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The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individually matched remission samples as controls, and all
Flexible parking requirements have been introduced in several Swedish city governments in recent years. Through qualitative interviews with traffic engineers, learnings from these years have been compiled and then compared with a literature review. The flexibility de-sign and required mobility management measures varies from detailed to free, and results show that different engineers prefer differ
The textile product industry has many challenges and all designers creating products using textiles will have an impact on the environmental sustainability in the world. The project investigates state of the art textile product design today, the challenges of environmental sustainability in the future and how the designer plays a role in making a positive difference. Qualitative research was done
Det finns ingen offentligrättsligt reglerad möjlighet att tvångsadoptera ett familjehemsplacerat barn i Sverige. Den mest ingripande åtgärden som offentliga myndigheter och organ kan vidta inom ramen för lag (1990:52) med särskilda bestämmelser om vård av unga är en vårdnadsöverflyttning från barnets biologiska föräldrar till familjehemsföräldrarna. I fråga om tvångsvård av barn är den civilrättsl
Many children are being investigated every year within the Swedish social services and criticism has been directed at the investigations' lack of quality and legal certainty in recent years. The criticism is also about how different Swedish municipalities assess and investigate. How can these differences be explained? What are the grounds for the assessments? This is the background to this qua
This report provides a detailed study of attic fires that have occurred in Swedish apartment buildings in order to determine if there are specific technical or organizational factors that influence them. The study has been carried out by a combined analysis of rescue service statistics with case studies based on detailed fire investigations. In the case study a total of 27 fire investigations w
Dedicated clinics have been established for the early diagnosis and treatment of women at risk for inherited breast cancer, but the effects of such interventions are currently unproven. This second report on prospectively diagnosed inherited breast cancer from the European collaborating centres supports the previous conclusions and adds information on genetic heterogeneity and the effect of oophor
In order to find sensitizers additional to the current fragrance mix (FM) a series of fragrance materials (series II) was evaluated in 6 dermatological centres in Europe. 11 of the test materials were essential oils, the remaining 7 being either mixtures of isomers or simple chemicals of frequent usage in the perfume industry. 1606 patients were consecutively tested with series II and 8% FM. Each
This paper introduces a model of the atrioventricular node function during atrial fibrillation (AF), and describes the related ECG-based estimation method. The proposed model is defined by parameters that characterize the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two atrioventricular nodal pathways, the refractory periods of these pathways, and the p
BACKGROUND: Seed galactomannans are preferred hydrocolloids since they are comparatively cheap, non-toxic, eco-friendly and non-polluting during production and application. Galactomannans from seeds of three species of Gleditsia, namely G. sinensis, G. microphylla and G. melanacantha, were characterized in terms of structural and thermal properties. RESULTS: Gleditsia polysaccharides were characte
Oversharing of information about one's private life or the private lives of others appears to be an oft-noted phenomenon in the context of social media. This paper aims at answering the following question: What is it in social media as media and in the communicative situation of the person using them that facilitate oversharing of private information? A comparative analysis of face-to-face interac
Background: The use of inhaled corticosteroids (ICSs) is associated with an increased risk of pneumonia in patients with COPD. However the risks of other respiratory infections such as TB and influenza remain unclear. Methods: Through a comprehensive literature search of MEDLINE EMBASE CINAHL Cochrane Library and ClinicalTrials.gov from inception to July 2013 we identified randomized controlled tr
Background: Food consumption is one of the most important drivers of environmental pressures. Adoption of healthy diets is suggested to be an option for less environmentally intensive food habits and improved public health. In particular, changes in meat consumption are believed to bring potential benefits. Objective: To quantify the impact of changes in meat consumption on the dietary contributio
Beta-microseminoprotein (MSP) is one of the most abundant proteins secreted by the prostate gland. Because MSP is also synthesized in nonreproductive organs, the establishment of a solid relationship between the levels of MSP in serum and semen is crucial for future studies connecting MSP with aging or diseases of the prostate gland. We developed a specific, competitive, europium-based immunoassay
The present intervention was designed to investigate whether a 14-week period of regular recreational association football (F) or endurance running (R) has an effect on the risk of falls and bone fractures due to gains in muscle function and volumetric bone mineral density (vBMD). Fifty healthy untrained Danish premenopausal women were randomized into two training groups (F and R) that trained 1.8
The purpose of this master thesis is to investigate the difficulties that arise in the construction process by analyzing documentations from real-life construction processes that occurred in four municipally in Skåne. By mapping out all the problems that arise, opportunities for improvement will be obvious and thus efficiency solutions can be proposed. After a conversation with a control inspector
