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Background: Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, race in eGFR equations is a social and not a biologic construct.Methods: We developed new eGFR equations without race using data from two development data sets: 10 studies (8254 participants, 31.5% Black) for serum c

BACKGROUND: Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and safety of selepressin, a novel V1A-selective vasopressin analogue, was examined in a phase IIa trial in septic shock patients.METHODS: This was a randomized, double-blind, pla

Background: The desire to be a mother is much more than a reproductive instinct in pro-baby (pro-natal) society. Motherhood is a complex phenomenon that encompasses psychological, social, and cultural aspects of a woman's holisticwell-being. A woman's socio-cultural visibility is enhanced through motherhood, which also strengthens her psychological status, enriches her spiritual experience, and en

Smooth muscle cells (SMCs) are constituents of hollow inner organs. Their contractile function governs essential physiological functions, such as breathing, eating, blood pressure control, urination, and childbirth. Skeletal and cardiac muscle cells are terminally differentiated cell types, but SMCs are highly plastic and change their phenotype in disease. Cues presented by the microenvironment an

Aims/hypothesis: Low birthweight (LBW) is associated with younger age, less obesity and more hypertension among people recently diagnosed with type 2 diabetes, as well as increased cardiovascular morbidity and mortality risk. It is not known whether LBW is associated with an increased risk of incident chronic kidney disease (CKD) among people with a type 2 diabetes diagnosis. Methods: Original mid

Svensk pantlagstiftning har under lång tid i princip varit oförändrad. Några för panträtten centrala bestämmelser har över tiden hjälpligt fått anpassats till mer tidsenliga förutsättningar som de ursprungliga bestämmelserna inte varit utformade att hantera. Detta gäller inte bara tillämpningen av panträttslig lagstiftning utan även de rättsliga principer som omgärdar panträtten och fyller där en Swedish law regarding pledges has more or less remained the same for a substantial period of time. Some of the central principles concerning pledges have over time needed to adapt to more modern situations that the law are not designed to handle. This does not only concern the application of the written laws but also the legal principles that surround the law on pledges where they aim to serve a c

Popular science summary: New approaches for treating lakes with ammonia pollution Extract of Yucca shidigera, a desert plant, has been used in aquaculture to control ammonia in the water. Microalgae has been proved effective in removing ammonia and phosphorous from wastewater of agriculture and aquaculture. Therefore, it is possible that they could remove ammonia from lakes. Hence, several fish t

Sammanfattning Den kanske största miljöpolitiska utmaningen inom Europa är för närvarande frågan om hur det är möjligt att på ett effektivt och ändamålsenligt sätt uppnå miljömålen i syfte att skapa en hållbar utveckling i samhället. Trenden har gått från att tillgripa lagstiftningsåtgärder till att via marknadsbaserade styrmedel försöka involvera olika marknadsaktörer att på egen hand bli delaktSummary Potentially one of the greatest environmental policy challenges in the European Union is the question of how to efficiently and effectively achieve environmental goals through which society can correct for and obtain a level of sustainable development. The trend has gone from one of command and control legislation towards using more market-based instruments that seek to involve the differ

Hårdmetall är kompositmaterial av hårda volframkarbidkristaller i en seg koboltmatris. Det är ett användbart material, framförallt inom skärande bearbetning så som fräsning, borrning och svarvning, pga att segheten från kobolten kombineras med hårdheten från volframkarbiden. Man kan relatera hårdheten och segheten i hårdmetallen till dess mikrostruktur, där små karbidkristaller ger ett hårdare matThe grain growth of WC in WC-7%Co cemented carbides with Cr-addition was investigated for cemented carbides synthesized from four different raw materials varying in grain size. Cr additions were 4%of the Co binder phase. To investigate the effect of Cr on grain growth two of the raw materials were also synthesized without Cr-additions. To investigate the effect of cobalt content on grain growth ce

En betydande del av alla offentliga upphandlingar leder till upprättandet av ramavtal. Denna avtalsform anses vara att föredra vid tillfällen då den upphandlande myndigheten har svårighet att på förhand avgöra vilken volym som kommer behövas, vid vilken tidpunkt leveransen ska ske samt vid osäkerhet kring den exakta utformningen av kontraktsföremålet. 2014 godkände Europaparlamentet tre nya direkA considerable part of all public procurements leads to the establishment of a framework agreement. This form of agreement is considered to be preferable at times when the contracting authority has difficulty to determine the volume that will be needed, at which point delivery is to take place and in the case of uncertainty about the exact framing of the subject- matter of the contract. In 2014,

De svenska reglerna om principalansvar trädde i kraft 1972, när en ny skadeståndslag antogs av Riksdagen. Innan denna tidpunkt hade regler om principalansvar utvecklats i rättspraxis, men omfattningen av detta ansvar hade varit väldigt begränsad. I de flesta fall hade en arbetsgivare inte kunnat hållas ansvarig för de skador som hans anställda vållat i tjänsten. När regler om principalansvar intoThe Swedish regulation of vicarious liability entered into force in 1972, when a new Liability for Damages Act was passed by the parliament. Prior to this point in time, a concept of vicarious liability had developed in Swedish case law, but the scope of such liability had been very limited. In most cases, an employer would not have been held responsible for tortious acts caused by his employees i

Förevarande uppsats behandlar de argument och ställningstaganden som ligger bakom lagstiftarens beslut beträffande assisterad befruktning i allmänhet, och surrogatmoderskap i synnerhet. Den alternativa familjebildningen och den assisterade befruktningens historia går långt tillbaka i tiden, men började på allvar regleras på 1980-talet, då inseminationsutredningen grundligt utredde frågan. VariatThe thesis at hand deals with the arguments and positions underlying the legislators decisions concerning Assisted Reproductive Technology (ART) in general, and surrogate motherhood in particular. The history of alternative ways to start a family, and ART goes far back. However, it only really began to be the subject of regulation in the 1980s, when the government issued an investigation, to thoro

Over the last 40 years, the concept of resilience has made a journey from the fields of ecology and psychology into the social sciences. By now, it has become a term commonly used in the international climate change adaptation and development spheres, describing the ability of an individual or a community to cope with or recover from harmful events. Critics have raised concerns about this spread,

More than 70% of the population in Ethiopia lack access to electricity and thus rely on traditional sources of energy such as biomass that is associated with negative consequences on health and the environment. Decentralized community-based micro-hydropower plants (MHPs) are being utilized as effective means to transition to modern low-carbon energy systems providing access to electricity to commu

En ny anställningsform som växt fram i digitaliseringens fotspår är arbete som utförs via digitala plattformar. Plattformsarbete är en del av en större pågående strukturell förändring, nämligen flexibiliseringen av arbetsmarknaden. Denna strukturella förändring gör att den nuvarande gränsen mellan arbetstagare och uppdragstagare suddas ut. Begreppet arbetstagare anger gränserna för arbetslagstiftnWork supplied through digital platforms is a new form of employment that has emerged in the course of digitalization. Platform work is part of a bigger ongoing structural shift, namely the flexibilisation of working life. This structural shift blurs out the distinction between an employee and a self-employed worker. The personal scope of Swedish labor law is defined by use of the notion of employe

Grundämnena, som bygger upp komplexa molekyler som vårt DNA, är samma material som stjärnor består av. Faktum är att vi människor består till 93 % av så kallat sjärnstoft, eller sjärndamm. De simplaste ämnena, väte och helium, skapades i Big Bang, för ungefär 13,7 miljarder år sedan. De resterande 90 ämnena i periodiska systemet bildas i olika typer av stjärnor och i detta arbete har jag tagit fraPurpose: The purpose of this work is to determine the abundances of neutron-capture elements in solar neighborhood giant stars. This enables constraints to be put on the the cosmic origin of these elements. I have determined abundances of elements produced in both the weak s-process (Cu), the first and second s-process peaks (Y, Zr and La, Ce, Pr, Nd, respectively) and the r-process (Eu, Gd). The

The Swedish national library has collected nearly all Swedish printed materials for more than three centuries. Regarding digital material, the digital legal deposit act was enacted about nine years ago. According to the law, a selection of digital publications must be sent to the national library for preservation. The Swedish digital legal deposit act has been heavily criticized, mostly because it

The phenomenon of global warming has become a fact, however; the uncertainty is about the magnitude and acceleration of its manifestations. Global mean sea level rise is one of the results induced by global warming and is happening with an undetectable accelerated pace. The world international organizations and governments are devoting efforts and initiatives in a trial to manage global warming in

This thesis consists of an initial environmental investigation of the Sparbanken Öresund. The Bank currently has an environmental policy and ambitions from 2011 but no one has been responsible for implementation of them. In addition, upon my review of the policy and ambition list I found that there were neither measurable objectives nor procedures for how those objectives will be met, thereby crea