Sökresultat

Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively fo

BACKGROUND: Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.METHODS: Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteom

Popular Abstract in Swedish Med ett stokastiskt fält (random field) kan man matematiskt modellera en yta vars struktur och variationer i större eller mindre utsträckning kan beskrivas som slumpmässiga. Ett typexempel är havsytan. Det finns vissa ''regler'' för hur den kan se ut, men det exakta utseendet hos en viss våg uppfattas som slumpmässigt. Reglerna omfattar bland annat medelnivån, huIn this thesis the focus is on crossing points in random fields and the probability distributions of various crossing variables in different applications. The crossing points are generalisations to random fields of points of level crossings by stochastic processes. Only crossing events that occur at distinct points in the parameter space are considered, for example stationary points (zero-crossing

OBJECTIVES: To investigate the effects on serum lipids, plasma fibrinogen, plasma insulin, plasma C-peptide and blood glucose, of smoking cessation after 4 months. To develop a group-based smoking intervention programme in primary health care. SETTING: Twenty health centres in primary health care in southern Sweden. SUBJECTS: Four hundred habitual smokers (> 10 cigarettes per day-1, > 10 years), r

This paper investigates the accuracy of three different methods that are used to perform a relative valuation. I also study the valuation accuracy of the three most widely used multiples used within these methods, the enterprise value to EBITDA (EV/EBITDA), the forward-looking price per share to earnings per share (P/EPS1), and the price-book (P/B). In addition, the difference between industries r

Background: Anterior cruciate ligament injury is a common knee injury and the treatment may be surgical and/or conservative. Different studies have shown surgical and conservative treatment, respectively, as the best intervention. Therefore it is uncertain which treatment is preferable. When searching in PubMed, no articles were found describing the thoughts and experiences of orthopedists and phy

Öresundsregionen är idag Nordens största transnationella samarbetsregion och omfattar hela Skånes län samt östra delen av Danmark. Sedan öppningen av Öresundsbron, år 2000, har regionen varit den arbetsmarknad som vuxit hastigast i Sverige och placerar sig betydligt högre upp än Stockholm på listan. Dock kan man inte se Öresundsregionen som en funktionellt integrerad enhet än. Ett närmare samarbetÖresund Region is, as of today, the biggest transnational region in Scandinavia. The inauguration of the Öresund Bridge in the year 2000 can be seen as the starting point of the regions rapid growth which has led to its surpassing of Stockholm in size. However, it has yet to fully function as an integral unit and a closer relationship between the economies is crucial for reaching a maximum of its

Den 2 juli 2014 infördes lagändringar om bygglovsbefriade åtgärder i syfte att förenkla plan- och bygglovsprocessen, minska bostadsbristen och att fastighetsägare skulle få mer handlingsutrymme utan att krav ställs från myndigheter. I samband med lagändringarna infördes regler om bygglovsbefriade komplementbostadshus i 9 kap. 4 a § PBL. En byggnad som får utgöra maximalt 25 kvadratmeter och som skThe Swedish Government has recently initiated additional permit-free buildings with the aim to simplify the Planning and Building act, reduce the housing shortage and increase a property owner’s proprietorship. According to the amendment it is possible to construct a complementary home with the size of 25 square meters in close proximity to an existing house. This building is known as an Attefall

Godssektorn spås bli en tidig användare av självkörande fordonsteknik. Minskade drivmedelskostnader, ökad flexibilitet i ruttplaneringen och utökade drifttider är exempel på incitament för godsföretag att ställa om till en självkörande lastbilsflotta. Automatiseringen kommer mest sannolikt ske gradvis. I tidiga skeden spås självkörande lastbilar (AT:s) ha en konservativ körstil där körfältsbyten uThe truck sector is thought to be one of the first adopters of autonomous driving technology. Reduced fuel- and labour costs, increased flexibility in scheduling and increased hours of service, are all incentives for the freight companies to go autonomous. The automation of the truck fleet is likely to be gradual. At first, autonomous trucks (AT:s) are expected to have a conservative driving style

I Sverige har efterlevandeskyddet för sambor varit en omdebatterad fråga under de senaste decennierna. Inte minst aktualiserades frågan till följd av tvisten som uppstod efter författaren Stieg Larssons bortgång. Trots utredningar och medial uppmärksamhet har det emellertid inte skett några förändringar i den svenska rätten. Samtidigt har det i både Danmark och Norge, två grannländer med i övrigt In Sweden there has been a longstanding debate in regards to the legal provisions for surviving cohabitants. The question gained attention in particular after the sudden passing of the famous swedish author, Stieg Larsson, and the following legal dispute. In spite of the public attention and public enquiries no significant changes to the Swedish legislation has been undertaken. In the meanwhile bo

Sweden has a significant rental sector with about a third of the total number of households rented out. The intention of the rental market should be that it is accessible to all people in society, regardless of nationality or income. The general mediation of rental apartments today is through a queuing system, which in Stockholm shows that a queuing time can be up to half one's life. The alter

This paper reviews the literature on R&D and productivity to provide a guideline to readers by combining all the findings in one title. According to the results, empirical studies analyse R&D spending from different angles by considering the characteristic of such spending. The results show that return to basic research is higher than return to applied R&D. Furthermore, in order to est

Det finns ingen offentligrättsligt reglerad möjlighet att tvångsadoptera ett familjehemsplacerat barn i Sverige. Den mest ingripande åtgärden som offentliga myndigheter och organ kan vidta inom ramen för lag (1990:52) med särskilda bestämmelser om vård av unga är en vårdnadsöverflyttning från barnets biologiska föräldrar till familjehemsföräldrarna. I fråga om tvångsvård av barn är den civilrättslThere is no legal possibility to forcibly adopt a child who has been placed in a foster home in accordance with public law in Sweden. The most intru-sive measure that public authorities can take within the framework of The Care of Young Persons Act is a transfer of legal custody from the child's biological parents to the foster parents. The civil law regulation in the Pa-rental Code is intende

Sverige ämnar bygga sina höghastighetsbanor som beräknas vara i drift 2035. Höghastighetsnätet löser kapacitetsproblemet i framtiden, Sveriges miljö-och klimatmål kräver mer järnväg och höghastighetsnätet kan öka tillgängligheten till möjliga arbeten inom 45 min restid (SJ u.å.). Många orter som ligger i närheten av den förslagna höghastighetsbanan önskar att ingå i höghastighetsnätet. De höga inSweden intends to build its high-speed railways, which are expected to be operational by 2035. The high-speed network solves the capacity problem in the future. Sweden's environmental and climate goals require more rail and the high-speed network can increase access to possible jobs within 45 minutes of travel time (SJ u.å.). Many cities that are close to the proposed high-speed railway wish

Purpose: The purpose of this research was to investigate how outdoor textile brands align their brand bdentity with their management actions and communication to become more circular. It was as a consequence explored how communication strategies of outdoor brands align with their management decision and how management actions push the transition of a brand towards more circularity. Methodology: Th

The aim of this project was to investigate suitable prototyping methods to be used during the development of horn loudspeakers. Different methods were tested to investigate how well they replicated the original loudspeaker based on acoustical performance. The methods were also evaluated based on other requirements such as cost, manufacturing process and ability to handle complexes shapes. The meth

Land use for reindeer husbandry and forestry are overlapping in large areas of northern Sweden. This co-location is characterized by dynamics in which the forest industry owns the land and the power to transform it, and the reindeer industry possesses a user-right for reindeer grazing and herding. During the last couple of years, critique towards the forest industry has grown louder, and reindeer-

Titel: Att träna eller inte träna - en enkätstudie över en grupp kvinnors träningsvanor och besvär före och under graviditet Bakgrund: Under en graviditet drabbas många kvinnor av olika besvär och komplikationer, exempelvis ländryggs- och bäckensmärta, graviditetsdiabetes, illamående och havandeskapsförgiftning. Genom träning kan man minska risken för att utveckla dessa besvär men även uppnå flera

I denna uppsats undersöks vad det innebär att en vara säljs med ett förbehåll såsom befintligt skick, särskilt utifrån 19 § köplagen. Uppsatsen tar sikte på de rekvisit som återfinns i det första stycket 19 § köplagen, och ämnar utröna när en vara kan anses felaktig trots att den sålts med ett förbehåll så som exempelvis befintligt skick. I det första stycket i 19 § köplagen återfinns tre punkter This essay examines what it means when a product is sold in its existing condition, especially based on 19 § the sale of goods act. The essay aims at the requisites found in the first paragraph of 19 § the sale of goods act and aims to find out when a product can be considered faulty even though it was sold with a reservation such as, “as is”. In the first paragraph of 19 § the sale of goods act,