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Mathematical Modeling of Brain Circuitry during Cerebellar Movement Control

Reconstruction of movement control properties of the brain could result in many potential advantages for application in robotics. However, a hampering factor so far has been the lack of knowledge of the structure and function of brain circuitry in vivo during movement control. Much more detailed information has recently become available for the area of the cerebellum that controls arm–hand movemen

Experimental Neuroretinal Transplantation

Embryonic full-thickness rabbit neuroretinal sheets were transplanted to the subretinal space of adult hosts. This was accomplished by using a new transplantation technique involving vitrectomy and retinotomy. The grafts were followed from 10 to 306 days after surgery, and were then examined by different histological techniques. In the light microscope, the transplants were seen to develop the nor

Learning to evaluate conditional partial plans

We study agents situated in partially observable environments, who do not have sufficient resources to create conformant plans. Instead, they generate plans which are conditional and partial, execute or simulate them, and learn to evaluate their quality from experience. Our agent employs an incomplete symbolic deduction system based on active logic and situation calculus for reasoning about action

Lost in Transitions: Sustainability Strategies and Social Contexts

Popular Abstract in Swedish Företag efterfrågas alltmer att tillhandahålla innovativa lösningar som adresserar miljöproblem och sociala aspekter, såsom ihållande fattigdom, miljöförstöring och klimatförändringar. Paradoxen i denna efterfråga är att under den gällande ekonomiska logiken, kommer de flesta företag finna arbetet på dessa gränssnitt problematiskt. Någon form av spänning är oundvikligt Corporations are increasingly asked to provide innovative solutions to address environmental and social concerns, such as persistent poverty, pollution and climate change. The paradox in this call is that within the current economic logic, most companies will continue to find working at these interfaces problematic. Some sort of tension is inevitable because of the conflicting and competing demand

Evaluation of lumbar spine images with added pathology

Optimisation of radiographic procedures require solid tools for evaluation of the image quality in order to ensure that it is sufficient to answer the clinical question at the lowest possible absorbed dose to the patient. Lumbar spine radiography is an examination giving a relatively high dose and good methods for evaluation of image quality as well as dose are needed. We have developed and used a

Characterization of radioactive particles using non-destructive alpha spectrometry.

Spherical particles with known properties were used to demonstrate and test a novel software package known as AASIFIT, which is able to unfold complex alpha spectra. A unique feature of the program is that it uses simulated peak shapes in the fitting process. The experimental reference particles in the testing were artificially produced U particles of diameter 1.4mum and a nuclear bomb particle wi

Alignment Practices Affect Distances in Software Development: A Theory and a Model

Coordinating a software project across distances is challenging. Even without geographical and time zone distances, other distances within a project can cause communication gaps. For example, organisational and cognitive distances between product owners and development-near roles such as developers and testers can lead to weak alignment of the software and the business requirements. Applying good

Numerical modelling of nearshore waves, currents, and sediment transport: Validation with laboratory data

A numerical model of nearshore waves, currents and sediment transport was developed. The wave conditions were calculated by the Modified-EBED model and the surface roller was modeled following the approach of Daily and Brown (1995) with an enhancement of the energy flux term in the alongshore direction. Nearshore currents and wave setup were determined by the depth-averaged momentum equations toge

Interfacial behaviour of surfactants and enzymes: studies at model surfaces

Popular Abstract in Swedish Denna avhandling presenterar resultat från experimentella studier av tensiders och enzymers beteenden vid modellytor. Ellipsometri var den i huvudsak använda tekniken i dessa undersökningar. Studier av tensidadsorption i statiska och dynamiska vätningssituationer initierades för att undersöka adsorptionsbeteenden i närheten av trefaslinjen under dynamisk vätning. I fal

Long-term psychological effects of carrier testing and prenatal diagnosis of haemophilia: Comparison with a control group

The long-term psychological effects resulting from carrier testing and prenatal diagnosis (PD) of haemophilia were evaluated by comparing mental symptomatology scores (Symptom Check List, SCL-90) for 50 carriers of haemophilia who had undergone PD about five years earlier, 55 carriers who had not undergone PD and 262 control women who were not carriers. All of the women had children. Carrier testi

Electron impact excitation for He-like ions with Z = 20-42

Aims. Spectral lines of He-like ions are among the most prominent features in X-ray spectra from a large variety of astrophysical and high-temperature fusion plasmas. A reliable plasma modeling and interpretation of the spectra require a large amount of accurate atomic data related to various physical processes. In this paper, we focus on the electron-impact excitation (EIE) process. Methods. We a

Full-thickness retinal transplants : a review

Embryonic full-thickness rabbit neuroretinal sheets were transplanted to the subretinal space of adult hosts. This was accomplished by using a new transplantation technique involving vitrectomy and retinotomy. The grafts were followed from 10 to 306 days after surgery and were then examined by different histological techniques. In the light microscope, the transplants were seen to develop the norm

Industrialized Building Companies' Business Models : Multiple Case Study of Swedish and North American Companies

Industrialized building companies apply various product predefinition strategies, derived from market- or resource-based strategic perspectives. This strongly affects the buildup of such companies' business models and their operational structure. Ten companies were included in a case study, presenting strategic orientations and business models. The aim of this study was to analyze the primary char

The structural basis for complement inhibition by gigastasin, a protease inhibitor from the giant Amazon leech

Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat

Distribution and variation of indoor temperatures in apartment blocks with individual metering and billing of space heating costs—on building, apartment, and room level

A good indoor thermal climate is important. To reduce energy demands for space heating, individual metering and billing (IMB) for space heating costs is common, though not yet in Sweden. To obtain a better picture of the thermal climate conditions, the distribution of the measured indoor temperatures was investigated in each apartment in 14 apartment blocks with a total of 419 apartments. All bloc

The temperature dependence of the laminar burning velocity of ethanol flames

The Heat Flux method was extended for the first time towards liquid fuels and used to determine burning velocities under conditions when the net heat loss from the flame to the burner is zero. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. Uncertainties of the measurements were analyzed and assessed experimentally. The overall accuracy of the burning velocities was est

Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth

In the present paper, we have studied particle dissolution and crystal growth of the poorly water soluble drug felodipine, using fluorescence as a probe for the amount of crystalline material. Dissolution kinetics is essentially diffusion-controlled, while the rate of crystal growth is significantly slower compared to the diffusion-controlled limit. The deviation from diffusion control was charact

Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors

Rat dopamine D(2short) expressed in Chinese hamster ovary (CHO) cells were characterized by means of activation of [(35)S]-guanosine 5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS) binding and inhibition of [(3)H]raclopride binding. Among 18 dopaminergic ligands studied dopamine, NPA, apomorphine and quinpirole were full agonists in activation of [(35)S]GTPgammaS binding, while seven ligands were