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Telomeres in ecology and evolution: Hypotheses and connections between telomere length, infections and life history trade-offs

Studying life history strategies is crucial for understanding the diversity among organisms. The trade-offs in traits related to survival, self-maintenance and reproduction play an important role in the variation of life histories and can be adjusted in response to environmental and physiological factors. Telomeres, which are repetitive DNA sequences found at the ends of chromosomes, can serve as

Electron Transport in Quantum Dots Defined in Low-Dimensional Semiconductor Structures

Popular Abstract in Swedish I denna avhandling studeras ledningsförmågan hos nanometer-stora kvantprickar tillverkade i halvledarmaterial. Halvledare är material vars ledningsförmåga ligger någonstans mellan ledare (metaller) och isolatorer. I halvledare kan ledningsförmågan ändras med elektriska fält, vilket har möjliggjort utvecklandet av halvledartransistorn. Utvecklandet av halvledartransistorThis thesis focuses on electron transport in single and double quantum dots defined in low-dimensional, narrow-band-gap III-V semiconductor materials. Fabrication schemes are presented for defining single and double quantum dots in lateral InGaAs/InP heterostructures, either by a combination of etching and local gating or solely by local top gating. The quantum dots are here electrostatically conf

Exploring salutogenic design of assistive products from unpleasant feelings expressed by users in two studies

Assistive products may elicit unpleasant feelings within both the actual user and persons around. By analysing two complementary studies, this paper tries to illuminate which unpleasant feelings may be elicited. In study A industrial design students evaluated assistive products. In study B young persons with disabilities were interviewed about their everyday experiences. Negative statements by par

Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer

The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and dir

Not all those who wander are lost : A study of cancer cells by digital holographic imaging, fluorescence and a combination thereof

Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when

Clonidine for pain in non-ventilated infants

BACKGROUND: Critically ill newborn infants undergo a variety of painful procedures or experience a variety of painful conditions during their early life in the neonatal unit. In the critically ill paediatric and neonatal population, clonidine is prescribed as an adjunct to opioids or benzodiazepines aiming to reduce the doses of these drugs that are required for analgesia or sedation, or to facili

Assessing glacier retreat and its impact on water resources in a headwater of Yangtze River based on CMIP6 projections

Glacier retreat caused by global warming alters the hydrological regime and poses far-reaching challenges to water resources and nature conservation of the headwater of Yangtze River, and its vast downstream regions with dense population. However, there is still lack of a robust modeling framework of the “climate-glacier-streamflow” in this water tower region, to project the future changes of glac

Testing self-adaptive software with probabilistic guarantees on performance metrics

This paper discusses the problem of testing the performance of the adaptation layer in a self-adaptive system. The problem is notoriously hard, due to the high degree of uncertainty and variability inherent in an adaptive software application. In particular, providing any type of formal guarantee for this problem is extremely difficult. In this paper we propose the use of a rigorous probabilistic

On minimal unsatisfiability and time-space trade-offs for k-DNF resolution

A well-known theorem by Tarsi states that a minimally unsatisfiable CNF formula with m clauses can have at most m - 1 variables, and this bound is exact. In the context of proving lower bounds on proof space in k-DNF resolution, [Ben-Sasson and Nordström 2009] extended the concept of minimal unsatisfiability to sets of k-DNF formulas and proved that a minimally unsatisfiable k-DNF set with m formu

The possibilities of bush fallows with changing roles of agriculture - An analysis combining remote sensing and interview data from Sudanese drylands

The lengths of fallows have decreased in many parts of the Sahel due to agricultural expansion, which can have negative impacts on crop production when few other ways to improve soil fertility exist. However, the dynamics of agricultural expansion may change because of the changing role of agriculture in society due to increased livelihood diversification outside of agriculture. The results of thi

Feasibility study of advanced nom-reduction by hollow fiber ultrafiltration and nanofiltration at a Swedish surface water treatment plant

Membrane technology, i.e., ultrafiltration and nanofiltration, is growing in popularity, as it is a space efficient alternative for surface water treatment. Two types of hollow fiber membranes were tested in a fully equipped and automated pilot at a Swedish water treatment plant. Raw water was treated by a nanofilter and by coagulation before an ultrafilter. Operation parameters recorded during th

Reversed Hysteresis during CO Oxidation over Pd75Ag25(100)

CO oxidation over Pd(100) and Pd75Ag25(100) has been investigated by a combination of near-ambient-pressure X-ray photoelectron spectroscopy, quadrupole mass spectrometry, density functional theory calculations, and microkinetic modeling. For both surfaces, hysteresis is observed in the CO2 formation during the heating and cooling cycles. Whereas normal hysteresis with light-off temperature higher

Is ambient heat exposure levels associated with miscarriage or stillbirths in hot regions? A cross-sectional study using survey data from the Ghana Maternal Health Survey 2007

It is well established that high ambient heat could cause congenital abnormalities resulting in miscarriage or stillbirth among certain species of mammals. However, this has not been systematically studied in real field settings among humans, despite the potential value of such knowledge for estimating the impact of global warming on the human species. This study sought to test the hypothesis that

Situating Faculty Development in the Clinical Workplace

Medical students’ access to clinical supervision when rotating through hospital workplaces and the quality of that supervision are and have been an area of growing professional and societal concern. Increased training measures targeted at supervising physicians have been suggested to address this issue. Traditionally, such training has focused on offering physicians opportunities to develop as sup

Required Capabilities in a Logistics Relationship - A Case Study

This paper studies a newly developing relationship of closer collaboration between a buyer and supplier of a low complexity product, which cannot be considered strategic but of high volume, in the grocery retailing industry, The reason for studying this relationship is that the buyer has decided to go through with is program aimed at establishing is closer relationship with the supplier in the ca

Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: A meta-analysis of randomized clinical trials

BACKGROUND:Although oxygen therapy has been used for over a century in the management of patients with suspected acute myocardial infarction (AMI), recent studies have raised concerns around the efficacy and safety of supplemental oxygen in normoxaemic patients.OBJECTIVE:To synthesise the evidence from randomised controlled trials (RCTs) that investigated the effects of supplemental oxygen therapy

Qualitative modelling of functional relationships in marine benthic communities

In order to better understand and predict the dynamics of benthic macroinvertebrate communities, we need to first define the functional components of benthic biodiversity and then provide a mechanistic description of how they interact with their abiotic environment, their basic resources and each other. These interactions should be largely controlled by readily available biological traits, making