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Most bacteria with a rod-shape morphology contain an actin-like cytoskeleton consisting of MreB polymers which form helical spirals underneath the cytoplasmic membrane to direct peptidoglycan synthesis for elongation of the cell wall. In contrast MreB of Streptomyces coelicolor is not required for vegetative growth, but has a role in sporulation. Beside MreB, S. coelicolor encodes two further MreB

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra

Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chronic pain (DRCP). Patient-level data were extracted from the national prescriptions

Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between

Slipped-strand mispairing at sites containing so-called coding repeats (CRs) can lead to phase variation of surface proteins in Gram-negative bacteria. This mechanism, believed to contribute to virulence, has so far not been identified in a Gram-positive bacterium. In the genome of the Gram-positive human pathogen Streptococcus pyogenes, we identified pentanucleotide CRs within a putative signal s

The extant mammalian groups Monotremata, Marsupialia and Placentalia are, according to the ‘Theria’ hypothesis, traditionally classified into two subclasses. The subclass Prototheria includes the monotremes and subclass Theria marsupials and placental mammals. Based on some morphological and molecular data, an alternative proposition, the Marsupionta hypothesis, favours a sister group relationship

Men with prostate cancer (n=25) were interviewed, focusing on experiences of micturition problems, indwelling catheter treatment and sexual life consequences. Narrations were found to be practical and technical descriptions rather than emotional, and experiences were described with reduction and negligence regarding personal well-being and the impact of problems. Phenomenological-hermeneutic analy

For how many years was a farmer responsible for running a farm in Sweden’s old peasant society’? This is the question that underpins my research into life in Ramkvilla parish in the province of Småland for two hundred years (1623–1819). By conducting a detailed study of farm practice at the individual level, I have been able to analyse a complex theme that touches upon the issues of responsibility

Embedded computer systems are subject to a multitude of requirements. These include real-time requirements, that is, such computers must respond to external events within limited time. Many systems, such as satellites and telephone switches, must also operate unattended for long periods of time. They must not fail due to defective software. Modern object-oriented programming languages, particular

Popular Abstract in Swedish Hur löser den intellektuelle politikern problem och hur skapas kontakten med den politiska omgivningen? Svaren på frågorna skall kortfattat presenteras och är intressanta för politiker, partier, väljare och forskare. Svaren visar nämligen hur intellektuella politiker under kristider producerar och presenterar innovativa lösningar som kan få stor betydelse för samhällsutA new theory on the intellectual politician, which has the ability to produce a designed type of problem-solving, has been developed from political science theory, cognitive theory as well as art theory. A cognitive concept, modified integrative complexity, consisting of four sub-concepts, frame reflection, differentiation, reframing and integration has been developed. The relation between politic

Världen idag är i ett stort behov av att byta ut fossila råvaror mot mer hållbara alternativ. Nya processer behöver utvecklas för att minska våra utsläpp, bland annat tillverkning av icke fossilbaserade plaster. Plasten polyetylenfuranoat (PEF) har visat stor potential som alternativ till PET, och kan tillverkas av 5-hydroymetylfurfural (HMF). HMF kan bland annat framställas från fruktos, vilket kThe demand for plastics is growing due to global population, economic growth and insufficient recycling, where new bio-based feedstocks must be investigated to meet future emission goals. 5-Hydroxymethylfurfural (HMF) is a promising platform chemical that can produce Polyethylene furanoate (PEF) with similar characteristics to fossil-based polyethylene terephthalate (PET). The HMF can be produced

I uppsatsen undersöks lagregleringen om överskottsinformation vid användning av hemliga tvångsmedel i rättegångsbalken. Överskottsinformation är information som har med annat att göra än den utredning den hemliga tvångsåtgärden användes för. Lagändringen år 2023 innebär att informationen uttryckligen får användas för ”andra ändamål” än den ursprungliga utredningen vilket kan avse brott eller helt The essay examines the legal regulation on excess information when using secret measures of surveillance in the Code of Judicial Procedure . Excess information is information that pertains to matters other than the investigation for which the secret measure of surveillance was used. The 2023 legislative amendment explicitly allows the information to be used for “other purposes” than the original i

Bakgrund: Kulturhistoriska byggnader har ett särskilt historiskt, estetiskt eller socialt värde och skyddas av regler som begränsar förändringar. Med rätt byggnadsvård och tekiska lösningar kan bevarande kombineras med energieffektiviseringar. Även om bevarande ofta innebär högre initiala kostnader, kan det ge långsiktiga värden både kulturellt och ekonomiskt. Syfte: Syftet är ett undersöka hur kThroughout history, construction practices have reflected the materials, knowledge, and economic resources available at the time. These historical characteristics are now seen as cultural assets worth preserving. However, older buildings often fail to meet modern standards, necessitating significant interventions to comply with today’s regulations. This thesis explores the challenges and opportun

PLC-system (Programmable Logic Controller) är robusta realtidssystem som används för att styra fysiska processer i krävande miljöer. Moderna PLC-system är väldigt kapabla, men skulle systemet mot förmodan gå på knä, kan man alltid installera ännu ett PLC-system i mån av plats. En lyx som inte finns ombord på ubåtar, där man istället behöver hushålla med befintliga system. Med hjälp av två matematiThis master’s thesis is commissioned by SAAB Group with the purpose of developing a model which can be used to estimate the margin for expansion of devices in PLC systems. Although commercial PLC systems are hard real-time systems, they have inherited unpredictable characteristics due to off-the-shelves components. This makes it difficult to measure the impact on performance when a new device is c

Denna uppsats undersöker hur fem icke-statliga organisationer (NGO) framställer händelserna kring Sea-Watch 3-fallet sommaren 2019. Räddningsfartyget hölls kvar till havs i över två veckor efter att ha undsatt migranter utanför Libyens kust, utan att någon stat erbjöd en säker hamn. Studien utgår från en kombination av två teoretiska ramverk: normmodellen och liminalitet. Normmodellen används för This thesis examines how five non govermental organisations (NGO) represent the events surrounding the Sea-Watch 3 case in the summer of 2019. The rescue vessel remained at sea for over two weeks after saving migrants off the coast of Libya, without any state offering a safe port of disembarkation. The study draws on a combination of two theoretical frameworks, the norm model and liminality. The n

The Neuregulin-ErbB4 pathway plays a crucial role in brain development and constitutes one of the most biologically plausible signaling pathways implicated in schizophrenia and, to a lesser extent, in bipolar disorder (BP). However, recent genome-wide association analyses have not provided evidence for common variation in NRG1 or ERBB4 influencing schizophrenia or bipolar disorder susceptibility.

Aim: The risk for language disorder is high in children with all levels of hearing loss (HL). Early identification and intervention should be as important for children with mild HL as for those with more severe HL. Despite new-born hearing screening, a recent survey of speech language therapist services in southern Sweden indicates that children with mild and moderate HL are severely neglected whe

Avian migrants may fly at a range of altitudes, but usually concentrate near strata where a combination of flight conditions is favourable. The aerial environment can have a large impact on the performance of the migrant and is usually highly dynamic, making it beneficial for a bird to regularly check the flight conditions at alternative altitudes. We recorded the migrations between northern Europ