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Quantification of the absorption and scattering effects of diffusers in a room with absorbent ceiling

In ordinary public rooms, such as classrooms and offices, an absorbent ceiling is the typical first acoustic action. This treatment provides a good acoustic baseline. However, an improvement of specific room acoustic parameters, operating for specific frequencies, can be needed. It has been seen that diffusing elements can be effective additional treatment. In order to choose the right design, pla

Modeling symbiotic biological nitrogen fixation in grain legumes globally with LPJ-GUESS (v4.0, r10285)

Biological nitrogen fixation (BNF) from grain legumes is of significant importance in global agricultural ecosystems. Crops with BNF capability are expected to support the need to increase food production while reducing nitrogen (N) fertilizer input for agricultural sustainability, but quantification of N fixing rates and BNF crop yields remains inadequate on a global scale. Here we incorporate tw

Reconstitution of Membrane-Bound Enzymes for Neutron Scattering Studies: A Case Study of Human Dihydroorotate Dehydrogenase

Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. The aim of this doctoral thesis was to investigate the mechanism of action and inhibition of membrane-bound enzymes that interact with lipids and lipophilic su

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer’s Disease

Background: Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. Objectives: We evaluated the efficacy and safety of aducanumab in early Alzheimer’s disease. Design: EMERGE and ENGAG

Hur skapas en rebelltjej på svenska? : Om översättningen av Elena Favillis och Francesca Cavallos Good Night Stories for Rebel Girls

This article investigates the translation of Good Night Storiesfor Rebel Girls: 100 Tales of Extraordinary Women, a children’s bookwritten and published by Elena Favilli and Francesca Cavallo in 2016.Within the framework of Gideon Toury’s Descriptive Translation Studiesand Katharina Reiss’ text typology, the study focuses on the Swedish trans-lation Godnattsagor för rebelltjejer: 100 berättelser o

Enhancing teachers’ classroom communication skills – Measuring the effect of a continued professional development programme for mainstream school teachers

Continued professional development (CPD), tailored to teachers’ needs and expectations, is required for updated skills and knowledge. In this study, twenty-five teachers working with first and second grade students participated in an 11-week programme focusing on enhancing classroom communication. The participating teachers were randomly assigned to either a direct intervention track (intervention

A Holocene relative sea-level database for the Baltic Sea

We present a compilation and analysis of 1099 Holocene relative shore-level (RSL) indicators located around the Baltic Sea including 867 relative sea-level data points and 232 data points from the Ancylus Lake and the following transitional phase. The spatial distribution covers the Baltic Sea and near-coastalareas fairly well, but some gaps remain mainly in Sweden. RSL data follow the standardize

PD-L1 Testing in Cytological Non-Small Cell Lung Cancer Specimens : A Comparison with Biopsies and Review of the Literature

INTRODUCTION: Programmed death-ligand 1 (PD-L1) expression is used for treatment prediction in non-small cell lung cancer (NSCLC). While cytology may be the only available material in the routine clinical setting, testing in clinical trials has mainly been based on biopsies.METHODS: We included 2 retrospective cohorts of paired, concurrently sampled, cytological specimens and biopsies. Also, the l

Assessing the potential and hydrological usefulness of the CHIRPS precipitation dataset over a complex topography in Pakistan

This study evaluates the spatial and temporal performance of the Climate Hazard Group InfraRed Precipitation Satellite (CHIRPS) against Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) 3B42/3B43 v. 7 and Global Precipitation Measurement (GPM)-based Integrated Multi-Satellite Retrievals for GPM (IMERG V06), from 2000 to 2013. Several statistical metrics were

Private ICT-Activities and Emotions at Work : A Swedish Diary Study

The boundaries between the work and non-work spheres have been challenged through the rapid development of information and communication technology (ICT). Individuals may easily engage in non-work (family and private) matters at work and during working hours. Prior research on emotions at work tends to understand all emotions at work as work related. By studying non-work matters managed through IC

Data integration and visualization in type 2 diabetes research and care: From biological mechanisms to precision medicine.

Background. Type 2 diabetes (T2D) is a complex heterogeneous disorder affecting multiple organs. Gene expression studies in organs central to T2D, such as pancreatic islets and skeletal muscle will help elucidate and disentangle molecular mechanisms underlying T2D. Deep phenotyping using commonly measured clinical variables allows for the identification of clinically relevant T2D subgroups, repres

Matching experimental and three dimensional numerical models for structural vibration problems with uncertainties

The simulation model which examines the dynamic behavior of real structures needs to address the impact of uncertainty in both geometry and material parameters. This article investigates three-dimensional finite element models for structural dynamics problems with respect to both model and parameter uncertainties. The parameter uncertainties are determined via laboratory measurements on several be

Spectral induced polarization: frequency domain versus time domain laboratory data

Spectral information obtained from induced polarization (IP) measurements can be used in a variety of applications and is often gathered in frequency domain (FD) at the laboratory scale. In contrast, field IP measurements are mostly done in time domain (TD). Theoretically, the spectral content from both domains should be similar. In practice, they are often different, mainly due to instrumental res

Substantial clinical benefit and patient acceptable symptom states of the Forgotten Joint Score 12 after primary knee arthroplasty

Background and purpose - Knowing how to interpret values obtained with patient reported outcome measures (PROMs) is essential. We estimated the substantial clinical benefit (SCB) and patient acceptable symptom state (PASS) for Forgotten Joint Score 12 (FJS) and explored differences depending on methods used for the estimates. Patients and methods - The study was based on 195 knee arthroplasties (K

A Computer Program for Assessing Histoanatomical Morphometrics in Ultra-High-Frequency Ultrasound Images of the Bowel Wall in Children : Development and Inter-Observer Variability

Ultra-high-frequency ultrasound (UHFUS) has a reported potential to differentiate between aganglionic and ganglionic bowel wall, referred to as histoanatomical differences. A good correlation between histoanatomy and UHFUS of the bowel wall has been proven. In order to perform more precise and objective histoanatomical morphometrics, the main research objective of this study was to develop a compu

RCS-Based 3D Millimeter-Wave Channel Modeling Using Quasi-Deterministic Ray Tracing

This paper introduces a low-complexity ultra-wideband quasi-deterministic ray tracing (QD-RT) method for statistical analysis of wireless channels. This model uses a statistical distribution to model the bistatic radar-cross-section (RCS) of irregular objects such as cars and pedestrians, instead of a deterministic propagation model, i.e., applying the exact values of bistatic RCSs. It is shown th

Lessons from the 'Dark' Side: Emotional Labour and Positioning in Cross-Sectoral Collaborations

Collaboration across disciplines and stakeholders is important in handling complex societal problems. Even if collaborating is acknowledged as contributing towards societal change and innovation, collaborators’ emotional experiences during development, consolidation and completion of a given project are underexplored. This article discusses emotional labour in three cross-sectoral collaborations u

Markers of imminent myocardial infarction

Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction