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Approximately 5% to 10% of melanoma may be hereditary in nature, and about 2% of melanoma can be specifically attributed to pathogenic germline mutations in cyclin-dependent kinase inhibitor 2A (CDKN2A). To appropriately identify the small proportion of patients Who benefit most from referral to a genetics specialist for consideration of genetic testing for CDKN2A, We have reviewed available publi
Simulations of a cumulonimbus cloud observed in the Cirrus Regional Study of Tropical Anvils and Cirrus Layers-Florida Area Cirrus Experiment (CRYSTAL-FACE) with an advanced version of the Explicit Microphysics Model (EMM) are presented. The EMM has size-resolved aerosols and predicts the time evolution of sizes, bulk densities and axial ratios of ice particles. Observations by multiple aircraft i
This thesis concerns the usage of large pollen databases and their application to mapping and modelling past vegetation. Maps of past taxon distributions are generated and classification techniques are used to compile maps of past woodland types. These visualisations of pollen data have applications in forest ecology and in modelling the impacts of climate change. Maps of the distribution limits o
Radiotherapy to the head and neck region leads to severe side effects in the oral cavity but knowledge about severity and onset is scarce among oncology nurses in a radiotherapy department. The aim was to test the Oral Assessment Guide for reliability and validity for patients receiving radiotherapy to the head and neck region. A prospective design with repeated assessments was selected. Thirty-si
We study and solve the previously unstudied problem of finding both sender and receiver positions from time of arrival (TOA) measurements when there is a difference in dimensionality between the affine subspaces spanned by receivers and senders. Anchor-free TOA network calibration has uses both in sound, radio and radio strength applications. Using linear techniques and requiring only a minimal nu
The interaction of molecules with their environment has a profound effect on dynamics in molecular systems. System-bath interactions, or the interaction of electronic and nuclear degrees of freedom, are important in order to understand chemical reactions and transport of energy and electrons in the condensed phase. In order to investigate system-bath interactions one needs to probe the underlying
Among the formats introduced in Swedish radio in the 1930s, the theatre series about contemporary family life has turned out an exceptional survivor. The first family series, ”Ingenjör Björck med familj” (1936-1943), was followed by 22 related series during the rest of the 20th century, each cultivating its own intimate and ritual based bond with the listeners. The dissertation ”Höra hemma. Familj
Popular Abstract in Swedish När vi ser oss omkring i naturen är det lätt att överväldigas av den otroliga variationen i olika former, färger och mönster som förekommer. Var kommer all denna variation ifrån? Samma fråga ställde sig Charles Darwin för mer än 150 år sedan – svaret publicerade han 1859 i sin bok ”Om arternas uppkomst”. Evolution är den process som genom selektion gynnar vissa egenskapOur knowledge of the evolutionary potential of traits involved in different selective episodes, especially in natural populations, is still limited. This is true for questions such as the genetic basis and inheritance of traits, how natural and sexual selection acts on them, and how selective conflicts influence the evolutionary response to selection. In my thesis, I investigate these questions, u
Popular Abstract in Swedish Den globala landbaserade kolcykeln reglerar mängden växthusgaser i atmosfären. För närvarande tas varje år 25-30% av våra utsläpp upp av de landbaserade ekosystemen vilket är en viktig ekosystemtjänst som kanske inte kommer att bestå i längden. Upptagskapaciteten av både hav och landbaserade ekosystem tenderar att försvagas av global uppvärmning. Detta leder till att enThe global terrestrial carbon cycle plays a pivotal role in regulating the atmospheric composition of greenhouse gases. Currently it is responsible for removing 25-30% of our emissions every year, an important ecosystem service that may not persist in the long term. Global warming tends to decrease the CO2 sink capacity of the world’s oceans and ecosystems leading to a larger fraction of our emiss
Popular Abstract in Swedish Under de senaste åren har det varit möjligt att skönja hur fenomenet eller begreppet varumärken har spridits från den traditionella marknadsföringsdiskursen och marknadsförare till varnliga konsumenter och deras vardagsdiskurs. Konsumenter kan därför förväntas besitta någon form av förståelse för hur märken som fenomen fungerar. Denna studie fokuserar på hur en sådan vaDuring the recent years the concept or phenomenon of brands and the importance ascribed to them by the traditional marketing discourse seems to have spread to the every day discourse of ordinary consumers. Consumers are therefore thought to posses some kind understanding of how brands as a phenomenon work. This study sets out to investigate how consumers construct such a brand understanding, and w
Molecular dynamics (MD) simulations give atomically detailed information on structure and dynamics in amphiphilic bilayer systems on timescales up to about 1 μs. The reorientational dynamics of the C-H bonds is conventionally verified by measurements of (13)C or (2)H nuclear magnetic resonance (NMR) longitudinal relaxation rates R1, which are more sensitive to motional processes with correlation t
The eyes of cuttlefish (Sepia officinalis) have a modified horizontal slit-pupil with a distinctive W-shape in bright light, while in darkness the pupil is circular. Two suggestions have previously been made for a function of the W-shape: (1) camouflaging the eye; (2) providing distance information. Since neither of these suggestions can fully explain the function of this pupil across the entire v
ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to
In this article career as metaphor and various career models are the object of a critical review. The question at issue is whether career as mataphor helps us understand the social dynamics that characterize substance abuse? Different models such as the stepping-stone and gateway hypothesis and H S Beckers career model is scrutinized. It is pointed out that these career models are one-sided and h
Fengycin is a biologically active lipopeptide produced by several Bacillus subtilis strains. The lipopeptide is known to develop antifungal activity against filamentous fungi and to have hemolytic activity 40-fold lower than that of surfactin, another lipopeptide produced by B. subtilis. The aim of this work is to use complementary biophysical techniques to reveal the mechanism of membrane perturb
Integrity of cartilage fails in joint disease. The current work aimed to identify candidate active proteinases in joint diseases using an in vitro model for cartilage degradation induced by interleukin-1. A critical event in the process of cartilage destruction in joint disease is the failure of the collagen fiber network to maintain integrity. Proteins binding to the surface of the fibers are lik
The role of the retention coefficient (i.e. the fraction of a dissolved trace gas which is retained in hydrometeors during freezing) for the scavenging and redistribution of highly soluble trace gases by deep convective cloud systems is investigated using a modified version of the Weather Research and Forecasting (WRF) model. Results from cloud system resolving model runs ( in which deep convectio
