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The myeloid translocation gene 16 product MTG16 is found in multiple transcription factor-containing complexes as a regulator of gene expression implicated in development and tumorigenesis. A stable Tet-On system for doxycycline-dependent expression of MTG16 was established in B-lymphoblastoid Raji cells to unravel its molecular functions in transformed cells. A noticeable finding was that express
Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.
The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. To test this concept, two previously published independent data sets on wounded human epidermis were re-analyzed. The prese
Clear-cell renal cell carcinoma (RCC) is, in most cases, caused by loss of function of the tumor suppressor gene von Hippel-Lindau, resulting in constitutive activation of hypoxia-inducible factor (HIF)-1 alpha and expression of hypoxia-induced genes in normoxic conditions. Clear-cell RCC cells are characterized histologically by accumulation of cholesterol, mainly in its ester form. The origin of
Assessment of clinical risk factors for haemorrhagic complications in patients undergoing intra-arterial thrombolysis for lower limb ischaemia. Retrospective reviews of consecutive patients subjected to intra-arterial thrombolysis due to lower limb ischemia at the Vascular Center, Malmö University Hospital, during a 5-year period from 2001 to 2005. Two hundred and twenty intra-arterial thrombolyti
Oversharing of information about one's private life or the private lives of others appears to be an oft-noted phenomenon in the context of social media. This paper aims at answering the following question: What is it in social media as media and in the communicative situation of the person using them that facilitate oversharing of private information? A comparative analysis of face-to-face interac
Gluco-incretin hormones increase the glucose competence of pancreatic beta-cells by incompletely characterized mechanisms.
The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal models of cardiac disorders are translatable to human disease. Mitochondria were rapidly isolated from fresh atrial tissue samples obtained from 14 patie
Background: To linguistically validate and culturally adapt the Evaluation of Daily Activity Questionnaire (EDAQ) for use in rheumatoid arthritis (RA) from Swedish to British English. The EDAQ is a patient reported outcome measure of daily activity ability. It includes 11 activity domains (Eating and Drinking; Personal Care; Dressing; Bathing; Cooking; Moving Indoors; House Cleaning; Laundry; Movi
The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators and underlie the enhancement of mitochondrial function described in the later phase of sepsis. Therefore, we investigated the correlation between observed changes in platelet mitochondrial respiration and a set of pro- and anti-inflammatory cy
Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e
Immune responses against oxidized low density lipoprotein (LDL) play a key role in atherosclerosis. Previous studies have indicated inverse associations between autoantibodies to epitopes in oxidized LDL and cardiovascular disease. In this study we investigated the associations between autoantibodies against the apolipoprotein B-100 (apoB-100) peptides p45 and p210 and occurrence of carotid plaque
This thesis investigated the potential of using reactive power compensation to solve overvoltage issues caused by high amounts of distributed generation, such as rooftop photovoltaic (PV) systems, in the low voltage grid. High voltages are caused by increasing distributed generation as the Swedish power grid shifts from centralised to decentralised power production. The aim was to manage overvol
Welcome address 2018 WORLD HUMAN RIGHTS CITIES FORUM GWANGJU Annual Theme: Whom Do We Live With? – Diversity, Inclusiveness, and Peace Global challenges, local solutions: Re-engaging human rights PROF MORTEN KJAERUM DIRECTOR, RAOUL WALLENBERG INSTITUTE OF HUMAN RIGHTS AND HUMANITARIAN LAW Firstly, I would like to thank Mr. LEE Yong-Seop, Mayor of the city of Gwangju for the invitation to speak her
https://rwi.lu.se/app/uploads/2018/10/Mortens-Opening-speech-Gwangju.pdf - 2026-07-07
Microsoft Word - Gruppövning 2.docx 1 Industri och imperier VT 2017 Gruppövning 2. Industrialiseringen Bakgrund Övningen syftar till att belysa några aspekter av de omfattande sociala och ekonomiska processer under 1700- och 1800-talen som ofta brukar omtalas som den industriella revolutionen, industrialiseringen eller industrialismen. Vi gör det genom att analysera två historiska källor från Engl
https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISA16/20171/Gruppvning_2.pdf - 2026-07-07
Stormwater from urban areas contain a number of pollutants, among which nitrogen and phosphorous have been of lesser focus. In this study I aim to investigate if biochar has the potential to fill the role as water filter in urban areas, and to pin point what should be experimentally investigated in order to evaluate biochar in comparison to two contemporary filter systems: bioreactors and chalk fi
This project was performed in collaboration with ArjoHuntleigh’s Innovation Centre in Malmö, Sweden, from January 2014 to June 2014. The objective of the thesis was to design and develop a movable or removable plate/shelf. The Project has been carried out by using the methodology described in the book “Product development and Design” by Ulrich and Eppinger. The methodology has been modified to fi
Abstract Several international instruments including CEDAW have recognized every human being to be free from any form of violence including being free from inhuman and degrading treatment. Equality of men and women is also recognized starting from the establishment of UN in 1945 under its charter. UDHR, ICCPR and ICSECR are the major international human right instruments which recognized the appl
