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Importance: Neuroprognostication studies are potentially susceptible to a self-fulfilling prophecy as investigated prognostic parameters may affect withdrawal of life-sustaining therapy. Objective: To compare the results of prognostic parameters after cardiac arrest (CA) with the histopathologically determined severity of hypoxic-ischemic encephalopathy (HIE) obtained from autopsy results. Design,

von Willebrand factor (VWF) is a plasma protein that consists of a series of multimers of which the high-molecular-weight VWF multimers are the most potent in platelet adhesion and aggregation. The propeptide of the VWF (VWFpp) is known to be essential in the process of multimer assembly. Genetic studies were performed in a patient with a phenotype of von Willebrand disease (VWD) characterized by

It is a common strategy to predict oncogenes by differential analysis between somatic mutations and background mutations. Most previous methods only utilize mutations in the cancer population to model its background mutation, which have an obvious bias. A recent method, DiffMut, improves this issue by conducting differential mutational analysis with both mutations in the cancer population and the

Gemensamt för alla människor är att vi någon gång måste konfronteras med döden och dess rättsverkningar. Antingen går en släkting till oss bort eller så är det vi själva som har vår bortgång nära förestående. Syftet med denna uppsats är att få ökad kunskap om hur grunderna i den legala arvsordningen skiljer sig åt mellan Sverige och Danmark i olika familjekonstellationer. Utgångspunkten är följandOne day we all must face death and its legal consequences. It is either in our own near future, or a relative may pass away. The aim with this thesis is to learn about the fundamental differences in inheritance law between Sweden and Denmark in different family constellations. The thesis is based on these constellations: Married couples with joint children, married couples with children from a pre

Background: Low-molecular-weight heparin (LMWH) is recommended for thromboprophylaxis in adult intensive care unit (ICU) patients. Despite its widespread use, there is insufficient evidence on the optimal dose, and there appears to be practice variation. Determining the LMWH dosing strategy that most effectively balances the risks of venous thromboembolism (VTE) and bleeding may improve outcomes i

* The ectomycorrhizal fungus Laccaria bicolor has the largest genome of all fungi yet sequenced. The large genome size is partly a result of an expansion of gene family sizes. Among the largest gene families are protein kinases and RAS small guanosine triphosphatases (GTPases), which are key components of signal transduction pathways. * Comparative genomics and phylogenetic analyses were used to e

The spectrum of mutations in the von Willebrand factor (VWF) gene in a Swedish type 1 von Willebrand disease (VWD) population was investigated. To gain more knowledge about the dynamics of VWD mutations, the data were analyzed from a population genetics perspective. The VWF gene was resequenced in 54 Swedish patients diagnosed with type 1 VWD. Fifty-five variable sites were located in exons, 10 in

A century after the Spanish Flu, the COVID-19 pandemic has brought renewed attention to socioeconomic and occupational differences in mortality in the earlier pandemic. The magnitude of these differences and the pathways between occupation and increased mortality remain unclear, however. In this paper, we explore the relation between occupational characteristics and excess mortality among men duri

This paper reports on a case study, which investigated energy management and environmental management at a large-scale research facility. The author used the perspective of the managed personnel rather than the management, the entity or the management system. The focus of the research was on interpretation of work, particularly how employees' perceptions of priorities were affected by management i

Popular Abstract in Swedish Epigenetik handlar om hur avläsning av informationen i arvsmassan kan styras och nedärvas mellan cellgenerationer. Förmågan att kunna ändra genuttrycksmönster som svar på signaler från omgivningen och sedan bibehålla dessa genom efterföljande celldelningar ligger till grund för korrekt funktion av vävnaderna och organen som våra kroppar är uppbyggda av. Samtliga sjukdomPrecise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are

Noroviruses (formerly Norwalk-like viruses) are a major cause of acute gastroenteritis worldwide and are associated with a significant number of nosocomial and food-borne outbreaks. In this study we show that the human secretor FUT2 gene, which codes for an alpha(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infection

Popular Abstract in English N/AAquatic systems worldwide receive large amounts of organic carbon from terrestrial sources. This ‘allochthonous’ organic carbon (AlloOC) affects critical physical and chemical properties of freshwater ecosystems, with consequences for food web structures and exchange of greenhouse gases with the atmosphere. In the boreal region, loadings of AlloOC are particularly high due to leaching from huge or

An optimization procedure has been established aiming to design an integrated thermal protection system (ITPS) with minimum weight. The objective of this research is to establish the procedure and ensure its effectiveness. A corrugated sandwich panel has been chosen as the optimization problem. The ITPS geometric dimensions are considered as the design variables. The objective function is the mass

It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion arti

The way we use computers and mobile phones today requires large amounts of processing of data streams. Examples include digital signal processing for wireless transmission, audio and video coding for recording and watching videos, and noise reduction for the phone calls. These tasks can be performed by stream programs—computer programs that process streams of data. Stream programs can be composed

This master thesis is part of the development of a new industrial machine. The machine is a fully automated transplanting machine for the forest industry and will be used by nurseries around the world. Nurseries grow seedlings and sell them when they have grown enough to be planted in the ground. The machine being developed moves plants from a tray with small cells to a tray with bigger cells. Thi

Handeln med varumärkesförfalskade produkter, som länge har ansetts som en ganska harmlös företeelse som konsumenten varit väl införstådd med, har utvecklats till en väloljad miljardindustri där såväl rättighetsinnehavaren, samhället och konsumenten riskerar att lida skada. De varumärkesförfalskade produkterna består inte längre av dåligt imiterade solglasögon utan av professionellt utformade kopioCounterfeiting has long been considered a rather harmless phenomenon. However, counterfeiting has evolved from a small-scale activity into one on an industrial scale. It has come to pose a serious threat, not only to the interests of the right holder, but to the consumers and the society as a whole. Counterfeit products are no longer just poorly crafted copies of sunglasses; today they are profess

A small wind power plant connected to the grid has been modeled in Modelica/ Dymola and controlled using external controllers written in C++. The small wind power plant consists of three wind power units with a nominal power of 3kW and one grid connection interconnected with an internal DCgrid. All the controls needed for control and optimization for the operation of the individual parts in the pl