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A normal mineral metabolism is integral for skeletal development and preservation of bone integrity. Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating factor that decreases serum concentrations of inorganic phosphorous (P-i) and 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3]. Increased FGF-23 expression is a direct or indirect culprit in several skeletal disorders; however, the relati
The present study focuses on how patients diagnosed with psychosis deal with a conflicting situation. In the study, two groups of patients were assessed. One group consisted of patients diagnosed with psychosis (n=41), while the comparison group (n=135) consisted of inpatients diagnosed either with anorexia nervosa or with bulimia nervosa. The groups were assessed using the Serial Color Word Test
The gamma evaluation method has become the gold standard for the comparison between measured and calculated absorbed dose distributions. However, test criteria and failure rate tolerance levels have hitherto normally been based on empirical evidence, rather than rigorous statistical analysis. In this work, it is proposed that the gamma-evaluation method could be reinterpreted such that the absorbe
Background: In adults, impaired myocardial repolarization and increased risk of arrhythmia are known consequences of open heart surgery. Little is known, however, about post-operative consequences of cardiopulmonary bypass surgery in children. The aim of this study was to assess ventricular repolarization and coronary perfusion after bypass surgery for atrial septal defect (ASD) repair in children
Introduction Colon cancer is one of the most common forms of cancer world wide, with an incidence of almost 1 million cases anually. Surgery is a prerequisite for cure and the majority of patients are potentially curable at diagnosis. For a surgical resection to be curative the surgeon needs to remove the tumour together with all affected regional lymph nodes. How extensive the mesenteric resecti
This paper presents the design of a two-step process in which the first step is PEGylation of a protein, and the second step is chromatographic purification of the target mono-PEGylated protein from the unreacted and the di-PEGylated impurities. The difference between optimizing each process step separately and optimizing them simultaneously is studied. It was found that by optimizing the steps si
Montmorillonite is a key ingredient in a number of technical applications. However, little is known regarding the microstructure and the forces between silicate platelets. The size of montmorillonite platelets from different natural sources can vary significantly. This has an influence on their swelling behavior in water as well as in salt solutions, particularly when tactoid formation occurs, tha
Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous studies have shown that the reaction between small duplex RNAs (dsRNAs) and monoaquated cisplatin (cis-Pt(NH3)2Cl(OH2)(+), ) can be followed by the metal induced hyperchromicity occurring directly after addition of to e.g. microRNA mimics. In th
In this prospective study, mortality, rehabilitation, and new amputations on the same or on the contralateral leg were studied in 189 patients with diabetes who had achieved healing of an index amputation. Ninety-three patients had achieved healing after an index minor (below the ankle) and 96 after an index major (above the ankle) amputation, precipitated by a foot ulcer. The healing time was 29
Background: There are at least three broad conceptual models for the impact of the social environment on adult disease: the critical period, social mobility, and cumulative life course models. Several studies have shown an association between each of these models and mortality. However, few studies have investigated the importance of the different models within the same setting and none has been p
It has been known for nearly 30 years that the theoretical and experimental values for the energy of the 2s3s S-1 level in singly ionized boron, B it, differ strongly. Since there is much better agreement for other B II levels, it has been concluded that the experimental value for 2s3s S-1 must be revised. Despite a number of recordings over the years of sliding-spark, hollow cathode and beam-foil
The Proton Exchange Membrane (PEM) fuel cell has been investigated for a long time, and is regarded as a new energy source for various applications, such as portable, stationary and automotive ones. However, due to the shortage of the infrastructure in the society, the high cost, the difficulty of the water/thermal management, etc., practical systems have not reached the general public, yet. Of t
OBJECTIVE: To evaluate newly developed equations predicting relative glomerular filtration rate(GFR) in adult Swedish Caucasians and to compare with the Modification of Diet in Renal Disease(MDRD) and Mayo Clinic equations using enzymatic and zero-calibrated plasma creatinine assays. MATERIAL AND METHODS: GFR was measured with iohexol clearance adjusted to 1.73 m(2). One population sample (n=436/L
Popular Abstract in Swedish Den här avhandlingen handlar om hur kristaller, som innehåller en liten mängd av ämnen tillhörande gruppen sällsynta jordartsmetaller, kan användas för forskning och tillämpningar rörande kvantinformation. Genom att belysa kristallerna med laserljus kan atomernas tillstånd styras och studeras. I avhandlingen diskuteras olika aspekter av hur de sällsynta jordartsatomer sThis thesis describes investigations of the use of cryogenically cooled rare-earth-ion-doped crystals for quantum information processing and quantum optics. Several aspects of the coherent interaction between light and rare-earth ions in solids are addressed. Quantum information science has given physicists new views of quantum mechanics. The transmission of quantum states has already found pract
This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a mul
Popular Abstract in Swedish Förebyggande av hjärtkärlsjukdom har varit en utmaning för medicinsk forskning under flera decennier. Viktiga frågeställningar om såväl screeningmetodik som risk-faktor intervention söker fortfarande sitt svar och har i sig betydelse för både samhällsmedicin och klinisk verksamhet. Målsättningen för denna studie var att undersöka möjligheten för läkare och sjuksköterskoCardiovascular disease prevention has been a challenge for research for decades. The studies of this thesis were designed to investigate the role of health professionals in everyday clinical work based upon the concept of comprehensive primary care consultation. Routine check-up of blood pressure was the basis for the inclusion in an opportunistic screening for hyperchol-esterolaemia. Additionally
This article is based on a study of the sailing event America’s Cup in Malmö in the late summer of 2005. It serves the purpose of exemplifying a project of urban governance. Urban governance means that municipalities are engaged in implementing different strategies in order to strengthen their own position in the competition between cities and regions. The article’s main theme is the relation betw
