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A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses tip to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period.

BACKGROUND: In this study we have taken an interest in systemic exposure to nickel in patients with delayed hypersensitivity to nickel. OBJECTIVE: The aim of the study was to more closely investigate the importance of factors such as ingested nickel dose, time interval between nickel patch testing and oral nickel challenge as well as degree of nickel hypersensitivity in relation to flare-up reacti

Cystinuria is an autosomal recessive disorder characterized by increased urinary excretion of cystine and dibasic amino acids, which cause recurrent stone formation in affected individuals. Three subtypes of cystinuria have been described (type I, II, and III): type I is caused by mutations in the SLC3A1 gene, whereas nontype I (II and III) has been associated with SLC7A9 mutations. Of the 53 pati

BACKGROUND: The metabolism of sphingomyelin generates important signals regulating cell proliferation and apoptosis. Previous studies found that the administration of colon carcinoma carcinogen was associated with an accumulation of membrane sphingomyelin, and that dietary sphingomyelin inhibited promotion of experimental colon carcinoma in mice, indicating that the abnormal metabolism of sphingom

We sought to establish the prevalence of lithium-induced end-stage renal disease in two regions of Sweden with 2.7 million inhabitants corresponding to about 30% of the Swedish population. Eighteen patients with lithium-induced end-stage renal disease were identified among the 3369 patients in the general lithium-treated population, representing a sixfold increase in prevalence compared with the g

This paper introduces a research project with the aim to develop concepts and tools for architectural design, taking the ideas of "behaviour settings" as a starting point, to enable a more relevant holistic view in object oriented design of buildings. In this paper we introduce the concept of "architectural object" as a representation of a real "situation" involving people, behaviour, experience a

Established tumour cell lines are ubiquitous tools in research, but their representativity is often debated. One possible caveat is that many cell lines are derived from cells with genomic instability, potentially leading to genotype changes in vitro. We applied SNP-array analysis to an established tumour cell line (WiT49). Even though WiT49 exhibited chromosome segregation errors in 30% of cell d

Popular Abstract in Swedish Vårt immunförsvar måste ständigt vara redo att försvara oss mot angrepp utifrån. Det måste kunna agera selektivt för att skydda oss mot främmande mikroorganismer som virus och bakterier. Om immunförsvaret istället missbedömer kroppens egna celler för att vara inkräktare och attackerar dessa, inträffar det vi kallar autoimmunitet. De autoimmuna sjukdomarna har ökat överaAim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk marke

Osteoporosis is a major health problem affecting more than 75 million people throughout Europe, USA and Japan. Epidemiological studies have determined that both genetic and environmental factors contribute to the pathogenesis of osteoporosis. We have investigated the association between polymorphisms at the osteocalcin locus and variables linked to bone health. Osteocalcin provides a link between

Phobic postural vertigo is characterized by subjective imbalance and dizziness while standing or walking, despite normal values for clinical balance tests. Patients with phobic postural vertigo exhibit an increased high-frequency sway in posturographic tests. Their postural sway, however, becomes similar to the sway of healthy subjects during difficult balance tasks. Posturographic recordings of 3

Cancer patients with advanced disease and short-survival expectancy were given hospital-based advanced home care (AHC) or conventional care (CC), according to their preference. The two groups were compared at baseline to investigate whether there were differences between the AHC and the CC patients that may help explain their choice of care. The patients were consecutively recruited over 2(1/2) ye

Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail

Objective. The aim of the study was to survey existing research about fatigue among older people with chronic non-malignant pain. Method. A structured literature review was carried out using the Medline database. The terms ‘fatigue’ and ‘tiredness’ were used synonymously. These subject headings were combined with pain. A literature search was made in 2004 and included articles back to 1995. Resu

Behovet av hållbara lösningar blir alltmer akut i dagens samhälle, vilket ställer höga krav på vår infrastruktur och dess miljöpåverkan. Det svenska järnvägsnätet uppfyller inte de framtida kraven, och hårda ekonomiska ramar kräver tids- och kostnadsbesparingar för nya infrastrukturprojekt. Vår rapport undersöker hur planeringen av ett höghastighetsspår kan effektiviseras, med fokus på optimering The need for sustainability is increasingly pressing, imposing significant demands on infrastructure and its fossil footprint. The Swedish railway network currently fails to meet future requirements, while new high-speed rail lines struggle to be established. Tight economic constraints necessitate significant time and cost savings to ensure successful project implementation. To take a step closer

Det svenska kontradiktoriska tvistemålsförfarandet bygger på tanken att parterna har det primära ansvaret för att lägga fram bevisning till stöd för sin talan. Ett undantag till den här principen finns i regeln om processuell edition i 38 kap. RB, vilket gör det möjligt för en part att framtvinga skriftliga handlingar som innehas av motparten och kan ha betydelse som bevis i en pågående tvist. FörCivil proceedings under Swedish law are based on the adversarial principle which means that the litigants have the primary responsibility for presenting evidence that supports their case. In Chapter 38 of the Swedish Code of Judicial Procedure there is an exception to this principle. It enables parties in an ongoing civil litigation to gain access to written evidence that is in the possession of t

INTRODUCTION: Plasma biomarkers offer promise for improving the diagnosis of Alzheimer's disease (AD) and differentiating AD and other neurodegenerative disorders (NDs) like frontotemporal dementia (FTD) from primary psychiatric disorders (PPDs), particularly in younger patients. METHODS: In this prospective study, we investigated plasma phosphorylated tau 217 (p-tau217), neurofilament light chain

Background: Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predicted all-cause mortality during 10 years after ischemic stroke. Methods: The study sample comprised 235 patients (median age 74 (interquartile range 25-75% 65-81) years, 95 female)

The European pulp and paper industry (PPI) directly emits 31.9 Mton CO2 (2016) and indirectly 12.3 and 5 Mton CO2 from purchased electricity and transport respectively. It also accounts for 68 Mton of biogenic CO2 emissions. The PPI is a mature industry with overall stagnating market demand in the past ten years and relatively high levels of recycling. Forest countries like Sweden and Finland domi

Background: Lack of a global consensus on the definition of advanced Parkinson’s disease (APD) and considerations for timing of device-aided therapies may result in heterogeneity in care. Objectives: To reach consensus among movement disorder specialists regarding key patient characteristics indicating transition to APD and guiding appropriate use of device-aided therapies in the management of PD

PurposeThe aim of the present study was to identify the most physically demanding work tasks for Swedish ground combat soldiers through the development and application of a questionnaire survey. This is the first in a series of studies aiming to describe the development process and validation of physical selection standards in the Swedish armed forces.MethodsBased on procedural documentation, comb