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Background: Nordic Lymphoma Group has conducted a phase ll trial in primary central nervous system lymphoma patients applying age-adjusted multi-agent immunochemotherapy regimen, which in elderly patients included temozolomide maintenance treatment. Design and Methods: Patients with newly diagnosed PCNSL aged 18-75 years were eligible. Sixty-six patients (median age 64 years) were enrolled. Two ag
Chloroplast gene expression is regulated by developmental and environmental signals. It has been proposed that there is a direct coupling between electron transport in biological membranes and gene expression (J. F. Allen, 1992, Biochim. Biophys. Acta 1098, 275-335). The hypothesis predicts the existence of a sensor in the thylakoid membrane capable of transmitting redox signals to the chloroplast
Background Balloon kyphoplasty is a minimally invasive procedure for the treatment of painful vertebral fractures, which is intended to reduce pain and improve quality of life. We assessed the efficacy and safety of the procedure. Methods Adults with one to three acute vertebral fractures were eligible for enrolment in this randomised controlled trial at 21 sites in eight countries. We randomly as
Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteop
Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re
Objectives: The novel MOTor Imagery to Facilitate Sensorimotor Re-Learning (MOTIFS) model takes a uniquely holistic approach by integrating mental and physical aspects into current training programs. The aim of this trial was to evaluate enjoyment of MOTIFS training as compared to Care-as-Usual (CaU) knee injury and/or rehabilitation training. The primary hypothesis was that enjoyment would be gre
Background: Since its discovery in 2007, the importance of the human gut bacterium Prevotella copri (P. copri) has been widely recognized with its links to diet and health status and potential as next generation probiotic. Therefore, precise, convenient and cost-effective diagnostic tools for the detection and quantification of P. copri from clinical and environmental samples are needed. Results:
This panel is devoted to an exploration of multimodal, visual staging of meaning in the Middle East and its transnational interconnectedness. Presentations will discuss examples of visual inventiveness in different and multimodal medial contexts, varying both in terms of motivations, positions of power and visual strategies employed. The panel invites reflection on how the study of current visual
This dissertation acknowledges that accountability of educators for the grades they assign is a part of the foundation for a meritocratic society, based on fairness in judging merit and, therefore, in assigning grades. In this view, any grade obtained by any student must be both reliable and valid. This, in turn, implies that the process of assessment of students’ work on which the grade is based
Twelve children with a severe form of haemophilia A received a totally implantable venous access system (Port-A-Cath) to facilitate regular prophylactic treatment with factor VIII. The indication for implantation was difficulty in obtaining regular access to a peripheral vein. Postoperative bleeding around the portal site occurred in two of 12 cases. After a median duration of follow-up of 26 mont
Roma and Travellers (”resande”) have been present in Sweden for centuries. In the 19th and early 20th centuries, rural municipalities (kommuner) often adopted policies aimed to expel them from or to prevent them from entering the municipality. This is well established by previous research. What is less known is that another kind of territorial exclusion existed as well: that of collective violence
Background ST-elevation myocardial infarction (STEMI) occurs as a result of rupture of an atherosclerotic plaque in the coronary arteries. Limited data exist regarding the impact of culprit coronary vessel on hard clinical event rates. This study investigated the impact of culprit vessel on outcomes after primary percutaneous coronary intervention (PCI) of STEMI.Methods A total of 29 832 previousl
Aim: This study examined medical and psychosocial risk factors in children born to women with addiction problems during pregnancy and the children's needs for extra medical and psychosocial resources. Methods: Swedish midwives routinely screen pregnant women for drugs and alcohol and refer women with addictions to the Maternity and Child Healthcare Resource Team. We investigated the medical record
The Barnahus model was launched in Iceland in 1998, and it subsequently spread to all the Nordic countries. It is an interagency, co-located model for working with cases of violence and abuse against children that addresses two vital concerns of welfare societies: to process cases through the legal system and to offer support and treatment to victims. The model is currently recommended as a best-p
The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information abo
