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Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential

Popular Abstract in Swedish Epigenetik handlar om hur avläsning av informationen i arvsmassan kan styras och nedärvas mellan cellgenerationer. Förmågan att kunna ändra genuttrycksmönster som svar på signaler från omgivningen och sedan bibehålla dessa genom efterföljande celldelningar ligger till grund för korrekt funktion av vävnaderna och organen som våra kroppar är uppbyggda av. Samtliga sjukdomPrecise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are

An optimization procedure has been established aiming to design an integrated thermal protection system (ITPS) with minimum weight. The objective of this research is to establish the procedure and ensure its effectiveness. A corrugated sandwich panel has been chosen as the optimization problem. The ITPS geometric dimensions are considered as the design variables. The objective function is the mass

It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion arti

The Siemens gas turbine SGT-800 is the largest industrial gas turbine produced by Siemens Industrial Turbomachinery (SIT) offering a dry low emission (DLE) capability below 15 ppm NOx. It has a very high reliability using an annular combustor system with passive damping and 30 DLE burners. To obtain a greater understanding of the mixing process and the flame dynamics and in order to further reduce

Noroviruses (formerly Norwalk-like viruses) are a major cause of acute gastroenteritis worldwide and are associated with a significant number of nosocomial and food-borne outbreaks. In this study we show that the human secretor FUT2 gene, which codes for an alpha(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infection

* The ectomycorrhizal fungus Laccaria bicolor has the largest genome of all fungi yet sequenced. The large genome size is partly a result of an expansion of gene family sizes. Among the largest gene families are protein kinases and RAS small guanosine triphosphatases (GTPases), which are key components of signal transduction pathways. * Comparative genomics and phylogenetic analyses were used to e

von Willebrand factor (VWF) is a plasma protein that consists of a series of multimers of which the high-molecular-weight VWF multimers are the most potent in platelet adhesion and aggregation. The propeptide of the VWF (VWFpp) is known to be essential in the process of multimer assembly. Genetic studies were performed in a patient with a phenotype of von Willebrand disease (VWD) characterized by

The spectrum of mutations in the von Willebrand factor (VWF) gene in a Swedish type 1 von Willebrand disease (VWD) population was investigated. To gain more knowledge about the dynamics of VWD mutations, the data were analyzed from a population genetics perspective. The VWF gene was resequenced in 54 Swedish patients diagnosed with type 1 VWD. Fifty-five variable sites were located in exons, 10 in

Hur ska vi ta hand om diskvattnet från kolonin? I Malmö finns en lång tradition av koloniträdgårdar som sträcker sig mer än 100 år tillbaka. Användningen av kolonierna har ändrat sig från att vara till för att odla grönskaer och för stadens arbetare att få möjlighet till återhämtning i lugn och hälsosam miljö, till att idag i stort sätt användas som fullt utrustade sommarstugor som familjen bor iPhosphorus and nitrogen causes eutrophication in the lakes and seas. One source for phosphorous and nitrogen is wastewater from households. To reduce the impact to the seas it is important to purify the wastewater sufficient.In my literature study I have investigated if the greywater (wastewater from bath/shower, dish och wash) has any environmental and health influence on the surroundings. I have

Den bild som målas upp av den svenska skogen är ljus. Skogsbruket sägs vara både hållbart och klimatsmart. Vid första anblick verkar bilden också stämma. Eller? Skogen är om omdebatterat territorium. Börjar man skrapa på ytan märker man att mycket av bilden lämnas utanför. Dagens skogsbruk är långt ifrån så ljus som skogsindustrin, och till viss del politiken, vill få det att verka. En allt mer esThe Swedish forestry sector has been dominated by clear-cutting methods for many decades and wood production has been of great importance for the economic development. Forests and its social values have also formed an important basis for the country’s identity with its recreation opportunities. Societal demands on forests are however many and increasing with an escalating climate crisis and the ne

Uppsatsen syftar till att undersöka hur stor möjlighet arbetsgivare på Sveriges arbetsplatser har att styra över sina anställdas utseenden i form av att uppställa utseendekrav samt klädkoder. Arbetsledningsrätten är långtgående i Sverige och ger arbetsgivare rätt att leda och fördela arbetet i sin verksamhet som det behagar dem. Även om arbetsledningsrätten är genomgripande är den inte obegränsad.The purpose of this essay is to establish the extent to which employers in Sweden's workplaces are able to regulate their employees' appearance through the implementation of dress codes and appearance rules. In Sweden, businesses have a fairly broad range of options for how they choose to organize and allocate work inside their organizations. Although the extensive labor management rights

The aim of this study was to research how school counselors work and how they interpret and implement the existing guidelines from Skolverket and Socialstyrelsen. The study is also aimed to investigate what circumstances are influential for the school counselors' ability to implement the guidelines. The method of semi-structured interviews was chosen to allow us to investigate how school couns

Understanding the content of a software project is a complex endeavour. While the Rust programming language promises developers a safer programming language, a program may still include vulnerable code through its dependencies. In this thesis we present a CLI tool, cargo-indicate, to query the dependency tree of Rust projects using standard GraphQL. This tool aggregates data from a variety of sour

The human right violations in Kurdish cities in 90s is the focus point of the Kurdish documentary cinema. Although there are several documentary studies on trauma, little attention has been given to experiences of audiences. The aim of this study is to explore the ways in which the audience engages with the documentary in the context of The Well (Bîr, dir. Veysi Altay, 2018), which is one of the i

Syftet med uppsatsen är att studera vad domstolarna får döma över och vilka värden den svenska straffrätten bygger på. För att undersöka vad domstolarna får döma över har jag behandlat de krav på gärningsbeskrivningens omfattning som ställs i RB 30:3. Därtill undersöks vad lagen och förarbeten behandlar om materiell processledning. För att kunna undersöka straffrättens värden använder jag mig av

Background: Low-molecular-weight heparin (LMWH) is recommended for thromboprophylaxis in adult intensive care unit (ICU) patients. Despite its widespread use, there is insufficient evidence on the optimal dose, and there appears to be practice variation. Determining the LMWH dosing strategy that most effectively balances the risks of venous thromboembolism (VTE) and bleeding may improve outcomes i

Aim: Phantoms are used daily in the clinic for radiotherapy. As more realistic phantoms are requested, 3D printing could be used but the design of a realistic phantom is difficult. The purpose of this project was to design and 3D print an anthropomorphic phantom that could be used for verification of complex treatment such as stereotactic arrhythmic radioablation treatments without the use of pati