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PURPOSE: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovar

BACKGROUND AND PURPOSE: The purpose of this study was to obtain a deeper understanding of the process of motivation for change in patients with prolonged musculoskeletal disorders and to identify factors that might influence change resulting in increased independence.METHOD: A qualitative two-year follow-up study. Data collection and analysis were performed according to the qualitative case study

Polarized neutron imaging brings the great advantage of analyzing bulk magnetic properties with good spatial resolution. The technique is based on the interaction of the neutron spin with magnetic samples or free magnetic fields and observing the changes to a spin-polarized neutron beam. The high sensitivity to even small magnetic fields is a benefit in obtaining magnetization information but simu

Objective: Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile (SSNP) in children with short stature or low growth velocity. Design: Using SSNP and subsequent AITT, we examined 257 children 4–18 years old (13

Over the years, electronic waste accumulation has been on a steep rise, parallel with the technological evolution of electrical and electronic equipment. Companies have adopted circular economy approach to overcome the emerging waste issue in the last few decades, where goods can return to manufacturers or remanufacturers. They can be used after certain modifications or remanufacturing processes.

Background: Women with mild breast cancer-related arm lymphedema (BCRAL) mostly receive treatment with compression garments and instructions in self-care to prevent the progression of lymphedema. However, wearing a compression garment may be experienced as negative and may affect health-related quality of life (HRQOL) more than the lymphedema itself. The aim of this study was to investigate if the

The hippocampus is one of the most challenging brain regions for proton MR spectroscopy (MRS) applications. Moreover, quantification of J-coupled species such as myo-inositol (m-Ins) and glutamate + glutamine (Glx) is affected by the presence of macromolecular background. While long echo time (TE) MRS eliminates the macromolecules, it also decreases the m-Ins and Glx signal and, as a result, these

Background: Anterior resection (AR) is considered the gold standard for curative cancer treatment in the middle and upper rectum. The goal of the sphincter-preserving procedure, such as AR, is vulnerable to anastomotic leak (AL) complications. Defunctioning stoma (DS) became the protective measure against AL. Often a defunctioning loop-ileostomy is used, which is associated with substantial morbid

The purpose of this study was to use an electromyography (EMG) based muscle model to investigate the performance enhancement of stretch-shortening cycle (SSC) tasks at different elbow flexion-extension velocities. A torque motor was used to oscillate the forearms of seven healthy male subjects (23-40 years) during SSC and non-SSC contractions at four frequencies of movement (.58, 1.5, 2.4 and 3.3

Background: Due to the COVID-19 pandemic, physical visits were replaced by video visits. The aim of this study was to evaluatethe rapid implementation of telehealth video visits in cancer care from the perspectives of patients and healthcare professionals togain knowledge about when physical visits can be replaced by video visits and to identify the improvements needed to optimizecancer care.Mater

Austerity appears to be a globally coordinated restructuring process, where international and national governments cooperate to stymie economic crisis and socialize the costs of systemic economic failure. However, austerity is also shaped from the bottomup. This paper examines the 2008 bankruptcy of Vallejo, California. This city of under 120 000 people became the first municipal bankruptcy in the

Biological aerosol particles affect human health, are essential for microbial and gene dispersal, and have been proposed as important agents for atmospheric processes. However, the abundance and size distributions of atmospheric biological particles are largely unknown. In this study we used a laser-induced fluorescence instrument to measure fluorescent biological aerosol particle (FBAP) concentra

Background: Despite newer treatments with immunosuppressive agents, there still exists a considerable morbidity and mortality risk among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Since 1994 the European Vasculitis Society (EUVAS) has aimed for an improved outcome for patients with AAV, conducting several prospective randomized controlled trials (RCTs).

An Escherichia coli expression system was constructed for production of a recombinant antimicrobial peptide buforin derivative named buforin IIb and a large-scale process of cultivation and purification was also developed. Inclusion bodies of fusion proteins containing recombinant buforin IIb were released from high-density-cultured cells by high-pressure homogenization. The inclusion bodies

Cell type deconvolution - the computational estimation of cellular composition in bulk tissue samples - is a valuable tool in cancer research for understanding immune infiltration and tissue heterogeneity. Most deconvolution algorithms infer the composition of cell types in bulk samples by modeling the observed expression data as a linear combination of reference expression profiles from each cell

The extensive use of neonicotinoids has raised concerns about their impact on pollinators like hoverflies, which are vital for pollination and ecosystem health. This study develops and validates a green extraction method using Supercritical Fluid Extraction (SFE), coupled with HPLC (High Performance Liquid Chromatography) - MS/MS (Mass Spectrometry) for selective analysis. SFE was employed as a m

Background: There has recently been an increased emphasis on patient empowerment and collaboration within their healthcare. However, there is widely a lack of clarity to the concept of empowerment and existing measurement tools lack uniformity, covering diverse domains and related concepts. Objectives: This study aims to conduct a psychometric evaluation of the Swedish version of the Empowerment S