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Limited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem cells and contributes to the relative quiescence and durability of the stem cell population in vivo. Here we report that the executioner Caspase, Caspase-3, unexpectedly participates in that process. Mice deficient in Caspase-3 had increased numbers of immunophenotypic long-term repopulating stem cells in ass

The Icelandic highlands are one of the few places left in Europe where tourists can experience pristine wilderness. During the past decades the highlands have, however, witnessed a rapid expansion in natural resource exploitation. This study attempts to evaluate the pristine condition of Icelandic wilderness by testing different methods of identifying and analysing wilderness with respect to natur

Background - The aim of the study was to evaluate the relation between maternal placental Doppler velocimetry, levels of the maternal glucose, and clinical signs of vasculopathy in pregnancy complicated by pregestational diabetes mellitus. Methods and Results - A retrospective study of 155 pregestational diabetic women between the 22nd and 40th weeks of pregnancy, categorized in White classificati

Daniel Cunha misreads us as suggesting that climate change has been a conscious and deliberate strategy of a global elite. This was very clearly not our suggestion. He proposes that the Marxian concept of fetishism is applicable to anthropogenic climate change, apparently unaware of our recurrent use of precisely this concept in a number of publications over the past decades. We thus fundamentally

Every child with severe or moderate haemophilia A or B, born in Sweden during the period 1970-1990, was traced in the national haemophilia register, all 117 case records being surveyed for mode of delivery and perinatal complications. Of the 117 deliveries. 13 were by caesarean section and the remaining 104 vaginal. Of the 13 caesarean sections, 2 were performed because the woman was a haemophilia

Dyslexia is a learning disability characterised by problems with accurate or fluent word recognition, poor decoding, and poor spelling abilities. Although several studies have addressed dyslexia and Web accessibility, less is known about how dyslexia affects information search. This study investigated whether the inclusion of icons in search user interfaces enhances performance among dyslexics. A

The cultural construction of the journey as a narrative of masculine identity poses problems for the conceptualization of the female traveller in general and of the female Russian migrant in particular. Three contemporary prose pieces dealing with women's migration reveal subtle and often sophisticated ways of playing with the stigmatization of Russian women as prostitutes and of destabilizing the

Introduction: This work aims to evaluate the possibility to transfer electrical power from a metal plate to the steel-cord within a car tire. If the tire stands on the plate, a connecting surface occurs which can be interpreted as a capacitor, where the rubber compound acts as a dielectric. Method: First the impedance of the tire is evaluated: An analytical model is set-up to describe the system;

The paper presents the theories of Peter Singer and Tom Regan concerning the moral status of animals and why both deem animals to have a moral standing similar to humans. The two theories differ in their approaches to justifying the moral standing of animals and humans but have very similar conclusions. The paper then goes on to show how both theories have potential problems in justifying that the

Aims: To assess the agreement between the Ross treadmill method and the Åstrand ergometer cycle method, and the repeatability of each method. Methodology: Twenty healthy people aged 22.5 ± 2.2 years were tested on two different days, each day with both methods with a pause of 30 min between the tests. The tests were executed in the reverse order the following test day. Major findings: There was no

Introduction: The screening program for cervical cancer in Sweden recommends the use of primary human papillomavirus (HPV) screening for women aged ≥30 to 65 years. Co-testing with both HPV analysis and cytology is recommended at the first screening after the age of 40 years. To fulfil co-testing, all screened women aged 40–42 years within the region of Skåne were co-tested. The aim of the audit w

BACKGROUND: Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET)

Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of H

Turkish President Erdogan is a faithful Muslim and strongly objects to getting/paying interest. To reduce the (high) inflation rate, he declared in a speech at Parliament: “As long as I am in office, I will fight interest. The NAS is there.” The primary purpose of this chapter is to shed light on the nature of this concept and to find out whether there is indeed a NAS with the specific aim of curb

Patients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1-2 years before diagnosis that can result in changes to medications. We investigate recent medication changes and PDAC diagnosis in Nurses' Health Study (NHS; females) and Health Professionals Follow-up Study (HPFS; males), including up to 148,973 U.S. participants followed for 2,994,057 person-years