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FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how
Objectives: To study in vivo gray matter (GM) volumes of the nucleus basalis of Meynert (nbM) in different parkinsonian syndromes and assess their relationship with clinical variables. Methods: T1-weighted magnetic resonance images from patients with progressive supranuclear palsy (PSP, N = 43), multiple system atrophy (MSA, N = 23), Parkinson’s disease (PD, N = 26), and healthy controls (HC, N =
As temperatures decrease in autumn, vegetation of temperate and boreal ecosystems increases its tolerance to freezing. This process, known as hardening, results in a set of physiological changes at the molecular level that initiate modifications of cell membrane composition and the synthesis of anti-freeze proteins. Together with the freezing of extracellular water, anti-freeze proteins reduce pla
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured with quantitative PET, may help to explain the phenotype of SCD. The aim of this study was to investigate whether quantitative amyloid-β load is associated with both
Chemical cross-linking combined with site-directed mutagenesis was used to evaluate the role of extracellular cysteines and their positions relative to the binding site for the agonist bradykinin (BK) in the human BK B2 receptor. All extracellular cysteines, Cys20, Cys103, Cys184, and Cys277, in the receptor were mutated to serines, and single and double mutants were transfected into COS-7 cells.
10 juni 2026 12:00 till 13:00 | Seminarium Topic: The Challenges of Generative AI for Democracy – Trust, Transparency, and Accountability in an AI-Infused Information LandscapeWhen: 10 June, 2026 12.00 to 13.00 CETWhere: Online - link by registration Speaker: Olof Sundin, Information Studies, Lund UniversityAbstractThis presentation examines the risks generative AI poses to democratic societies, f
Denna uppsats utforskar Protokoll till Konvention nr 29 (P029) och rekommendation nr 203 om tvångsarbete (R203). Syftet med denna uppsats är att svara på följande frågor, vad skiljer Protokollet och Rekommendationen från ILO Konventionerna om tvångsarbete i skrift och omfång samt vilken inverkan kommer Protokollet och Rekommendationen att ha internationellt, nationellt i Sverige och nationellt i TThis master thesis examines the Protocol of 2014 to the Forced Labour Convention, 1930 (P029) and the Recommendation on supplementary measures for the effective suppression of forced labour (R203). The objective of this thesis is to answer the following questions: what differentiates the Protocol and the Recommendation from the Conventions 29 and 105 in text and scope? And; what impact will the Pr
Genuine forms of participation of the local people are integral to the success of government development projects implemented to curtail escalating insurgency against the State in the restive southern borders provinces of Thailand. This thesis aims to determine the form of participation that has manifested itself and the mechanisms of power that shape its parameters, given the centralized and hier
Here you will find instructions on how to configure basic settings for your website. The settings you make here usually only need to be done once, for example when you set up a completely new website, but may also be relevant for you if you have taken over responsibility for an existing one. You can always go back and make changes if necessary. The settings you are given instructions for on this p
https://www.webbpublicering.lu.se/guides-english/basic-website-settings - 2026-07-21
Two sets of ribosome structures have recently led to two different interpretations of what limits the accuracy of codon translation by transfer RNAs. In this review, inspired by this intermezzo at the Ribosome Club, we briefly discuss accuracy amplification by energy driven proofreading and its implementation in genetic code translation. We further discuss general ways by which the monitoring base
The years 1988-1998 were named by World Council of Churches as The Ecumenical Decade - Churches in Solidarity with Women. On a worldwide scale, the Decade challenged member churches to portray Solidarity with Women in their contexts. Churches around the world launched a variety of projects and programs for this purpose. The Decade envisaged a new fellowship of women and men in church and society,
In this paper, the authors show that liquid-liquid partition chromatography in an aqueous two-phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen-antibody complexes are dependent on the variable regions of the antibodies, the nature o
Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to
På gående fot färdas man hastigt mellan kontinenterna. Venedigbiennalen är en plats där länder kan se världen och samtidigt synas för världen. Sedan 1895 har Biennalen samlat världens främsta konstnärer och arkitekter. Sverige delar en paviljong med Norge och Finland, vilket innebär konstnärliga kompromisser och att Sveriges enbart deltar var tredje biennal. Examensarbetet föreslår en svensk natiTraveling by foot, one swiftly moves between continents. The Venice Biennale is a place where countries can see the world and, at the same time, be seen by the world. Since 1895, the Biennale has brought together the world’s leading artists and architects. Sweden shares a pavilion with Norway and Finland, which means artistic compromises and Sweden’s participation only every third Biennale. The t
Combining a theoretical discussion of the inherent paradoxes in the celebration of new media technology as a source of democratisation and empowerment of civic cultures with an empirical focus aimed at the changing communicative manifests of mediated political protest, this paper analyses two cases of media strategies in protest movements: 1) A series of civil disobedience actions and mobilisation
A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on
