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Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2

The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth

Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.

Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

Demonstration of antibody‐associated cellular cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy

This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Review of exergy and energy analysis of fuel cells

Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces

Sex differences in presentation of atrial fibrillation : Findings from 30-day ambulatory monitoring in real-world practice

Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients under

Sammantradesdagar-frs-rs-ht-2020

Microsoft Word - Sammanträdesdagar höstterminen 2020.docx LUNDS UNIVERSITET Sammanträdesdagar för förmöten och rektorssammanträden HT 2020 Universitetsledningens kansli (2020-05-28) Johanna Albihn/Anna Åkesson Augusti September Oktober November December Förmöte inför RS (FRS) 11, 18, 25 1, 8, 15, 22, 29 6, 13, 20 3, 10, 17, 24 1, 8, 161 Rektorssammanträde (RS) 13, 20, 27 3, 10, 17, 24 1, 8, 15, 22

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/sammantradesdagar-frs-rs-ht-2020.pdf - 2026-06-12

Cardiovascular biomarkers predict fragility fractures in older adults

Abstract OBJECTIVE To assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures. METHODS We analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal Objective To assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures. Methods We analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal associati

Grundkurs i service management (SEMA11) – kursstart hösten 2026

Studenter som är antagna till den fristående kursen Grundkurs i service management (SEMA11) samlas i U202, Campus Helsingborg, för att hälsas välkommen till Lunds universitet, Campus Helsingborg och till programmet (fristående kursen). På eftermiddagen är det upprop och registrering samt att du träffar kursansvarig lärare och dina studiekamrater. Måndag 31 augustiFöreläsning: Välkommen till dina s

https://www.ses.lu.se/utbildning/grundkurs-i-service-management-sema11-kursstart-hosten-2026 - 2026-06-11

Mouse S-factors based on monte carlo simulations in the anatomical realistic Moby phantom for internal dosimetry

Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phan

Verksamhetsberättelse 2020 För EBSCO Systems Nordic User Group

Verksamhetsberättelse 2020 för EBSCO Systems Nordic User Group Verksamhetsåret 2020 präglades i stort av en global coronaviruspandemi med anledningen av spridningen av SARS-CoV-2 (se mer här: https://sv.wikipedia.org/wiki/Coronaviruspandemin_2019%E2%80%932021). Pandemin innebar för verksamheten att inga fysiska träffar kunde hållas under året. Därför anordnade föreningen endast digitala möten och

https://www.ub.lu.se/sites/ub.lu.se/files/2021-04/Verksamhetsber%C3%A4ttelse%202020%20f%C3%B6r%20EBSCO%20Systems%20Nordic%20User%20Group.pdf - 2026-06-12