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Chaperones protect other proteins against misfolding and aggregation, a key requirement for maintaining biological function. Experimental observations of changes in solubility of amyloid proteins in the presence of certain chaperones are discussed here in terms of thermodynamic driving forces. We outline how chaperones can enhance amyloid solubility through the formation of heteromolecular aggrega
Reduced ventricular longitudinal shortening measured by atrioventricular plane displacement (AVPD) and global longitudinal strain (GLS) are prognostic markers in heart disease. This study aims to determine if AVPD and GLS with cardiovascular magnetic resonance (CMR) are independent predictors of cardiovascular (CV) and all-cause death also in heart failure with reduced ejection fraction (HFrEF). P
BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in r
Twelve commercially available triacylglycerol lipase preparations were screened for their suitability as catalysts in the interesterification of palm oil mid fraction and ethyl stearate to form a cocoa butter equivalent. Five fungal lipase preparations were found to be suitable. The hydrolytic activity of the commercial lipase preparations was tested with sunflower seed oil and was independent of
OBJECTIVES: Alcohol use disorders (AUD) is well known to aggregate in families and is associated with socioeconomic status (SES). The objective was to study the effect of education, income and neighborhood SES in adulthood on AUD, and to explore whether the potential associations were confounded by shared familial factors, by using a co-relative control design. METHODS: Data on AUD was drawn from
The circulation is a closed system that has been assumed to be free from bacteria, but evidence for the existence of a low-density blood microbiota is accumulating. The present study aimed to map the blood microbiota of outpatients with Crohn’s disease (CD) or with ulcerative colitis (UC) by 16S metagenomics. A diverse microbiota was observed in the blood samples. Regardless of the type of disease
Efficient and timely maintenance is essential for the robust operation of infrastructure across all types of transport. In the railway sector, track maintenance presents unique challenges. Specifically, some maintenance tasks require track closures, which can disrupt train schedules. Coordinating these closures with regular train operations makes the scheduling process complicated. To ensure suffi
BackgroundDuring recent years FLASH radiotherapy (FLASH-RT) has shown promising results in radiation oncology, with the potential to spare normal tissue while maintaining the antitumor effects. The high speed of the FLASH-RT delivery increases the need for fast and precise motion monitoring to avoid underdosing the target. Surface guided radiotherapy (SGRT) uses surface imaging (SI) to render a 3D
In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive function, fatigue, sleep disturbance, anxiety, depression, pain interference
Inflammation and insulin resistance are associated with increased mortality in the general population. However, it remains unclear how physical activity and proinflammatory/hyperinsulinemic diets influence overall survival in prostate cancer patients. We analyzed 4779 men with nonmetastatic prostate cancer from the Health Professionals Follow-up Study. Postdiagnosis physical activity and diet were
Huvudregeln i upphandlingsrätt är att upphandlingar ska annonseras. Detta grundar sig i principerna om att upphandlingar ska vara öppna för alla leverantörer att söka för att principerna om fri konkurrens och fri rörlighet av varor och tjänster i den inre marknaden ska säkerställas. Emellertid finns det undantag från denna huvudregel. Vid synnerlig brådska finns det möjlighet att frångå annonserin
Statistical modelling could be included in a betting strategy where the value of a bet is assessed by comparing model predictions and market odds. This thesis presents several models based on statistical learning methods for predicting the total number of corners in a football match. Generalised linear regression and decision tree models were developed and their profitability was examined by using
WUI-NITY is a computer modelling program for wildfire evacuation simulations. This thesis examines the applicability of WUI-NITY to locations in Sweden. The program was tested at example locations representing the Swedish landscape. The objective of this work was both to examine the application of the model, but also to produce a process by which the model might be applied – highlighting challenge
In a digital age where travellers are increasingly looking for the cheapest, fastest or most sustainable way to travel, comparing different modes of transport efficiently becomes a challenge. The internet offers a wide range of websites and travel providers, fragmenting information and forcing travellers to navigate inefficiently between different platforms and websites. Multimodal Digital Mobili
In this master's thesis I will study library space in its practical use in relation to the professionals working in it daily, i.e. the library staff. It seems that this profession should have a unique knowledge base around how the library is used and how space can be organised to benefit the users, the staff and the collections. The library is closely connected to and affected by society and s
This report has been conducted to examine the advantages and disadvantages of using an open system for experiments in the cone calorimeter with a vitiated air enclosure at low oxygen levels. Eight different experimental set-ups were conducted in which two were designed according to ISO 5660, i.e. the cone calorimeter in its standard configuration. In the other experimental set-ups, a chamber which
Internet of Things (IoT) is a network constituted by uniquely identifiable commodity objects or devices equipped with some sensing system. To achieve high data rates required for IoT devices, a modern wireless communication system, known as Advanced Antenna Systems(AAS), leads to significant improvement, by increasing not only the data rate but also spectrum efficiency and the channel capacity. A Internet of Things (IoT) is network constituted by day-to-day objects equipped with some sensing system. These objects can also communicate with other objects for data exchange, wirelessly. This calls for a need of better wireless communication systems. New techniques using the 4G (Long-Term Evolution) have been developed to solve this problem, known as Advanced Antenna System (AAS). This new tech
Abstract This master thesis investigates how more value can be created by digitally visualize the saved data of GGzE (Mental Health care Eindhoven). GGzE collects a lot of data about their clients and they believe that more value can be created from it. The Dutch government, as well as the European commission, is striving for more e-health. By 2019 the Dutch government wants 80% of the ch
