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Fractionation gives therapeutic benefit in animal model of [177Lu]Lu-PSMA-617 therapy of prostate cancer

BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved

Similar support for three different life course socioeconomic models on predicting premature cardiovascular mortality and all-cause mortality

Background: There are at least three broad conceptual models for the impact of the social environment on adult disease: the critical period, social mobility, and cumulative life course models. Several studies have shown an association between each of these models and mortality. However, few studies have investigated the importance of the different models within the same setting and none has been p

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Abstract in French Au-delà du montage – la rhétorique du cinéma Contrairement à d'autres types d'images plus statiques, le film, avec son fort "effet de réalité", semble résister à une explication inspirée d'un modèle rhétorique. Même du point de vue d'une rhétorique "écologique", telle que la nôtre, qui reconnaît une rupture de normes déjà dans les transformations homogènes, le film peut facilem

Enzymatic synthesis of lipids containing omega-3 fatty acids

Popular Abstract in Swedish Dokosahexaensyra (DHA) och eikosapentaensyra (EPA) är omega-3 fettsyror, som har hälsofrämjande effekter. De behöver skyddas, DHA i synnerhet, eftersom de är mycket känsliga för oxidation. Flera lipider som innehöll DHA utvärderades med avseende på lipidernas möjlighet att skydda DHA mot peroxidation genom att använda en HPLC metod som utvecklades som en del av detta arDocosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids, which have health promoting effects. Since they are highly prone to oxidation, they should be protected, in particular DHA. Several lipids containing DHA were evaluated with respect to the ability of the lipids to protect DHA against peroxidation using an HPLC method developed as part of this research. Furthermore,

Vinn mot svinn - En studie som belyser hur producenter kan hjälpa konsumenter att minska sitt omfattande matsvinn

Var tredje inhandlad matkasse slängs, vilket innebär att en tredjedel av all mat har producerats helt i onödan. Detta motsvarar 1,3 miljarder ton varje år - vilket uppskattas kunna mätta tre miljarder hungriga magar. För att uppnå hållbar konsumtion behöver matsvinnet halveras inom tio år. Livsmedelsproduktion skapar utsläpp av växthusgaser, luftföroreningar och bekämpningsmedel som påverkar både Nature has provided us with delicious and nutritious food for many years. It is estimated that one third of all edible food is wasted globally. This means a substantial loss of resources. Consumers are unaware of the great amount of avoidable food waste that is created from household consumption and the environmental impact it has. It is of great importance to increase consumer awareness to reduce

Övervikt hos romerska kvinnor - synen på övervikt i antik och modern medicin

This essay is written because I would like to find out what the doctors in ancient Rome thought about overweight women. The reason why it is written is due to the fact that modern medicine associates many diseases with overweight, and because I myself happen to be overweight. I will do a comparison between modern medicine and the ancient medical writers to see if they did associate overweight with

Legalisering av det egna bruket av narkotika - följder för polisens praktiska arbete ur ett tvångsmedelsperspektiv

Föreställ er att vi i Sverige skulle legalisera det egna bruket av narkotika. Det skulle bli lagligt att snorta kokain, att skjuta upp heroin eller att röka marijuana. Vad skulle detta innebära för svensk Polis, sett ur ett tvångsmedelsperspektiv? Toleransen i Sverige gentemot droger är väldigt låg. Narkotikafrågan har under en längre tid varit, och är fortfarande, högprioriterad hos regering ochImagine that we, in Sweden, would legalise the personal use of drugs. It would be legal to snort cocaine, to shoot up some heroine or smoke marijuana. What would this mean for the Swedish law enforcement, from a "means of enforcement" point of view? The Swedish tolerance when it comes to drugs is very low. It has for a long time been, and still remains, a top priority for the governmen

Stuck in the door? A study of temporary agency work as an entry point to the labor market

This thesis is a critical examination of the notion of an entry point to the labor market through a temporary work agency. By exploring the experience, content and consequences of temporary agency work I have investigated how power relations within the contemporary work life are articulated. Temporary agency work is portrayed as a labor market entry point for groups in risk of exclusion, such as i

Moisture Induced Stresses and Deformations in Parquet Floors - an Experimental and Numerical Study

The indoor climate conditions in buildings have changed in the last decade due to more efficient climatic systems, floor heating systems and larger open floor areas with more natural light. These factors all give increased annual variations in the humidity and the temperature in parquet floors. Such variations can result in troublesome deformations, glue line delamination and development of cracks

Avtalsregleringar på ABL:s område - särskilt om avståenden från rättigheter enligt överlåtelsebegränsningar i bolagsordningen

I svensk aktiebolagsrätt finns en grundläggande princip om att aktier fritt ska kunna överlåtas mellan olika rättssubjekt. Trots att principen får anses vara skyddsvärd har lagstiftaren stadgat tre undantag från principen: hembud, förköp och samtycke. Undantagen – kallade överlåtelsebegränsningar – kan införas i bolagsordningen och utgör i praktiken kontrollprocesser genom vilka befintliga aktieägAn essential principle in the Swedish company law is the principle of free transferability of shares. The signification of the principle is to ensure the free transfer of shares between different legal entities. Despite the fundamental nature of the principle, the lawmaker has granted three exceptions to the principle: a post-sale purchase right clause, a right of first refusal clause and a conten

Enhancement of innovation in the public sector: a qualitative study of how Swedish municipalities have worked with innovation hubs to meet global and social challenges

The purpose of this study is to explore the enhancement of innovation in the public sector when municipalities use innovation hubs to meet global and social challenges. The study is aimed at examining the process of how the hubs implement innovation. This research contributes to the Swedish research of innovation and provides knowledge to managers about beneficial methods regarding managing change

Can the general reverse charge mechanism combat missing trader fraud and provide for secure VAT collection?

This thesis explores the European Commission’s proposal on General Reverse Charge Mechanism. VAT is a final tax on consumption. It is imposed on every transaction in the supply chain with the general aim of being deductible and thus being neutral for businesses with the right to deduct. The initial aim of the VAT system was to operate as if all the transactions occurred in one single country; howe

The role of CTCF and cohesin in high hyperdiploid childhood acute lymphoblastic leukemia

Chromosome defects in high hyperdiploid childhood acute lymphoblastic leukemia Acute lymphoblastic leukemia (ALL) is a type of blood cancer that affects both adults and children. While human cells normally harbor 46 chromosomes, the leukemic cells of the high hyperdiploid subgroup (HeH) of childhood ALL presents 51-67 chromosomes, where the extra chromosomes are generally X, 4, 6, 10, 14, 17, 18

EU-, Konkurrensrätten och Svensk Idrottsrörelse

Sammanfattning: EU-, Konkurrensrätten och Svensk Idrottsrörelse Idrottens och särskilt fotbollens popularitet och idrottsrörelsens ideella / icke-vinstdrivande förhållanden, idrottens särart, genererade stora samhällsvärden under 1900-talet och lämnades med marginell svensk rättsinblandning. Istället kom fotbollsföreningar och utövare att underordnas förbundsmonopol från 1904 med strikt [regel]hieAbstract: EU-law, the rules on Competition and movement of Sport The popularity of athletics and particular football and the non-profit circumstances of movement of sport, generated great additional value to society and was therefore almost left without intervention from Swedish public law-system during the 20th century. Instead, since 1904, all Swedish football clubs and players are forced to fol

Vattensänkningar : en analys av orsaker och effekter

Populärvetenskaplig sammanfattning: Grässjön ligger på kommungränsen mellan Osby och Östra Göinge, och har varit utsatt för stora förändringar på 18- och 1900-talen, bl. a. sänkningsprojekt och ändrade flöden. Sjön ingår i Tommaboda/Ekeshultsån, som är en del av Skräbeåns avrinningssystem - en av de åar som rinner ut i Hanöbukten. Grässjön var före 1909 en del av den tills då mycket större VielånThere are records of lowering of the water level in a lot of the Swedish lakes from the middle of the 1700th century. The aim was gaining more areable land to meet the needs of more food to support the expanding population. In areas with top soil which contents of clay or loam as in the southwest of Scania in southern Sweden this was proven to be a successful way expanding the total outcome of the

Museipedagogik på Statens Museum for Kunst : En undersökning om utveckling av sätt att se och förstå konstverk

Uppsatsen tar upp museipedagogik på Statens Museum for Kunst i Köpenhamn. Eftersom det är ett konstmuseum handlar pedagogiken om konstpedagogik men också om pedagogik som står i relation till skolan. De pedagoger som tas upp är de som varit speciellt inflytelserika för 1900-talets skola och undervisning. Pedagoger som Piaget, Vygotskij, Dewey och Klafki nämns såsom förebilder även till museipedago

Development of an ELISA to accurately measure the solubility of the amyloid beta 42 molecule

Amyloid beta (Aβ) proteins are a group of proteins able to form fibrillar aggregates that are linked to the adverse neurological effects seen in Alzheimer’s disease [11]. The molecular mechanisms that lead to the Aβ aggregation are complex processes, and efforts to understand them are being made by investigating the kinetics and thermodynamic properties of the protein. The solubility of the protei

Investigation of Fermentation as a Processing Technique for HPP-treated Oat Okara and Its Potential Application in Food products

Introduction: Side-stream residue, oat okara, from the oat-milk production contains valuable nutrients but possesses a high risk of microbial spoilage. Valorisation of oat okara is therefore important to make sure that the oat beverage production stays sustainable. In this project, High-pressure processing (HPP), heat treatment and Lactobacillus fermentation have been evaluated for their microbial

Lipid bilayers versus monolayers- Sponge phases and skin lipid domains

The L3, or sponge, phase is a thermodynamically stable isotropic liquid consisting of a surfactant membrane in aqueous solution. A solvent induced L3 phase is shown in systems of solvent, monoolein and water. Dimethyl sulfoxide, propylene glycol, polyethylene glycol, ethanol, N-methyl-alfa-pyrrolidone and 2-methyl-2,4-pentanediol are solvents of varying hydrophilicity but are all miscible with bot

The Balance between Fundamental Freedoms and Fundamental Rights in the European Community

Fundamental rights and the four fundamental freedoms co-exist in Community law. These two fundamental interests have been placed on the highest normative level by the ECJ. Notwithstanding its similarities, fundamental rights and fundamental freedoms are two different notions, where the former is typically human rights and the latter applies primarily to economic circumstances. When these two funda