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Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or

Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good

Objective To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcriptionpolymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients with SLE,

Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri

A sudden unilateral loss or impairment of vestibular function causes vertigo, dizziness and impaired postural function. In most occasions, everyday activities supported or not by vestibular rehabilitation programs will promote compensation and the symptoms subside. As the compensatory process requires sensory input, matching performed motor activity, both motor learning of exercises and matching t

Popular Abstract in Swedish För drygt ett decennium sedan beslutade EU:s dåvarande tolv medlemsstater att upprätta ett gemensamt europeiskt medborgarskap för unionens invånare. Alltsedan dess har det europeiska medborgarskapet varit en omdiskuterad och kontroversiell, men för den breda allmänheten tämligen okänd, innovation i den europeiska integrationen. I Medborgarskap efter nationalstaten ? ettThis thesis is an attempt to formulate a constructive proposal for the ongoing establishment of a post-national European citizenship in the European Union. To the extent that the proposal is post-national, the ambition is to re-conceptualise the idea and ideal of citizenship in a new historical setting. To the extent that the proposal is constructive, the ambition is to develop and employ a method

Popular Abstract in Swedish Ett nytt EU-direktiv om uttjänta fordon har nyligen antagits. Direktivet kräver att från och med 2006 skall 85% av bilens vikt återvinnas och 95% från och med år 2015. Idag återvinns cirka 80%. Bildemonteringsindustrin har valts som studieobjekt i denna avhandling. De höjda återvinningskraven förväntas leda till att bildemonteringsindustrin genomgår omfattande rationaliA new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. The current level is about 80%. The car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry may undergo comprehensive rationalizations a

Background: Non-linearities in observed log-ratios of gene expressions, also known as intensity dependent log-ratios, can often be accounted for by global biases in the two channels being compared. Any step in a microarray process may introduce such offsets and in this article we study the biases introduced by the microarray scanner and the image analysis software. Results: By scanning the same sp

OBJECTIVES: Sleep deprivation has experimentally been shown to adversely influence glucose metabolism, endocrine function and sympathovagal balance in young men without known serious disease. We investigated the impact of sleep problems and resting heart rate in a large sample of self-reported, healthy middle-aged men and women on long-term mortality. METHODS: In all 22,444 men and 10,902 women pa

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated cells. Overexpression of EZH2 has been found in several cancer types such as breast, prostate, melano

Liberalisation and deregulation of public utility sectors has been introduced in several European countries. In 1994 Swedish municipalities were instructed to reorganise waste collection routines by enlarging the number of fractions to be able to reuse waste fractions in an environmental benign way. The public waste sector have to a considerable extent been diversified and deregulated. At the same

Popular Abstract in English Plants harvest sunlight to fix air carbon dioxide into a form which is the fundamental source of energy for other organisms such as animals. The domestication of crop plants and traditional breeding practices has resulted in increased yield and nutritional value of crops. This comes at a cost of loss in genetic variability that is required by living organisms to adapt tPotato is one of the major food crops and its yield is severely affected by late blight disease caused by Phytophthora infestans. P. infestans has the ability to manipulate plant defence signalling by secreting effector molecules causing so called effector triggered susceptibility. Some plants can recognize these effectors via resistance proteins that reactivate plant defence and lead to effector

Popular Abstract in Swedish Mesenteriell ischemi (nedsatt blodcirkulation till tarm och övriga bukorgan) är vanligt förekommande vid ett flertal olika sjukdomstillstånd som t ex blödnings-, septisk och cirkulatorisk chock. Inte minst är tarmen mycket känslig för nedsättning av blodflödet. Tarmskadan, inkluderande dess barriär(skydds-)funktion sker dels under perioden med nedsatt blodförsörjning meIntestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction

A systematic study of cell membrane morphologies whose structure is governed by cubic symmetries has been performed. It is suggested that they are described by periodic cubic surfaces for which space filling surface foliations given by truncated Fourier series defined by the space groups is used as structural representations. Using this a method is developed which enables a direct ultrastructural

Popular Abstract in Swedish Polymergeler och deras interaktioner med joniska surfaktanter. Olika typer av hydrofoba polymerer och hydrophobmodifierade polymerer tvärbinds kemisk till geler. Dessa geler tillhör gruppen responsiva geler, vilket betyder att gelerna ändrar sin volym under yttre påverkan. Gelernas volymändring studeras vid tillsats av olika joniska surfaktanter, vid tillsats av saltThe response on chemically crosslinked gels and polymer solutions on the addition of ionic surfactants and/or addition of salt at different temperatures have been studied. All polymers studied are water soluble and slightly hydrophobic or hydrophobically modified. Because of their hydrophobicity the polymers have a strong tendency to associate, both with themselves and with surfactants. Another i

Two separate topics in the area of colloidal chemistry have been investigated by the use of molecular modeling: the structural properties of polyion?macroion complexes and of diblock polyampholyte brushes. The main results were obtained by the use of Monte Carlo simulation in the framework of the primitive model, and in the case of polyampholyte brushes the simulation results were also complemente

The fracture process of a laminate is analysed. The laminate is a material used for packaging.It consists of a thin aluminium foil with a polymer coating. In both materials, the fractureprocesses are supposed to be dominantly localized plastic deformation. A Barenblatt regionis supposed to spread ahead of the crack tip. This region is analysed in its cross planeinvoking plane deformation conditionThe fracture process of a laminate is analysed. The laminate is a material used for packaging.It consists of a thin aluminium foil with a polymer coating. In both materials, the fractureprocesses are supposed to be dominantly localized plastic deformation. A Barenblatt regionis supposed to spread ahead of the crack tip. This region is analysed in its cross planeinvoking plane deformation condition

BACKGROUND: Of all patients with low back pain, 85% are diagnosed as "non-specific lumbar pain". Lumbar instability has been described as one specific diagnosis which several authors have described as delayed muscular responses, impaired postural control as well as impaired muscular coordination among these patients. This has mostly been measured and evaluated in a laboratory setting. There are fe

As part of the LBA-SMOCC (Large-Scale Biosphere-Atmosphere Experiment in Amazonia – Smoke, Aerosols, Clouds, Rainfall, and Climate) 2002 campaign, we studied the emission of carbon monoxide (CO), carbon dioxide (CO2), and aerosol particles from Amazonian deforestation fires using an instrumented aircraft. Emission ratios for aerosol number (CN) relative to CO (ERCN/CO) fell in the range 14–32 cm−3