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Background--The relationship between "on-treatment" low platelet reactivity and longitudinal risks of major bleeding dual antiplatelet therapy following acute coronary syndromes remains uncertain, especially for patients who do not undergo percutaneous coronary intervention. Methods and Results--We analyzed 2428medicallymanaged acute coronary syndromes patients fromthe Targeted Platelet Inhibition

In this paper, computation fluid dynamics (CFD) simulations are employed to describe the effect of flow parameters on the formation of soot and NOx in a heavy duty engine under low load and high load. The complexity of diesel combustion, specially when soot, NOx and other emissions are of interest, requires using a detailed chemical mechanism to have a correct estimation of temperature and species

BACKGROUND: Non-communicable diseases (NCDs, e.g. cardiovascular disease) are responsible for high rates of morbidity and the majority of premature deaths worldwide. It is necessary to develop preventative interventions that can reduce the associated risk factors of NCDs. Researchers have found that the biomarker adrenomedullin (ADM) becomes elevated years before the onset of NCDs and might play a

Photoinduced electronic and structural changes of a hydrogen-generating supramolecular RuPt photocatalyst are studied by a combination of time-resolved photoluminescence, optical transient absorption, and X-ray absorption spectroscopy. This work uses the element specificity of X-ray techniques to focus on the interplay between the photophysical and -chemical processes and the associated time scale

INTRODUCTION: Administrative healthcare databases are useful to investigate the epidemiology, health outcomes, quality indicators and healthcare utilisation concerning peptic ulcers and gastrointestinal bleeding, but the databases need to be validated in order to be a reliable source for research. The aim of this protocol is to perform the first systematic review of studies reporting the validatio

Purpose: To describe a new time-saving threshold visual field–testing strategy—Swedish Interactive Thresholding Algorithm (SITA) Faster, which is intended to replace SITA Fast—and to report on a clinical evaluation of this new strategy. Design: Description and validity analysis for modifications applied to SITA Fast. Methods: Five centers tested 1 eye of each of 126 glaucoma and glaucoma suspect p

Objective: To describe the anatomy of uterine lymphatic drainage following cervical or fundal tracer injection to enable standardization of a pelvic sentinel lymph node (SLN) concept in endometrial cancer (EC). Methods: A prospective consecutive study of women with EC was conducted. A fluorescent dye (Indocyanine green) was injected into the cervix (n = 60) or the uterine fundus (n = 30). A system

The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine- 1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-activated kinase (AMPK), establishing a potential feedback link. In Baby Hamster Kidney (BHK) cells

The waiting list for lung transplantations world-wide is steadily growing. So, the use of lungs from non-heart-beating donors (NHBD) needs to be addressed. Hence, the aim of this thesis was to evaluate, in realistic animal models, the new donor organ concept: NHBD transplantation. Left rat lungs were topically cooled for 2 hours in situ after failed resuscitation, with subsequent transplantation.

In 2008-2009 Lund University, Sweden, took part in two European benchmarking projects on eLearning, E-xcellence+ (EADTU) and Benchmarking eLearning exercise2009 (ESMU) as part of the University’s policy for quality assurance and quality enhancement of education. Among the aims were · to adopt, as the first Swedish university, a benchmarking process according to quality criteria of eLearning formul

Alpha(1)-microglobulin is a 26 kDa plasma and tissue glycoprotein that belongs to the lipocalin protein superfamily. Recent reports show that it is a reductase and radical scavenger and that it binds heme and has heme-degrading properties. This study has investigated the protective effects of alpha(1)-microglobulin against oxidation by heme and reactive oxygen species in the human erythroid cell l

Background. The aim of the present study was to establish the magnitude and time-course of C-reactive protein increases following routine neurosurgical procedures in the absence of clinical and laboratory signs of infection. Method. C-reactive protein levels were studied daily following ventriculo-peritoneal shunt implantation, anterior cervical fusion, vestibular schwannoma operation, supratentor

New radiative lifetime measurements based on time-resolved laser-induced fluorescence techniques are reported for 18 even-parity levels belonging to the 4f5d(2)6p and 4f(2)5d(2) configurations of Ce I and 6 even-parity levels belonging to the 5d(2)6s, 4f5d6p, and 4f6s6p configurations of Ce II. Free neutral and singly ionized cerium atoms were produced by laser ablation. The Ce I and Ce II levels

We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contrala

This paper presents a new method to derive the tire forces for simultaneous braking and cornering, by combining empirical models for pure braking and cornering using brush-model tire mechanics. The method is aimed at simulation of vehicle handling, and is of intermediate complexity such that it may be implemented and calibratedby the end user. The brush model states that the contact patch between

Popular Abstract in Swedish Denna rapport behandlar trafiklaster på broar och de lasteffekter som de ger upphov till. Böjmoment och tvärkraft för olika brotyper beskrivs i form av statistiska fördelningar med tillhörande parametrar. Dessa är baserade på mätningar av verklig trafik gjorda i Sverige under åren 2002-2003 i Vägverkets regi. Resultaten finns redovisade i Vägverket (2004b), och finns laThis thesis treats traffic load effects in road bridges and in particular bending moment and shear force in different types of bridges. All traffic load effects are described in terms of statistical distribution functions for annual extreme values. The statistical distributions are based on measurements of real traffic, made in Sweden during 2002-2003. The measurements are managed by the Swedish R