.l.). Measurements of Δ14C on 2-weekly integrations of CO2 and CO mixing ratios are combined to construct a quasi-continuous proxy record (FFCO2*) from which

This paper presents an assessment framework for methodologies under development. It is adapted from the evaluation framework for the design of an engineering model developed by Ben Ahmed and colleagues [1]. The assessment framework allows to take into account in a systematic way characteristics (that is, main categories or classes of potential requirements) that are of importance for the assessmen

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture su

Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT

Identification of cancer pathways is the central goal in the cancer gene expression data analysis. Data mining refers to the process analyzing huge data in order to find useful pattern. Data classification is the process of identifying common properties among a set of objects and grouping them into different classes. A cellular automaton is a discrete, dynamical system with simple uniformly interc

It is generally expected that, in environments with pronounced seasonal resource peaks, birds’ reproductive success will be maximised when nestlings’ peak food demand coincides with the timing of high food availability. However in certain birds that stay resident over winter, earlier breeding leads juveniles to join the winter flock earlier, which by the prior residence effect increases their succ

The impact of the transition to modern economic growth on the distribution of income is widely debated. The experience of early industrializers like Britain and the US has informed much of the debate, lending support to the idea embedded in the models of Kuznets and Lewis that real wages of laborers tend to lag behind the growth of GDP per capita in the early stages of economic development. We exa

Smokers are at higher risk of cardiopulmonary and wound-related postoperative complications than non-smokers. Our aim was to investigate the effect of preoperative smoking intervention on the frequency of postoperative complications in patients undergoing hip and knee replacement.