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The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib
The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren′s syndrome. To investigate whether NOD genes also promote autoimmune-mediatedarthritis we established a NOD strain with an MHC class II fragment containing the Aq class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contr
https://rwi.lu.se/news/cop26-rwi-goes-to-glasgow/ - 2026-07-04
https://rwi.lu.se/news-tags/cop26/ - 2026-07-05
Irish as an official language in Northern Ireland: one year after passing the House of Commons - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Educatio
https://rwi.lu.se/blog/irish-as-an-official-language-in-northern-ireland/ - 2026-07-05
Välkommen till LU Lands Kick-off-konferens!Datum & Tid: 27 November 2019, kl 9 - 14Plats: Nya Festsalen, AF Borgen i LundRegistreringen för Kick-off-konferensen är nu stängd, men vill du veta mer eller är intresserad av att delta, skicka ett mejl till juliana [dot] danhardt [at] cec [dot] lu [dot] se. prel_program_vs2.pdf Konferensen anordnas av LU Land (Lunds universitet) i samarbete med SBHub oc
https://www.cec.lu.se/form/anmalan-lu-land-kick-konferens - 2026-07-05
https://rwi.lu.se/young-voices-from-cop26/ - 2026-07-05
Riktlinjer för nyttjande av genetiska resurser och/eller traditionell kunskap FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer för nyttjande av genetiska resurser och/eller traditionell kunskap Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Riktlinjer fastställer hur någon ska eller bör handla inom det område riktlinjerna omfattar. En ska- regel ska följas medan en bör-regel mer har kara
