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UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We p
Den yttersta barriären mellan luften och blodomloppet i våra lungor består av en lipid-protein film. Denna lipid-protein blandning kallas för lungsurfaktant. Filmen bestående av lungsurfaktant stabiliserar alveolerna i våra lungor och gör att vi kan andas utan motstånd. Brist av lungsurfaktant kan orsaka svåra sjukdomar, till exempel hos förtidigt födda barn som ännu inte hunnit bilda tillräckligtThis thesis explores lipid self-assembly and aims to give a broad picture of self-assembly structures in simple and complex lipid-protein systems. The systems studied are lung surfactant, stratum corneum and simple model membranes. The lung surfactant mixture lines the alveolus in our lungs and stabilises the air- tissue interface. The lung surfactant lipid phase behaviour was here investigated wi
Objectives To investigate the impact of a multifactorial treatment programme in a real-life setting on clinical outcomes and estimated cardiovascular disease (CVD) risk. Design A retrospective observational cohort study, using data from the electronic medical records and national registers. Setting Tertiary diabetes centre in Denmark. Participants Patients with type 2 diabetes (n=4299) referred to
Background: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. T
Extracellular field potentials in the lumbosacral dorsal horn evoked by stimulation of cutaneous C fibres in the sural nerve were explored in the halothane‐anaesthetized rat. C‐fibre‐evoked field potentials were prominent in lamina II and lamina V of the dorsal horn. These potentials had a latency of 80‐130 ms and a duration of more than 200 ms. A peak in the C‐fibre‐evoked field potential, termed
Background: Fulminant myocarditis (FM) is a form of acute myocarditis characterized by severe left ventricular systolic dysfunction requiring inotropes and/or mechanical circulatory support. A single-center study found that a patient with FM had better outcomes than those with acute nonfulminant myocarditis (NFM) presenting with left ventricular systolic dysfunction, but otherwise hemodynamically
BACKGROUND: Impaired myocardial deformation has been sporadically described in cardiac asymptomatic systemic sclerosis (SSc). We aimed to study myocardial deformation indices in cardiac asymptomatic SSc patients using cardiac magnetic resonance feature tracking (CMR-FT) and correlate these findings to the phenotypic and autoimmune background.METHODS: Fifty-four cardiac asymptomatic SSc patients (4
OBJECTIVES: To evaluate the intra- and inter-rater agreement for myometrial lesions using Morphologic Uterus Sonographic Assessment terminology. METHODS: Thirteen raters with high (n = 6) or medium experience (n = 7) assessed 30 3-dimensional ultrasound clips with (n = 20) and without (n = 10) benign myometrial lesions. Myometrial lesions were reported as poorly or well defined and then systematic
Objective/background: Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic aortic aneurysms (MTAAs). Methods: Patients treated in Sweden for MTAAs between 2000 and 2016 were identified in the Swedish vascular registry (2010–16) and local patient registries (2000–09). Primary outcome was survival, and second
Migration patterns of Nordic Greylag Geese Anser anserwere studied by means of neck-collaring. A total of 4173birds (738 breeders, 1999 goslings and 1436 moulters;most moulters subsequently identified as belonging to aspecified breeding population) was marked throughoutNorway, Sweden, Denmark and Finland during 1984–1994. This report is based on observations made up to 30June 1995. In general, Nor
BACKGROUND: Workplace stressors, such as bullying, are strongly related to subsequent long-term sickness absence, but little is known of the possible physiological mechanisms linking workplace stressors and sickness absence. The primary aim of this study was to investigate to what extent cortisol levels were associated with subsequent sickness absence and if cortisol mediated the association betwe
BACKGROUND: It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association.METHODS: We studied the effect of ER-status of the first cancer on the risk of CBC overall, and for different ER-subtypes of CBC, using a large, popu
Objective: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Ostecarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement. Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Ost
Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc
Popular science summary: One of the greatest challenges in studying animal behavior is to understand it from the animal’s perspective. We will never know exactly how they look at or think about the world, but we can infer a lot from giving them signals and seeing their responses. In evolutionary biology, we are trying to find out what forces drove change in a specific direction. The “force” or s
Abstract Moraxella catarrhalis is a new pathogenic, gram negative bacterium that is the cause of many respiratory tract infections. MID was found to be a unique protein with Ig binding capacities. Moraxella catarrhalis immunoglobulin D (IgD)-binding protein (MID) is an outer membrane protein that has specific binding affinity to the soluble cell bound human IgD. A short fragment of MID comprised
Riksdagen har under hösten 2020 antagit de lagförslag som utarbetats i prop. 2019/20:190 Ekonomiskt arbetsgivarbegrepp – förändrade skatteregler vid tillfälligt arbete i Sverige. Den mest omtalade ändringen avser den s.k. 183-dagarsregeln i SINK och övergången från ett formellt till ett ekonomiskt arbetsgivarbegrepp. I propositionen presenterades det även lagförslag som numera innebär kraftigt ökaThe Swedish parliament adopted during the late autumn of 2020 the law proposals that were suggested by the Swedish government in prop. 2019/20:190 Ekonomiskt arbetsgivarbegrepp – förändrade skatteregler vid tillfälligt arbete i Sverige. The most debated topic has been the changes in the so called 183-day rule in SINK and the transition from a formal to an economic employer approach. In the same bi
Background: The widening socioeconomic gap in smoking during pregnancy remains a challenge to the Swedish antenatal care services. However, the influence of cultural factors in explaining the socioeconomic differences in smoking during pregnancy is not clear among the immigrant women. The aim of this study was to investigate whether the development of smoking prevalence among pregnant immigrant wo
OBJECTIVE: This systematic review aimed to assess the clinical outcomes of branched endovascular aneurysm repair (BEVAR) with inner branches (iBEVAR) and inner/outer branches (oBEVAR).DATA SOURCES: A systematic literature review was performed using the electronic bibliographic databases MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library up to May 2024.REVIEW METHODS: The review was
Background: The multifactorial nature of chronic pain should be reflected in pain assessment. The aim of this observational study comparing samples from three generations assessed at different times was to present differences in pain, stress and mental well-being. Methods: Pain sites, widespread pain, stress (Perceived Stress Scale-4) and mental well-being (30-item General Health Questionnaire) we
