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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA expression due to glycemic status, which could contribute to the development of type 2 diabetes (T2D). To this end, miRNAs were identified by a combinatio
Recent work in cognitive science argues for the illusory nature of conscious will and considers occasional “blindness” to manipulations as indicative of our lack of awareness in choice making (e.g., Dennett, 1996; Johansson et al., 2013; Wegner, 2018). This claim is based upon the tendency of experimental participants not to detect such manipulations, and the similarity between verbal justificatio
Background and objectiveAtrioventricular valve disease is a common cause of heart failure, and successful surgical or interventional outcomes are crucial. Patient-specific fluid-structure interaction (FSI) modeling may provide valuable insights into valve dynamics and guidance of valve repair strategies. However, lack of validation has kept FSI modeling from clinical implementation. Therefore, thi
RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t
Introduction: Cerebrovascular reactivity imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow in response to a controlled vascular stimulus. The principal utility is the capacity to evaluate the cerebrovascular reserve, thereby elucidating autoregulatory functioning. In CVR, CO2 gas challenge is the most prevalent method, which elicits a vascular response by al
Cultural and creative activities are today described as central to regional and urban development by politicians and governments. Creative city policies are often aiming at economic benefits for the city itself, and there are normative purposes with many research studies as well as projects undertaken (Eckardt 2005; Markusen and Gadwa 2010; Kovacs 2011). Creative city policy is often oriented towa
The close relationship between young children’s living conditions and their healthlater in life is well documented and a safe and healthy environment during earlychildhood promotes cognitive functions and social development during the wholelifespan. Becoming a parent is a major life transition and it is sometimes described as a stressful and vulnerable time involving changes to lifestyle and routi
A systematic study was conducted over six years (1994-1999) on a shallow ice covered lake in the Russian Republic of Karelia with the aim of developing better understanding of some physical processes occurring in shallow ice-covered lakes. The average ice-covered period was 182 days while the longest ice-covered period was 193 days. The average lake water temperature at ice formation was 0.5-10deg
AIMS: To investigate the effects of parenteral administration of MgSO4, and glucose, insulin, and potassium (GIK), on the dominant atrial cycle length during chronic atrial fibrillation (CAF). METHODS AND RESULTS: The length of the dominant atrial cycle (DACL) in the power-frequency spectrum of the QRST-suppressed lead V1 ECG was identified before and after intravenous administration of MgSO4 alon
The study evaluates the factor structure and predictive validity of the symptom questionnaire EUROQUEST (EQ) that had been developed with the goal of simplifying the evaluation of health effects associated with long-term solvent exposure. The EQ was added to the normal evaluation procedures for 118 male patients with suspected solvent-induced toxic encephalopathy (TE) referred to seven Swedish cli
OBJECTIVE: To determine the incidence of acute thrombo-embolic occlusion of the superior mesenteric artery (AOSMA) in a population-based study. MATERIAL: All clinical (n=23,446) and forensic (n=7569) autopsies performed in the city of Malmo between 1970 and 1982 (population 264,000-230,000 inhabitants). The autopsy rate was 87%. METHODS: Calculation of the incidence of AOSMA with intestinal gangre
The purposes of this study were: (i) to determine the test-retest reliability of isokinetic ankle dorsiflexor strength measurements in young healthy adults using the Biodex dynamometer, and (ii) to examine several statistical measures for the interpretation of reliability. Thirty men and women (mean age 23 +/- 3 years) performed three maximal concentric contractions at 30 degrees/s, 60 degrees/s,
Breeding synchrony is hypothesised to influence the occurrence and frequency of extra-pair fertilisations (EPFs) in birds irrespective of the social mating system. The two proposed hypotheses make opposite predictions. (1) Synchronous breeding leads to a lower frequency of EPFs because males face a trade-off between mate guarding and obtaining additional matings via extra-pair copulations (EPCs) (
Based upon earlier experimental work by our group, we have started a human immuno-gene therapy study. The goal is to study the effects of immunisation with autologous tumour cells expressing gene sequences for human interferon-gamma For more than two decades we have sought for efficient treatment against malignant gliomas. Our most successful treatment in the animal models is immuno-gene therapy w
The monoclonal antibody 10E4, which recognizes an epitope supposed to contain N-unsubstituted glucosamine, is commonly used to trace heparan sulfate proteoglycans. It has not been fully clarified if the N-unsubstituted glucosamine is required for antibody recognition and if all heparan sulfates carry this epitope. Here we show that the epitope can contain N-unsubstituted glucosamine and that nitri
Popular Abstract in Swedish Under 1900-talets inledande decennier genomfördes fältarbeten på den svenska landsbygden då äldre bebyggelse och byar dokumenterades på bild och i ord. Dessa dokumentationer ingick i ett större sammanhang, där ambitionen var att alla aspekter av en förmodat försvinnande allmogekultur skulle kartläggas, samlas in och arkiveras. By- och bebyggelsedokumentationerna utfördeIn the first decades of the twentieth century there were fieldwork expeditions in rural Sweden, documenting archaic buildings and villages in words and pictures. These documentation efforts were part of a larger context, where the ambition was to survey and collect all aspects of what was presumed to be a vanishing peasant culture. The documentation was carried out by several different museums and
Desertification, climate variability and food security are closely linked through drought, land cover changes, and climate and biological feedbacks. In Ghana, only few studies have documented these linkages. To establish this link the study provides historical and predicted climatic changes for two drought sensitive agro-ecological zones in Ghana and further determines how these changes have influ
Popular Abstract in Swedish I Sverige insjuknar två barn i autoimmun diabetes (typ 1 diabetes) varje dag. Typ 1 diabetes (T1D) är en kronisk autoimmun sjukdom som kan få livshotande konsekvenser vid utebliven behandling. Sverige har den högsta incidensen av T1D i hela världen efter Finland. Förutom att den delvis är ärftlig vet man inte vilken eller vilka faktorer som triggar sjukdomen. Sedan mittType 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. The single nucleotide polymorphism (SNP) rs13266634 in th
