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Woolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes a

BACKGROUND: Predicting major post-operative complications is an important task for which simple and reliable methods are lacking. A simple scoring system based on intraoperative heart rate, blood pressure and blood loss was recently developed to fill this gap. This system, the Surgical Apgar Score, shows promising results both in terms of validity and in terms of usefulness. The goal of this study

Dynamic optimization is the problem of finding the minimum of a cost function subject to a constraint comprised of a system of differential equations. There are many algorithms to numerically solve such optimization problems. One such algorithm is multiple shooting. This paper reports an implementation of a multiple shooting algorithm in Python. The implementation is based on the open source platf

Background: Alzheimer’s disease (AD) is an insidiously progressive neurodegenerative disorder that is characterized by multiple cognitive impairments and gradual loss of independence in carrying out activities of daily living (ADL). Currently, the predominant therapy for mild-to-moderate AD is cholinesterase inhibitors (ChEIs), which have been shown to have positive effects on symptoms compared wi

More complex understanding of relationality in care networks around patients with life-limiting illness and their significant others is needed. This is the case not only because care is distributed unequally along gendered lines, but also because of the changing landscape of care in welfare states where families and communities are made more self-responsible. This study examines everyday experienc

Background Early life factors may predict cardiovascular disease (CVD), but the pathways are still unclear. There is emerging evidence of an association of early life factors with apolipoproteins, which are linked to CVD. The study objective was to assess the associations between birth variables and adult apolipoproteins (apoA1 and apoB, and their ratio) in a population-based cohort. Methods The L

This thesis explores Danish social workers' sensitivity to the risk of committing microaggressions towards nonbinary clients. The theoretical framework primarily relies on microaggression theory. As a point of departure, the author developed a Microaggression Scale for Nonbinary Clients, which includes eight microaggressions that nonbinary clients might experience from social workers. The empi

Arbetet undersöker vilken roll musik har i att förändra samhället, vad som utmärker musik som påverkar samhället, och på vilket sätt musiken påverkar. Detta görs med hjälp av en historisk grund och genom intervjuer av tre personer som har en inblick i att påverka genom musik. Målet är att arbetet ska ge en inblick i hur man kan påverka genom musik, för att sedan själv kunna börja påverka genom detThe essay examines what role music have in changing society, how music that affects society is different, and in what way the music makes a change. This is done through a historical base and through interviews with three people with an insight into influencing through music. The goal is that the essay will give an insight into how one can influence through music, so that the reader then can start

How do event-by-event temperature fluctuations in the quark–gluon plasma alter jet- quenching signatures? This thesis answered that question by using the simulation tool JEWEL with two different medium models. The first one was a more realistic, event-by- event ”lumpy” temperature profile in the plasma. The second one treated the medium as a smooth, average background instead. Jet quenching is the

Working life is continuously changing and there is a greater responsibility on the individual to be able to adapt to change. For employees to be able to take on this responsibility and to be high performers, organizations need their employees to have high work engagement. This study therefore investigated the relationship between work engagement, organizational change, and employees’ perception of

We report on a transport measurement study of top-gated field effect transistors made out of InSb nanowires grown by chemical vapor deposition. The transistors exhibit ambipolar transport characteristics revealed by three distinguished gate-voltage regions: In the middle region where the Fermi level resides within the bandgap, the electrical resistance shows an exponential dependence on temperatur

What does a sustainability project look like in the 21st century? Not the glossy version, but the naked truth? Tired of manicured, over-theorised accounts of the ‘musts’ and ‘shoulds’ of sustainability transitions, we got to the bottom of things; actually, to the very bottom of the project hierarchy: the individual. Our point of departure is that projects are nothing but temporarily interconnected

Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re

Föreliggande enkätstudie syftar till att utvärdera PIPP-skalans tillämpning i klinisk verksamhet genom att undersöka sjuksköterskors och barnsköterskors attityder till denna smärtskattningsskala för prematura barn. Enkätstudien genomfördes på neonatalavdelningen på Lunds Universitetssjukhus och utgår från totalt 53 formulär besvarade av 27 sjuksköterskor och 26 barnsköterskor. Studien visar att 77

Som musiker arbetar jag dagligen med kontrabasen som mitt huvudsakliga instrument. Och jag hade en grundläggande förståelse hur instrumentet fungerade. Men vad är det som gör varje enskilt instrument så unikt i fråga om klang och utformande? I den kommenterande delen av mitt examensarbete redogör jag för mig själv hur mitt huvudinstrument, kontrabasen är uppbyggd genom att själv bygga ett instrume

I samband med metoo-rörelsen dömdes ett flertal kvinnor för förtal efter att ha pekat ut sin påstådda förövare av sexuella trakasserier och övergrepp på olika medieplattforma. Gemensamt i många av målen var att sanningshalten i kvinnornas uttalanden aldrig blev föremål för prövning. Bristen på sanningsprövning i målen väckte i sin tur debatt där kritik riktades mot förtalsbestämmelsen – är den en In connection with the #MeToo movement, several women were convicted of defamation after having publicly identified their alleged perpetrators of sexual harassment and assault. A common factor in many of these cases was that the truthfulness of the women’s statements was never subjected to judicial review by the courts. The absence of truth assessment in the cases has since sparked debate with cri