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Popular Abstract in Swedish Förmaksflimmer är den vanligaste rytmrubbningen i hjärtat som kräver behandling. Risken att drabbas ökar med åldern och 8% av alla åttioåringar lider av förmaksflimmer. Förmaksflimmer är i sig inte livshotande, men den förhöjda risken för proppbildning i förmaken kan leda till allvarliga komplikationer såsom stroke. Det finns olika behandlingsstrategier för förmaksflimmThis thesis deals with signal processing algorithms for analysis of the electrocardiogram (ECG) during atrial fibrillation (AF). Such analysis can be used for diagnosing patients, and for monitoring and predicting their response to various treatment. The thesis comprises an introduction and five papers describing methods for ECG-based modeling and characterization of AF. Paper I--IV deal with meth

Gene and protein expression is controlled so that cells can react to changing intra- and extracellular signals by modulating biochemical networks and pathways. We have previously shown that gene expression and the properties of expressed proteins are dynamically correlated. Here we investigated correlations between gene related parameters and gene expression patterns, and found statistically signi

Popular Abstract in Swedish Avhandlingen innehåller fyra artiklar som berör olika aspekter av offentlig omfördelning i välfärdsstaten. Avhandlingen syftar till att ge kunskap om konsekvenser av, motiv för och mätande av och denna omfördelning. Den första artikeln ställer frågan: Hög hög skatteomfördelning från arbetande till icke arbetande kan motiveras av grundantagandet att naturresurser är gemThis thesis is an attempt to generate knowledge about the justification, measurement and consequences of public redistribution. The first paper poses the following question: How much redistribution from working to non-working can be justified by arguing that external resources are owned jointly by all, or that ownership should ideally be divided equally? This question is analyzed using bargaining

An educational method that is becoming all the more common at colleges and universities is that of the seminar. In the seminar, students write academic papers and reports, present them, and act as opponents on each other’s work. The book covers all the sections that are normally included in the seminar. The learning environment of the seminar is based on a scientific way of thinking and on scienti

In an organization where the safety level is high and incidents and serious accidents are very rare, a steady erosion of safety awareness and protective measures can occur, especially when productive demands rise. Thus, it is important to continuously identify and monitor aspects in the organization that can affect work performance and safety. In an ongoing joint research project between the LFV G

This paper deals with optimal load balancing in telecommunication networks. For a capacitated telecommunications network with single path routing and an estimated traffic demand matrix, we wish to determine the routing paths aiming at min-max optimization of link loads. To solve this problem, we propose a column (path) generation based heuristic. In the first step, we use column generation to solv

Atmospheric aerosol particles are involved in several important processes including the formation of clouds and precipitation. A considerable fraction of the ambient aerosol mass consists of organic compounds of both primary and secondary origin. These organic compounds are often semi-volatile and susceptible to oxidation which makes the organic aerosol a dynamic system, both chemically and physic

Popular Abstract in Swedish Är ledgångsreumatism en immunreaktion mot brosk? Kroppens immunförsvar bygger på ett antal olika vita blodkroppar, immunceller, som cirkulerar i blod och lymfa på spaning efter främmande och farliga "angrepp". Immuncellerna sägs svara på "angrepp", sådana immunsvar dirigeras av s k T-hjälparceller (Th-celler). Th-cellerna kommer från benmärgen, men de blir inte funktioThis thesis is based on work trying to understand the normal and pathological interactions taking place between the immune system and cartilage, specifically involving the cartilage-specific protein typ II collagen (CII). The work has been carried out in an experimental model of rheumatoid arthritis namely collagen type II induced arthritis (CIA) in mice. CIA can be triggered in mice of certain MH

Introduction of roughness by ribs in flow passages is a popular method of enhancing heat transfer in the cooling passages, e.g., of turbine blades and combustors. It is essential to accurately predict the enhancement of heat transfer generated by the ribs to ensure good design decisions. In most of the studies square ribs have been considered, but in practice such ribs may appear rounded due to im

Recent evidence challenges the widely held view that the hippocampus is specialized for episodic memory, by demonstrating that it also underpins the integration of information across experiences. Contemporary computational theories propose that these two contrasting functions can be accomplished by big-loop recurrence, whereby the output of the system is recirculated back into the hippocampus. We

In clinical transplantation today, the donor heart is preserved with cold ischemic storage that gives safe preservation for 4 hours. Non-ischemic perfusion preservation is able to preserve the donor heart for 24 hours in pre-clinical studies. The aim of this thesis is to investigate: 1. how potassium, magnesium, and temperature affect the coronary artery contractility; 2. how much oxygen a cardiop

The use of total lipid phosphate as a measure of biomass was evaluated in soils with different organic matter content. Lipids were extracted with a one-phase mixture of chloroform, methanol, and a buffer, and digested with either persulfate or perchloric acid to liberate lipid-bound phosphate. This procedure was evaluated by varying the extraction buffer, the extraction and digestion times, the am

In order to calculate building energy usage, apart from the technical characteristics, user related factors needs to be determined. Unless the user related factors are determined by specific project, the idea is to apply a standardized list of input data for a normal operation during a normal year, so the calculated energy value does not depend on variation of these factors. Such list was issued b

The non-equilibrium dynamics of electrons and nuclei govern the function of photoactive materials. Disentangling these dynamics remains a critical goal for understanding photoactive materials. Here we investigate the photoinduced dynamics of the [Fe(bmip)2]2+ photosensitizer, where bmip = 2,6-bis(3-methyl-imidazole-1-ylidine)-pyridine, with simultaneous femtosecond-resolution Fe Kα and Kβ X-ray em

In beer, the main amphiphilic components are protein and iso-humulone. Two major populations of protein are identified as lipid transfer protein (LTP) (9.7 kDa) and protein Z (43 kDa). In this paper, protein and iso-humulone are extracted from barley malt and hop, respectively, based on the brewing process. Mixtures of protein and iso-humulone are mixed at different concentrations and centrifuged.

Quantitative proteomics plays an important role in validation of breast-cancer-related biomarkers. In this study, we systematically compared the performance of label-free quantification (LFQ) and SILAC with shotgun and directed methods for quantifying breast-cancer-related markers in microdissected tissues. We show that LFQ leads to slightly higher coefficient of variation (CV) for protein quantif

Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain-hindbrain malformation known as the 'molar tooth sign'. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is al

In this thesis fabrication and optimization of vertical III-V Tunneling Field-Effect transistors was explored. Usage of vertical nanowires, allows for combination of materials with large lattice mismatch in the same nanowire structure. TFETs in this thesis were fabricated using vertical InAs/GaSb or InAs/InGaAsSb/GaSb nanowires of high material quality. Usage of these material systems allowed for