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Apolipoprotein A-I (ApoA-I) is the major protein constituent of high-density lipoprotein particles, and as such is involved in cholesterol transport and activation of LCAT (the lecithin:cholesterol acyltransferase). It may also form amyloidal deposits in the body, showing the multifaceted interactions of ApoA-I. In order to facilitate the study of ApoA-I in various systems, we have developed a pro
Reliable prediction tools are yet to be developed for estimating the accurate acoustic performance of lightweight structures, which are vital especially in the design process. This paper presents a sound insulation prediction model based on artificial Neural Networks (NN) to estimate acoustic performance for airborne and impact sound insulation of floor structures. At an initial stage, the predict
Agri-environment schemes are programmes where landholders enter into voluntary agreements (typically with governments) to manage agricultural land for environmental protection and nature conservation objectives. Previous work at local scale has shown that these features can provide additional floral and nesting resources to support wild pollinators, which may indirectly increase floral visitation
Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytok
Involving professionals in research can ensure the acquisition of knowledge, that is relevant, applicable and sustainable. Professionals are people who work in health systems, or organisations that contribute to health systems, such as practitioners, managers or other decision-makers. They have context-specific knowledge which the researchers often lack. Therefore, when they are involved in resear
Context. Multiplanet systems are excellent laboratories to test planet formation models as all planets are formed under the same initial conditions. In this context, systems transiting bright stars can play a key role, since planetary masses, radii, and bulk densities can be measured. Aims. GJ 9827 (K2-135) has recently been found to host a tightly packed system consisting of three transiting smal
We present an interactive online workshop for K-12 students, which aims in familiarizing students with core concepts of AI. The workshop consists of a variety of resources, inspired by inquiry-based learning techniques, of which we present in detail one module, centered around a browser-based game called “Gradient Descent”. This module introduces the mathematical concepts behind a gradient descent
We report on experimental detection of the spin-orbit interaction field in an InAs nanowire double quantum dot device. In the spin blockade regime, leakage current through the double quantum dot is measured and is used to extract the effects of spin-orbit interaction and hyperfine interaction on spin state mixing. At finite magnetic fields, the leakage current arising from the hyperfine interactio
Recently, Peritoneal Surface Oncology Group International (PSOGI) developed a novel comprehensive treatment consisting of cytoreductive surgery (CRS) and perioperative chemotherapy (POC) for the treatment of peritoneal metastases (PM) from gastric cancer with curative intent. This article reviews the results of this treatment and verifies its indication. In this strategy, peritoneal cancer index (
Incumbent firms face growing pressure to transform their business towards sustainability. However, business models for sustainability (BMfS) and circularity are grounded in fundamentally different institutional logic which, for incumbents, creates tensions with existing business models, structures and routines. How organizations manage tensions from conflicting logics is explored comprehensively i
Heat exchanger network synthesis (HENS) is an effective tool for heat recovery in chemical and petrochemical industries. This study aims to show a method for HENS with the consideration of different shell-side flow arrangements in shell-and-tube heat exchangers. The proposed MINLP model is modified from the stage-wise superstructure model, incorporating newly developed correlations for shell-side
In boreal summer, circumglobal Rossby waves can promote stagnating weather systems that favor extreme events like heat waves or droughts. Recent work showed that amplified Rossby wavenumber 5 and 7 show phase-locking behavior which can trigger simultaneous warm anomalies in different breadbasket regions in the Northern Hemisphere. These types of wave patterns thus pose a potential threat to human
In all times, societies have known social hierarchies and boundaries between individuals and groups with distinct social characteristics. The extent to which such hierarchies and boundaries are consequential for life outcomes and persist over time differs between societies. These changes over generations in the social structure, and the social, economical, and institutional developments that shape
Background: Although many people infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) experience no or mild symptoms, some individuals can develop severe illness and may die, particularly older people and those with underlying medical problems. Providing evidence-based interventions to prevent SARS-CoV-2 infection has become more urgent with the potential psychological toll i
When Iran directed over 300 missiles and drones at Israel on April 13, Jordan helped fend off the attack. Initial media reports suggested that several other Arab states assisted in Israel’s defense, efforts they later denied. Nonetheless, a chorus of Israeli leaders, as well as some observers in Washington, interpreted these acts as a sign of a major shift. These Arab states, the argument went, wo
The novel Coronavirus disease 2019 (COVID-19) presents a major threat to public health but can be prevented by safe and effective COVID-19 vaccines. Vaccine acceptance among healthcare workers (HCWs) is essential to promote uptake. This study, aimed to determine the COVID-19 vaccination uptake and hesitancy and its associated factors among HCWs in Tanzania. We employed a convergent-parallel mixed-
With the onset of climate change, adaptive action must occur at all scales, including locally, placing increasing responsibility on the public. Effective communication strategies are essential, and adaptation games have shown potential in fostering social learning and bridging the knowledge-action gap. However, few research efforts so far give voice to participants that engage with collaborative g
This study presents the analysis of Upper Triassic sediments from five locations in North Dobrogea (Romania) and the Black Sea. Microfacies analyses on thin sections from the Frecăţei log reveal a shallowing trend and likely an increase in energy upward into the section. The oldest part of the log is characterised by deposition of mudstones transitioning to wackestones, wit
Virtual Reality (VR) as a complementary tool for medical practitioners in the assessment and rehabilitation of people who have suffered a traumatic brain injury (TBI) is discussed. A pilot-study has been undertaken on a prototype VR assessment tool. The design involved nine occupational therapists with expertise in the care of traumatic brain injured patients and one (computer experienced) patient
The hyperfine coupling constants and the natural radiative lifetimes of the 5 p 2 P 3/2 and 6 p 2 P 3/2 levels of K 39 were determined in a level crossing experiment on an enriched K 39 sample in a sealed-off resonance cell. The following results were obtained: ----- -- a (5 p 2 P 3/2 ) = 1.973 (12) MHz -- a (6 p 2 P 3/2 ) = 0.886 (8) MHz ----- -- b (5 p 2 P 3/2 ) = 0.870 (18) MHz -- b (6 p 2 P 3/
