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The notion ‘textual history’ (Sw. texthistoria) has often been used in a narrow philological sense denoting the history of version of a single work. Today it is however, at least in the Nordic languages, used in other connections as well, not least within discourse analysis. The article shows that textual history theoretically could be understood as (1) the history of text(s) as language in use, w
Popular Abstract in Swedish Kostnaden för utveckling och validering av produktionsanläggningar är idag ett stort problem för farmaceutisk industri. Valideringen innebär normalt en stor experimentell arbetsinsats. Den stora mängden experimentellt arbete innebär att det utvecklas färre läkemedel och till högre kostnad idag jämfört med tidigare. FDA har uppmärksammat detta i sitt PAT initiativ. En m
Popular Abstract in Swedish Avhandlingen består av tre empiriska uppsatser inom internationell finansiell ekonomi. Den ekonometriska gemensamma nämnaren är att samtliga använda modeller är av komplex multivariat natur. Därför föreslås att de ekonometriska modellerna estimeras med hjälp av simulated annealing, en stokastisk optimeringsalgoritm som potentiellt löser de problem som vanligtvis är förkThis thesis consists of three self-contained empirical studies on international financial economics. The common economic theme is that all three studies deal with international stock market return and risk. The common econometric theme is that all estimations are performed using simulated annealing, a stochastic optimization algorithm in the Markov Chain Monte Carlo family, in an attempt to solve
BACKGROUND: Among the textile dyes, disperse dyes are common sensitizers. OBJECTIVE: To investigate whether patch testing with a textile dye mix consisting of eight disperse dyes would be equivalent to testing with the separate ingredients of the mix at the concentrations used in the mix. METHODS: Researchers tested 1,780 consecutive patients with a mix consisting of Disperse Blue 35, Disperse Yel
PowerPoint-presentation STAFF MEETING CEC, INES & GEOLOGY 2024-11-28 2025: Towards the formation of Department of Earth and Environmental Sciences September 25, 2024 The Board of the Faculty of Science has decided that the Centre for Environmental and Climate Science (CEC), the Department of Physical Geography and Ecosystem Science (INES), and the Department of Geology will be co-organized into a
https://www.science.lu.se/internal/sites/science.lu.se.internal/files/2024-12/staff-meeting-mgeo-241128.pdf - 2026-06-17
Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when
BACKGROUND: Critically ill newborn infants undergo a variety of painful procedures or experience a variety of painful conditions during their early life in the neonatal unit. In the critically ill paediatric and neonatal population, clonidine is prescribed as an adjunct to opioids or benzodiazepines aiming to reduce the doses of these drugs that are required for analgesia or sedation, or to facili
Cartridge cases are often the sole items left behind after a shooting incident and DNA traces from these can identify persons connected to the shooting. However, the chance of retrieving usable DNA profiles from cartridge cases is limited, due to the low amounts of deposited DNA and subsequent DNA loss associated with the firing process. In the current study, we set out to increase the DNA recover
Population ageing is one of the most challenging social, demographic and economic phenomena affecting our societies, and policy makers and researchers have been developing diverse responses to address its consequences. During the last decades, within the EU context a new concept has been developed under the label of Active Ageing (AA), intended as a tool to support efforts aimed at adapting the so
Objectives To investigate outcome after septal myectomy and to evaluate long-term hemodynamics with exercise echocardiography. Methods This study included 40 consecutive patients operated with septal myectomy for hypertrophic obstructive cardiomyopathy from January 1998 to August 2017 at Skane University Hospital, Lund, Sweden. Perioperative clinical data and echocardiography measurements were rev
During the last decades, the science of remote sensing of the Earth's surface has produced an enormous amount of data. In parallel, with the increase in computational capacity, several classification methods have been applied to the satellite retrievals. This timely combination allows recovering more accurate knowledge about the land cover maps of past times. Therefore, the main goal of this work
The rapid advancement of medicine, fueled by big data and interdisciplinary research, has significantly transformed the landscape of computational oncology research. In this evolving environment, effective time management strategies are essential for researchers across diverse specializations. Computational oncology researchers typically pursue one of three primary career paths: clinical medicine,
Characterizing the onset and progression of Alzheimer’s disease pathologies relative to one another is important for biological staging and clinical trial design. Recent advances in blood plasma assays of Alzheimer’s disease amyloid and tau pathology have enabled detection of Alzheimer’s disease pathophysiology during life, but it remains unclear when plasma biomarker abnormalities are detectable
OBJECTIVES: To characterise autoimmune congenital heart block (CHB) associated with a maternal diagnosis of primary Sjögren's syndrome (pSS) confirmed either before, concomitant or after the first pregnancy complicated with CHB.METHODS: The following inclusion criteria were applied: (i) Mothers with positive Ro/La autoantibodies detected previously or at the time of diagnosis of the first case of
In 2015, FIGO revised the 1987 intrapartum cardiotocography (CTG) classification (FIGO1987). A less radical FIGO2015 version was introduced in Sweden 2017 (SWE2017). Now, post hoc simulation studies show that FIGO2015 and SWE2017 are less reliable than (a modified) FIGO1987. FIGO2015 shows significantly better interobserver agreement for normal CTG traces than FIGO1987, but significantly worse for
Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions. Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Un
Establishing a solid chronological framework for Arctic marine sediments is a critical first step towards glacial and palaeoceanographic reconstructions. However, this has historically been more challenging than elsewhere in the world, and often results in core chronologies and subsequent paleoenvironmental reconstructions being questioned and overturned. Optically stimulated luminescence (OSL) da
Aims/hypothesis: The aim of this study was to determine whether BMI in early childhood was affected by the COVID-19 pandemic and containment measures, and whether it was associated with the risk for islet autoimmunity. Methods: Between February 2018 and May 2023, data on BMI and islet autoimmunity were collected from 1050 children enrolled in the Primary Oral Insulin Trial, aged from 4.0 months to
In an often quoted sentence of his 1976 book "The Architecture of Form", Lionel March drew a clear distinction between science, interested in extant forms, and design, which initiates novel forms. The theories, methods, measures and diagrams of space syntax have often developed following this first more scientific scheme, and they have been concerned with the analysis of existing or projected buil
