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Unequal excess mortality during the Spanish Flu pandemic in the Netherlands

A century after the Spanish Flu, the COVID-19 pandemic has brought renewed attention to socioeconomic and occupational differences in mortality in the earlier pandemic. The magnitude of these differences and the pathways between occupation and increased mortality remain unclear, however. In this paper, we explore the relation between occupational characteristics and excess mortality among men duri

Dirty harry gone global? : On globalising policing and punitive impotence

This chapter focuses on the experiences of powerlessness among police detectives in a global world. Specifically, it discusses how Danish detectives often feel that certain foreign national criminals get away with their crimes with impunity – here not necessarily meaning that criminals are not caught and sentenced. Rather, what increasingly frustrates Danish detectives are their experiences of how

Study on nanocrystalline Cr2O3 films deposited by arc ion plating: II. Mechanical and tribological properties

In this work, the influence of substrate bias voltage on the microhardness, adhesive strength, friction coefficient, and wear rate of AIP Cr2O3 films deposited on AISI 304 stainless steel substrates was investigated systematically. In the meantime, the wear failure mechanism of AIP Cr2O3 films in dry sliding contact was also analyzed and discussed. The results showed that the mechanical properties

The view from below - a management system case study from a meaning-based view of organization

This paper reports on a case study, which investigated energy management and environmental management at a large-scale research facility. The author used the perspective of the managed personnel rather than the management, the entity or the management system. The focus of the research was on interpretation of work, particularly how employees' perceptions of priorities were affected by management i

The effects of a driver assistance system for safe speed and safe distance - A real-life field study

The effects of a driver assistance system for keeping safe speed and safe distance (referred to as SASPENCE) on driver behaviour, reactions and acceptance were evaluated in a test carried out in 2006. Twenty test drivers, recruited by ads, drove two times (once with the system off and once with the system on) in real traffic conditions along a 50 km long test route containing urban and rural roads

Epigenetic and Phenotypic Profiling of Urothelial Carcinoma

Popular Abstract in Swedish Epigenetik handlar om hur avläsning av informationen i arvsmassan kan styras och nedärvas mellan cellgenerationer. Förmågan att kunna ändra genuttrycksmönster som svar på signaler från omgivningen och sedan bibehålla dessa genom efterföljande celldelningar ligger till grund för korrekt funktion av vävnaderna och organen som våra kroppar är uppbyggda av. Samtliga sjukdomPrecise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are

Complex formed in the system hydrophobically modified polyethylene glycol/methylated alpha-cyclodextrin/water. An NMR diffusometry study

In aqueous solutions hydrophobically modified polyethylene glycol (HM-PEG) forms a transient polymer network held together by intermolecular hydrophobic associations. In the present investigation we have used NMR-diffusometry to study how the addition of methylated alpha-cyclodextrin (M-alpha-CD) influences the polymer network. The addit on of M-alpha-CD resulted in an increased mean self-diffusio

A homozygous nonsense mutation (428G -> A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections

Noroviruses (formerly Norwalk-like viruses) are a major cause of acute gastroenteritis worldwide and are associated with a significant number of nosocomial and food-borne outbreaks. In this study we show that the human secretor FUT2 gene, which codes for an alpha(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infection

Comparison of immunohistochemical and biochemical assay of steroid receptors in primary breast cancer - Clinical associations and reasons for discrepancies

Estrogen ( ER) and progesterone receptor (PgR) status was analysed in paraffin-embedded breast cancer material with immunohistochemical (IHC) technique and compared with corresponding analyses in cytosols ( CYT). ER showed the same status (positive/negative) with both methods in 88% of the samples (352/ 402). The concordance was also high for PgR status (81% [321/394]). Besides values near cut-off

Wild-type distributions of seven oral second-line drugs against Mycobacterium tuberculosis

OBJECTIVES: To determine wild-type minimum inhibitory concentration (MIC) distributions for Mycobacterium tuberculosis, as the background data for defining susceptibility breakpoints are limited. METHODS: We determined wild-type MIC distributions of M. tuberculosis using a 96-stick replicator in Middlebrook 7H10 (7H10) medium for ethionamide (ETH), prothionamide, thiacetazone, cycloserine, rifabut

Thermomechanical optimization of lightweight thermal protection system under aerodynamic heating

An optimization procedure has been established aiming to design an integrated thermal protection system (ITPS) with minimum weight. The objective of this research is to establish the procedure and ensure its effectiveness. A corrugated sandwich panel has been chosen as the optimization problem. The ITPS geometric dimensions are considered as the design variables. The objective function is the mass

Frequency- and Phase-Sensitive Magnetomotive Ultrasound Imaging of Superparamagnetic Iron Oxide Nanoparticles

It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion arti

Optimized expression of soluble cyclomaltodextrinase of thermophilic origin in Escherichia coli by using a soluble fusion-tag and by tuning of inducer concentration

Cyclomaltodextrinases are multidomain and often dimeric proteins from the alpha-amylase family (glycoside hydrolase family 13) which frequently have been very difficult to express in active form in Escherichia coli. To express the soluble form of this type of proteins in larger quantities the expression has to be optimized. We have used and combined two strategies to increase the yield of soluble

Efficient Software Implementation of Stream Programs

The way we use computers and mobile phones today requires large amounts of processing of data streams. Examples include digital signal processing for wireless transmission, audio and video coding for recording and watching videos, and noise reduction for the phone calls. These tasks can be performed by stream programs—computer programs that process streams of data. Stream programs can be composed

Understanding Poverty in Cash-crop Agro-forestry Systems : Evidence from Ghana and Ethiopia

This paper examines the linkages between cash-crop income and other dimensions of poverty to interrogate assumptions regarding the relationship between agricultural income and poverty alleviation. The analysis treats poverty as a multi-dimensional and socially disaggregated phenomenon. The paper employs a mixed methods approach to case studies of Ghana and Ethiopia to explore two critical issues.

Positioneringsmodul till omplanteringsrobot för skogsplantor

This master thesis is part of the development of a new industrial machine. The machine is a fully automated transplanting machine for the forest industry and will be used by nurseries around the world. Nurseries grow seedlings and sell them when they have grown enough to be planted in the ground. The machine being developed moves plants from a tray with small cells to a tray with bigger cells. Thi

Den straffrättsliga bedömningen av varumärkesintrång - en utredning av vissa omständigheter vid påföljdsbestämningen

Handeln med varumärkesförfalskade produkter, som länge har ansetts som en ganska harmlös företeelse som konsumenten varit väl införstådd med, har utvecklats till en väloljad miljardindustri där såväl rättighetsinnehavaren, samhället och konsumenten riskerar att lida skada. De varumärkesförfalskade produkterna består inte längre av dåligt imiterade solglasögon utan av professionellt utformade kopioCounterfeiting has long been considered a rather harmless phenomenon. However, counterfeiting has evolved from a small-scale activity into one on an industrial scale. It has come to pose a serious threat, not only to the interests of the right holder, but to the consumers and the society as a whole. Counterfeit products are no longer just poorly crafted copies of sunglasses; today they are profess

Mandatory Disclosure Rules - En analys av SOU 2018:91

Syftet med denna uppsats är att undersöka förslaget att införa en ny form av uppgiftsskyldighet, Mandatory Disclosure Rules, i skatteförfarandelagen. Förslaget består dels av en implementering av EU-direktivet DAC 6, dels av en inhemsk reglering som saknar motsvarighet i DAC 6. Det huvudsakliga syftet med förslaget är att motverka aggressiv skatteplanering. I uppsatsen används den rättsdogmatiska The purpose of this thesis is to review the proposal to introduce a new reporting obligation, Mandatory Disclosure Rules, in the Swedish Tax Procedures Act. The proposal consists partly of an implementation of the EU directive DAC 6, partly of a domestic regulation without parallel in DAC 6. The main purpose of the proposal is to counter aggressive tax planning. In the thesis, the traditional lega