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Desensitization with antigen-specific immunoadsorption interferes with complement in ABO-incompatible kidney transplantation

BACKGROUND: Complement activation was characterized during and after desensitization treatment in 19 consecutive patients receiving ABO-incompatible (ABOi) living donor kidney transplants to assess the effect of desensitization protocol including antigen-specific immunoadsorption (IA) on complement activation.METHODS: All patients received rituximab- and tacrolimus-based triple treatment. Anti-A/B

Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels with Retinopathy of Prematurity in Preterm Infants

Importance: Supplementing preterm infants with long-chain polyunsaturated fatty acids (LC-PUFA) has been inconsistent in reducing the severity and incidence of retinopathy of prematurity (ROP). Furthermore, few studies have measured the long-term serum lipid levels after supplementation. Objective: To assess whether ROP severity is associated with serum levels of LC-PUFA, especially docosahexaenoi

Sverige och den västeuropeiska arbetslösheten 1970-1990

This dissertation studies the labor market development of fourteen Western European countries during the years 1970-90, focusing on the relatively low Swedish unemployment. The variation in unemployment over time and between countries has proved difficult to explain with the most influential theoretical models, which are usually categorized as New-keynesian and Post-keynesian respectively. The dis

An Anterior Cruciate Ligament Rupture Increases Levels of Urine N-terminal Cross-linked Telopeptide of Type I Collagen, Urine C-terminal Cross-linked Telopeptide of Type II Collagen, Serum Aggrecan ARGS Neoepitope, and Serum Tumor Necrosis Factor–α

Background: An anterior cruciate ligament (ACL) rupture results in an increased risk of developing knee osteoarthritis (OA) at an early age. Before clinical signs become apparent, the OA process has already been initiated. Therefore, it is important to look at the cascade of changes, such as the activity of cytokines and proteases, which might be associated with the later development of OA. Purpos

Intracavitary Electron FLASH Radiotherapy in a Canine Cancer Patient With Oral Malignant Melanoma

PURPOSE/OBJECTIVE(S): Studies of electron FLASH radiotherapy (FLASH-RT) in companion animals are being conducted at several institutions. High energy electron beams are generally suitable for treatment of superficial cancers, but of limited use for deep-seated tumors. In this case report, the feasibility of intracavitary electron FLASH-RT is demonstrated.MATERIALS/METHODS: A canine cancer patient

Measuring novelty in science with word embedding

Novelty is a core value in science, and a reliable measurement of novelty is crucial. This study proposes a new approach of measuring the novelty of scientific articles based on both citation data and text data. The proposed approach considers an article to be novel if it cites a combination of semantically distant references. To this end, we first assign a word embedding–a vector representation o

Predicting Monthly Community-Level Domestic Radon Concentrations in the Greater Boston Area with an Ensemble Learning Model

Inhaling radon and its progeny is associated with adverse health outcomes. However, previous studies of the health effects of residential exposure to radon in the United States were commonly based on a county-level temporally invariant radon model that was developed using measurements collected in the mid- to late 1980s. We developed a machine learning model to predict monthly radon concentrations

Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity among Preterm Infants

Importance: Circulating levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) are important in the course of brain injury in adults, but longitudinal postnatal circulating levels in preterm infants have not been investigated. Objectives: To examine postnatal longitudinal serum levels of NfL and GFAP in preterm infants during the first 15 weeks of life and to explore possib

Alternative site for the placement of totally implantable vascular access device (TIVAD). A case report of two successful TIVAD implantations in the thigh after femoral vein catheterization

Background: Totally implantable venous access devices (TIVADs) have improved the quality of life for seriously ill and cancer patients. These devices represent a convenient option when long-term venous access is indicated. The Subclavian and Internal Jugular Veins are the vessels of choice for catheterization [1]. However, if it is not possible to catheterize them, an alternative vein should be so

Selective precipitation of calcium ion from seawater desalination reverse osmosis brine

The near zero liquid discharge (NZLD) approach, by recovering water and dissolved valuable salts, is the most attractive clean solution for the valorisation of brines from seawater desalination reverse osmosis (SWD-RO) plants. In this perspective, a key aspect is calcium removal/recovery, to avoid scaling problems in the successive advanced separation units for recovering other valuable salts. In

Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia : a meta-analysis

Background: Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Methods: Literature searches were conducted in Embase, MEDLINE/PubMed,

Surface guided 3DCRT in deep-inspiration breath-hold for left sided breast cancer radiotherapy : implementation and first clinical experience in Iran

Background: The aim of the study is to evaluate the overall accuracy of the surface-guided radiotherapy (SGRT) workflow through a comprehensive commissioning and quality assurance procedures and assess the potential benefits of deep-inspiration breath-hold (DIBH) radiotherapy as a cardiac and lung dose reduction approach for left-sided breast cancer irradiation. Materials and methods: Accuracy and

Health-related quality of life after Nuss procedure for pectus excavatum : A cross-sectional study

OBJECTIVES: Pectus excavatum (PE) can cause both physical and psychosocial symptoms and affect patients' health-related quality of life. Previous international studies have shown that the Nuss procedure increases both self-esteem and body image. The aim of the study was to evaluate the health-related quality of life in patients who have undergone the Nuss procedure for PE. METHODS: The study had a

Neuropsychological outcome after cardiac arrest : results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was

Prognosis after Intensive Care for COPD Exacerbation in Relation to Long-Term Oxygen Therapy : A Nationwide Cohort Study

Decisions to admit or refuse admission to intensive care for acute exacerbations of COPD (AECOPD) can be difficult, due to an uncertainty about prognosis. Few studies have evaluated outcomes after intensive care for AECOPD in patients with chronic respiratory failure requiring long-term oxygen therapy (LTOT). In this nationwide observational cohort study, we investigated survival after first-time

Free PSA and Clinically Significant and Fatal Prostate Cancer in the PLCO Screening Trial

INTRODUCTION: We studied whether adding percent free prostate-specific antigen (%fPSA) to total PSA improves prediction of clinically significant prostate cancer (csPCa) and fatal PCa.METHODS: 6727 men within the intervention arm of the Prostate, Lung, Colorectal and Ovarian Trial had baseline %fPSA. Of this cohort, 475 had csPCa and 98 had fatal PCa. Cumulative incidence and Cox analyses were con

GPs’ experience with diagnosis and treatment guidelines for lower UTI in men: a qualitative interview

Background: The incidence of lower urinary tract infection (LUTI) in men visiting primary health care (PHC) is low. Hence, GPs do not diagnose and treat men with LUTI very often. Previous studies have shown that adherence to treatment guidelines regarding LUTI in men is low. There is limited knowledge concerning why guidelines are not adhered to.Aim: To gain knowledge on GPs’ experiences and conceBackground: The incidence of lower urinary tract infection (LUTI) in men visiting primary healthcare (PHC) is low. Hence, GPs do not diagnose and treat men with LUTI very often. Previous studieshave shown that adherence to treatment guidelines regarding LUTI in men is low. There is limitedknowledge concerning why guidelines are not adhered to.Aim: To gain knowledge on GPs’ experiences and concerns

The effect of equal versus expanding spacing practice on the deliberate learning of L2 collocations

Research comparing equal and expanding spacing schedules in relation to L2 single words is limited. Moreover, none of the existing studies has examined the learning of formulaic language. The current study aims to address this gap by investigating the impact of equal and expanding intervals on the long-term retention of L2 collocations in deliberate learning contexts. Eighty-three university learnResearch comparing equal and expanding spacing schedules in relation to L2 single words is limited. Moreover, none of the existing studies has examined the learning of formulaic language. The current study aims to address this gap by investigating the impact of equal and expanding intervals on the long-term retention of L2 collocations in deliberate learning contexts. Eighty-three university learn