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Perceptions of diabetes control among people with type 2 diabetes treated with basal insulin in Sweden, Switzerland, and the United Kingdom

Objective: To investigate perceptions of control among people with uncontrolled and well controlled type 2 diabetes (T2D) treated with basal insulin, as well as differences in perceptions and diabetes management practices between the two groups. Research design and methods: Web surveys of 1012 people with uncontrolled T2D (HbA1c >8.0% or 64 mmol/mol) on basal insulin in Sweden, Switzerland, and th

Prevalence and intensity of pain after stroke: a population based study focusing on patients' perspectives.

OBJECTIVE: To determine prevalence and intensity of pain after stroke, focusing on patients' perspectives. METHODS: During a one year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register. After 4 and 16 months (median), 297 patients (98% of survivors) were followed up. Worst pain intensity during the previous 48 hours was assessed on a visual analo

Macro-Geometric Defects, A numerical and experimental study of springback and surface defects

Popular Abstract in Swedish Idag har kravet på kortare ledtider i bilindustrin dramatiskt ökat behovet av effektivare utvecklingsmetoder vid varje steg i processutvecklingskedjan. För att minska de långa ledtiderna för framtagning av ett formningsverktyg har man introducerat Finita Element (FE) simulering av formningsprocessen. Även om FE-simulering används inom bilindustrin idag finns fortfarandeToday, shortened lead-times in the automotive industry have dramatically increased the need for more efficient development methods at every stage of the process development chain. In order to decrease the long lead-time for producing a forming tool, sheet-metal-forming simulation was introduced. Even though sheet-metal-forming simulation is widely used in the automotive industry today, there are s

Definition of landscape erosion units using a structural classification OASIS of Landsat TM satellite imageries, case study Lebanon.

Soil erosion by water is a major cause of landscape degradation in semi-humid to semi-arid Mediterranean environments. Terrain particularly susceptible to the phenomenon witness a combination of erosive soil, unconsolidated rock type, steep slope, high rainfall intensity, active tectonic movement, rapid land use change and intense human interference. Current erosion models (e.g. USLE, RUSLE) are b

Drogval, kön och personlighet : En perceptgenetisk undersökning av narkomaner

Popular Abstract in Swedish Är narkomaners personlighet relaterad till den drog som de valt att använda och föredrar? Detta undersöktes i en grupp om 128 tunga narkotikamissbrukare varav 37 var kvinnor och 91 män. De tre droger det gällde var heroin, som användes av 30 kvinnor och 52 män, amfetamin (7 kvinnor och 32 män) och hasch (7 män). Narkomanernas personlighet bestämdes med hjälp av två perc

Enhancing students’ research and writing activities on the B- and C-levels through the use of a personal virtual learning space: examples from blended courses

Since undergraduate students often feel unprepared for and apprehensive of the research component included in the degree project (examensarbete) (Akister et al, 2006; I’Anson et al, 2004; Todd et al, 2004), we trialled the use of personal virtual learning spaces to support B- and C-level students’ research activities and enhance supervision of the writing process. The personal virtual learning s

Methodological Challenges In the Application of the Glycemic Index In Epidemiological Studies Using Data from the European Prospective Investigation into Cancer and Nutrition

Associations between the glycemic index (GI) or glycemic load (GL) and diseases are heterogeneous in epidemiological studies. Differences in assigning GI values to food items may contribute to this inconsistency. Our objective was to address methodological issues related to the use of current GI and GL values in epidemiological studies. We performed ecological comparison and correlation studies by

Benthic environmental responses to climatic changes during the late Quaternary: a micropalaeontological and geochemical approach

Popular Abstract in Swedish Genom att använda marina sedimentkärnor från havbotten kan vi dyka ner i forna tiders hav och förstå hur klimat och havsmiljö har utvecklats över tid. Sedimenten och dess innehåll av olika mikrofossil utgör ett fantastiskt miljöarkiv och ju längre ner i sedimenten vi kommer desto äldre är de vanligtvis. I mitt doktorandprojekt har jag studerat marina sediment från kusteThere is a limited understanding of how the benthic environment within upwelling regions responded to past rapid climatic changes. Within this thesis, a multiproxy approach is applied to two marine sediment cores from two coastal upwelling sites in the low latitude subtropical Atlantic. With a focus on benthic foraminiferal faunal analyses, the response of the benthic environment to rapid climatic

After Capitalism: Cyborgism

This second digital edition includes my research from 2013 until November 2015. There are many important changes from de first version. This version introduces the Technocratic Mode of Production based on the exploitation of the consumers. It includes a complete description of the cyborg society as it is today, the new castes that constitute it and the economic acts that regulate the new Mode of P

Cygnet or ugly duckling – what makes the difference? A tale of heat-pump market developments in Sweden

Who can pick a winner? Since 1974, various types of targeted support have at different times been directed at the development of the heat pump market in Sweden – which in the following decades oscillated violently between soaring sales and collapse. Eventually, however, small heat pumps for space heating of residential buildings have in recent years securely established themselves as a mature and

Manager and Civil Servant: Exploring actors' taken-for-granted assumptions in public administration

Manager och Civil Servant är en utforskning av aktörers förgivet tagna antaganden vilka styr uppfattningar kring hur offentlig förvaltning ska ske i samtida välfärdsstater. Det hävdas att mer än 30 år av pågående och riktade reformer gentemot den offentliga förvaltningen har orsakat dilemman att uppstå. Dessa dilemman har resulterat i en förskjutning av balansen kring några fundamentala pelare inoManager and Civil Servant is an exploration of actors’ taken-for-granted assumptions that govern perceptions concerning how public administration should be undertaken within contemporary welfare states. It is argued that more than 30 years of continuous reforms directed towards public administration have caused dilemmas to arise. These dilemmas have resulted in a shifting of balances regarding the

Beta-glucose 1-phosphate interconverting enzymes in Lactococcus lactis: physiological role and regulation in maltose, trehalose and glucose metabolism

Lactic acid bacteria (LAB), including Lactococcus lactis, are abundant in nature. These bacteria convert carbohydrates into mainly lactate by a rather uncomplicated metabolism. An improved understanding of the physiological and genetical mechanisms involved in carbohydrate metabolism and its regulation will improve the industrial use of LAB. The aim of this study was to investigate the maltose an

Pro- and anticoagulant mechanisms in coronary artery disease. Clinical studies on factor VII and resistance to activated protein C

Popular Abstract in Swedish Hjärtinfarkt och kärlkramp orsakas av förändringar i hjärtats kranskärl pga åderförkalkninng (ateroskleros). Fettinlagring i kärlväggen leder dels till förträngning och dels till bildning av ömtåliga plack som plötsligt kan spricka. Denna kärlväggsskada försöker kroppen reparera genom aktivering av blodets levringssystem (koagulation). Det är i denna situation inte heltThe triggering mechanism in myocardial infarction (MI) and unstable angina involves coronary thrombus formation following plaque rupture. Coagulation is initiated by tissue factor that activates factor VII (FVII), and is inhibited by protein C and its co-factor protein S. Resistance to activated protein C (APC resistance) is a common risk factor for venous thrombosis caused by a mutation in the ge

Neurogenesis and transplantation in stroke-damaged brain

Popular Abstract in Swedish Stroke hos unga vuxna råttor och möss utlöser neurogenes i den skadade regionen striatum samt i den intakta hippocampus, men eftersom stroke framförallt drabbar äldre individer, är det av största vikt att utröna åldrandets effekt på hjärnans mekanismer för återhämtning. Gamla och unga vuxna råttor inducerades med stroke genom transient ocklusion av mellersta hjärnartäreStroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. Aged and young adult rats were subjected to stroke by transient occlusion of the middle cerebral artery and proliferating cells were labeled by intraperitoneal administ

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical actiflty by glucose in wild-type and SUR1(-/-) mouse alpha-cells

Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (K-ATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50] = 2.5 mmol/l) reduction of glucagon release. Maximum inhi

Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia.

Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall

Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide.

Exercise is known to affect the airway epithelium through dehydration, followed by a release of mediators, such as club cell (Clara) protein (CC16). The aim of this study was to follow the CC16 levels at repeated time points in plasma and urine after exercise in asthmatic subjects and controls, and to relate the findings to exhaled breath temperature (EBT) and exhaled nitric oxide (NO). Twenty-two

Fixed-Parameter Algorithms for Optimal Convex Partitions and Other Results

Popular Abstract in Swedish I denna avhandling studerar jag tvådimensionella geometriska optimeringsproblem. Gemensamt för många praktiskt och teoretiskt intressanta problemställningar inom området är att det är mycket svårt att ta fram optimala lösningar. Det tar helt enkelt alltför lång tid att undersöka alla möjligheter för probleminstanser med stora mängder indata då beräkningstiden växer expoIn this thesis I study two-dimensional geometric optimization problems for which it is difficult to find efficient, exact, deterministic algorithms. All known solutions to these problems require time that is exponential in the total size of the input. The work done in this thesis is a contribution to the research directed at attacking and coping with such NP hard problems in computational geometry

Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

Popular Abstract in Swedish Parkinsons sjukdom (PS) karaktäriseras av långsam celldöd i hjärnan och gradvis uppträder minskad rörlighet och muskelstelhet som mest framträdande symptom. PS drabbar ungefär 0.1% av befolkningen, och inträder oftast i femtio- till sextioårsåldern. Varför sjukdomen uppkommer är till stor del okänt, men man vet att de dopamin producerande cellerna i mitthjärnan (särskilParkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. Importantly, the neuropathology of PD is dominated by a marked loss of dopaminergic neurons located in the substantia nigra.