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Background: Increasing evidence suggests that total metabolic tumor volume (tMTV) measured before treatment in lymphoma patients undergoing [18F]fluorodeoxyglucose (FDG) PET/CT scans can predict prognosis. However, there is a lack of fast, reliable, and easy-to-perform multilesional segmentation tools with an urgent need to improve tMTV segmentation workflow in clinical practice. Here, we develop
The main purpose of this Master´s thesis, is to describe and discuss what constitutes the library collaboration between The Swedish Royal Library and the National Library of Guatemala, but also to analyse which effects the support has for public library work in Guatemala. The data consists of interviews and direct-observations during 2 months of fieldwork in Guatemala, Central America. The analysi
Purpose: Digital anthropomorphic breast phantoms have emerged in the past decade because of recent advances in 3D breast x-ray imaging techniques. Computer phantoms in the literature have incorporated power-law noise to represent glandular tissue and branching structures to represent linear components such as ducts. When power-law noise is added to those phantoms in one piece, the simulated fibrog
Socioeconomic development initiatives (SDIs) have become a controversial issue. In giving skill trainings and credit supports, practitioners assume that SDI participation will enhance women’s income/dignity. Some studies have indicated that SDIs reduce women’s exposure to marital violence (MV), while others have shown that they increase spousal conflicts/MV. Our study explains how SDI participatio
In this paper we present a framework for solving two-phase flow problems in porous media. The discretization is based on a Discontinuous Galerkin method and includes local grid adaptivity and local choice of polynomial degree. The method is implemented using the new Python frontend Dune-FemPy to the open source framework Dune. The code used for the simulations is made available as Jupyter notebook
MicroRNAs are small non-coding RNAs, which negatively regulate the expression of target genes. They have emerged as important modulators in beta cell compensation upon increased metabolic demand, failure of which leads to reduced insulin secretion and type 2 diabetes. To elucidate the function of miRNAs in beta cells, insulin-secreting cell lines, such as the rat insulinoma INS-1 832/13 and the hu
High-risk (HR) human papillomavirus (HPV) infection is an established cause of malignant disease. We used a societal perspective to estimate the cost of HR HPV-related cervical, vulvar, vaginal, anal, and penile precancer and cancer, and oropharyngeal cancer in Sweden in 2006, 1 year before HPV vaccination became available in the country. Materials and methods This prevalence-based cost-of-illness
Svensk sammanfattningAvhandlingens syfte har varit att studera utvecklingen av en könskromosom i realtid genom att simulera dess framväxt i en hermafroditisk plattmask i laboratoriet. Jag gjorde detta genom att selektera på dels honlig fitness (fitness via ägg), dels hanlig fitness (fitness via spermier) med hjälp av en genetisk markör, som agerade som en könsbestämmande gen. Detta ska efterlikna Sex chromosome evolution in a hermaphrodite ancestor starts with the establishment of a sex-determining region (SDR). Over time, sex-specific genes, and/or sexually antagonistic alleles will become linked to the SDR. Sexually antagonistic alleles are a type of genetic variation that increases fitness for one sex while being detrimental for the other sex. Recombination arrest around the SDR and gen
Gaussian models are frequently used for road elevations. However, these models are often only valid for short sections of the road. Here we present a comprehensive approach to describe various aspects of road surface/elevation by using extensions of Gaussian models arising from random gamma distributed variances. These random variances result in the Laplace distribution and thus we refer to the so
Scallops possess a visual system comprising up to 200 eyes, each containing a concave mirror rather than a lens to focus light. The hierarchical organization of the multilayered mirror is controlled for image formation, from the component guanine crystals at the nanoscale to the complex three-dimensional morphology at the millimeter level. The layered structure of the mirror is tuned to reflect th
Central limit theorems for linear statistics of lattice random fields (including spin models) are usually proven under suitable mixing conditions or quasi-associativity. Many interesting examples of spin models do not satisfy mixing conditions, and on the other hand, it does not seem easy to show central limit theorem for local statistics via quasi-associativity. In this work, we prove general cen
The coadsorption of hydrogen with a simple chiral modifier, alanine, on Ni{111} was studied using density functional theory in combination with ambient-pressure X-ray photoelectron spectroscopy and X-ray absorption spectroscopy at temperatures of 300 K and above, which are representative of chiral hydrogenation reactions. Depending on the hydrogen pressure, the surface enables protons to "pop-on a
Background: Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, with the majority of data from single-centre series. This study analysed data from an international collaboration to determine robust parameters that could inform clinical decision-making. Methods: Anonymized data on patients who had pelvic exenteration for LRRC between 2004 and 2014 we
More than 20 million Americans are affiliated with Multi-Level Marketing firms (MLMs), but there is little empirical evidence on who participates in this controversial part of today's labor market. We link data on 350,000 individuals cited in an FTC settlement with one of the largest MLMs to detailed county-level information. We find that participation is greater in areas with higher median income
As an effective strategy to control the combustion of advanced combustion modes, the application of variable valve timing (VVT) in reactivity controlled compression ignition (RCCI) combustion was investigated in this study. By coupling KIVA-3V code with genetic algorithm, the combustion of a heavy-duty engine with RCCI combustion combined with VVT strategy was optimized under a wide load range. At
What does ‘sexual citizenship’ mean in practice for people with mobility impairments who may need professional support to engage in sexual activity? The book explores this subject through empirical investigation based on case studies conducted in four countries – Sweden, England, Australia and the Netherlands – and develops the abstract notion of ‘sexual citizenship’ to make it practically relevan
Aim: The aim of this study was to investigate language ability in internationally adopted children aged 7-8 years with and without a unilateral cleft lip and palate. Methods: We compared 27 internationally adopted children with a unilateral cleft lip and palate, adopted from China, with a group of 29 children without a cleft lip and palate, adopted from different countries. Participants were recru
