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Galectins are a family of carbohydrate recognition proteins involved in modulation of cell signaling and cell adhesion. galectin-9 especially is involved in regulation of the immune response. In this work, galectin-9N inhibitors have been designed, synthesized and evaluated. The aim was to synthesize compounds with higher affinity than currently known compounds. Three compounds were synthesized wi
Att omplacera en arbetstagare kan vara ett sätt för en arbetsgivare att komma till rätta med samarbetssvårigheter på en arbetsplats. Omplaceringsrätten är en del av arbetsgivarens bestämmanderätt, som utgör ett viktigt fundament i svensk arbetsrätt, men begränsas bland annat av gränsen för arbetstagarens arbetsskyldighet. Till följd av Arbetsdomstolens avgörande i mål AD 1978 nr 89 kom arbetsgivar
Syftet med studien var att utforska hur personer med psykisk ohälsa beskriver betydelsen av att blogga om personliga erfarenheter. Semistrukturerade intervjuer genomfördes med fem personer som lever med psykisk ohälsa och skriver en blogg om det. Materialet analyserades utifrån tolkande fenomenologisk analys (IPA). Analysen av intervjuerna resulterade i fyra huvudteman som skildrar bloggens betydeThe aim of this study was to explore the meaning of blogging about lived experience as described by people living with mental illness. Semi-structured interviews were conducted with five people and the content was analyzed using interpretative phenomenological analysis. This resulted in four main themes depicting what blogging meant to the participants in terms of well-being and self-image: The bl
Bombus terrestris is one of the most commonly used insect models to investigate visually guided behavior and spatial vision in particular. Two fundamental measures of spatial vision are spatial resolution and contrast sensitivity. In this study, we report the threshold of spatial resolution in B. terrestris and characterize the contrast sensitivity function of the bumblebee visual system for a dua
The crystal structures of the binary cadmium-rich complex metal alloys NiCd6+delta (-0.32 <= delta <= 0.35) and NiCd1+delta (0 <= d <= 0.05) were studied by means of single crystal X-ray diffraction. The partitioning of the NiCd6+delta structure into clusters grouped around all 16 high symmetry points of the face centered cubic cell leads to the identification of two partial structures forming rep
The aim of this study was to analyze in which ways the issue of privatization of welfare services has been reported and debated in Swedish media. More specifically its purpose was to explore how ideas and arguments were presented, and if the language use reflected ideological conceptions in the debate. The study was based on a selection of articles, collected from three of Sweden’s largest broadsh
Gruvavfall är världens största miljöproblem om man räknar i ton. Detta orsakar bland annat metallförorenat lakvatten samt försurning av mark och vatten. Gruvbrytning har förekommit i större skala sedan 1800-talet vilket har medfört stora mängder av avfall som tidigare deponerades i naturen utan hänsyn till miljön. Från deponier med gruvavfall transporteras vittringsprodukter (sulfat, syror och tunMine waste is the world’s largest environmental hazard, measured in tons. It causes acidification of soils and groundwater. Another hazard from mine waste deposits is the leakage of metals, which are transported to surrounding areas. Large-scale mining has occurred since the 19th century and it has produced enormous amounts of mine waste, often deposited without any concern of the environment. Fr
“Meetings are now more important” : A study about social workers' view on client meetings within the financial aid sector. In social work, meeting other people forms a big part of the job and human contact is generally considered very important. The aim of this study was to investigate how social workers within the financial aid sector reason about meetings with clients when based on the goal
We establish the central convergence properties of ordinary Dirichlet series, including the classical result by Bohr, providing uniform convergence of the series where it has a bounded analytic continuation. We also derive a lower bound for the supremum of Dirichlet polynomials using Kronecker's theorem, of which we see one proof. With this knowledge and some probability theory we can follow t
När man skapar en produkt är det inte ovanligt att olika målgrupper ska använda produkten. Detta medför att målgrupperna kommer att ha olika erfarenheter, och därmed riskera att skapa olika konceptuella modeller av produkten. Men en inkorrekt konceptuell modell kommer skapa inkorrekt beteende, därför behöver man se till de olika erfarenheterna och därifrån skapa en entydig lösning. Syftet med exam
Sammanfattning Syftet med denna uppsats är att undersöka om manligt nätverk har någon betydelse i svenska och europeiska rättsfall rörande asylsökande kvinnor som fruktar könsrelaterad förföljelse. Detta kommer undersökas genom att analysera flera rättsfall från migrationsdomstolar och Europadomstolen. Uppsatsen kommer även analysera två rättsfall från EU-domstolen och ett fall från MigrationsövSummary The purpose of this paper is to examine if and what value male network has in Swedish and European migration cases regarding women seeking asylum because of persecution based on their gender. This will be examined through analyzing several cases from the Swedish Migration Court and the European Court of Human Rights. This paper will also present two cases from Court of Justice of the Europ
Populärvetenskaplig sammanfattning Genetisk variation och genuttryck i Langerhanska öar Projekt 1 - Genetisk variation DNA är den mänskliga cellens informationslagringsenhet och består av långa sekvenser av de fyra nukleotiderna adenin(A), tymin(T), cytosin(C) och guanin(G). Proteiner kan binda till DNA och översätta delar av dessa sekvenser(gener) till RNA, en liknande typ av molekyl. RNA kanAbstract This article describes the creation of a pipeline for variant calling from high-throughput next-generation exome and RNA sequencing data using commonly used bioinformatics tools. High-throughput sequencing data from six pancreatic islet cell samples were analyzed using the pipeline, and the resulting variant calls were validated against chip genotyping data from the same individuals. The
Abstract: In 2011 Vinnova funded a joint project between Nordkalk AB, Kalkproduktion Storugns AB (KPAB) and the department of Geology at the University of Lund. The goal of the project is to increase the general knowledge of limestone and in extension, facilitate for the industry. This thesis is a part of the project and consists of two separate parts which look into the geochemistry and thermal p
European power generators are facing a powerful suite of drivers to engage in carbon capture and storage (CCS). However, the future for CCS is uncertain. The type and level of engagement will depend on how CCS develops. This work, based heavily on primary data, collected thoughts and opinions of 37 stakeholders in Northern Europe in the CCS field today encompassing power companies, NGOs, academics
