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BACKGROUND: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With few exceptions, detailed studies on second generation sulphonylureas in diabetics with impaired renal function are lacking.

Background: Ethiopia is one of the sub-Saharan African countries most affected by the human immunodeficiency virus (HIV) epidemic and also by severe undernutrition, which is particularly prevalent among women. HIV infection, reproductive biology, and their role in society increase the vulnerability of women to malnutrition. Various factors including urbanization could cause differences in the nutr

Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the cli

Background and ObjectivesIdentifying a clinically meaningful change in cognitive test score is essential when using cognition as an outcome in clinical trials. This is especially relevant because clinical trials increasingly feature novel composites of cognitive tests. Our primary objective was to establish minimal clinically important differences (MCIDs) for commonly used cognitive tests, using a

Adolescence is a period of significant physiological changes, and likely a sensitive window to chemical exposure. Few nation-wide population-based studies of chemical body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016–17, over 13 chemical substance groups, including elements, chlorinated/brominated/fluorinated persistent organic polluta

Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabe

Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between s

Introduction: Pelvic girdle pain during and after pregnancy is a major public health problem with significant daily problems for affected women and their families. There is now accumulating evidence that pregnancy-related pelvic girdle pain originates from the sacroiliac joints and the pubic symphysis as well as their extra-articular ligaments. However, the heritability of the disease remains to b

Sverige är sedan 1971 ansluten till FN-konventionen om avskaffande av alla former av rasdiskriminering. Konventionen tillkom som en reaktion mot rasdiskriminerande förtryck i form av apartheid och kolonialism. Varje konventionsstat är enligt konventionens art. 4(b) skyldig att olagligförklara och förbjuda organisationer som främjar och uppmanar till rasdiskriminering. Trots upprepad kritik från In 1971, Sweden ratified the United Nations convention on the elimination of all forms of racial discrimination. It was established as a reaction to racial oppression, such as apartheid and colonialism. All state parties are, under article 4, obliged to prohibit and criminalise organisations who in any way promote or encourage racial discrimination. Sweden has, in spite of criticism from the conve

Att förutsäga framtiden – modellering som ett verktyg för att förutsäga vattenkvantitet och vattenkvalitet Inom 100 år så kommer klimatet förändrats avsevärt om utsläpp av växthusgaser fortsätter i samma takt som idag. Detta kommer påverka temperatur, nederbörd vilka i sin tur påverkar flödet av vatten i Sverige. Ett avrinningsområde består av olika jordtyper, vegetation och topografi, vilka allClimate change will alter the hydrological cycle in the 21st century with implications for the water balance and water quality. As characteristics of the landscape may vary significantly between nearby locations, hydrological models need to be able to delineate responses attributed to specific landscape characteristics, to estimate their responses to altered climatic drivers. Small streams are the

Sverige har beslutat att år 2020 implementera barnkonventionen och konventionen blir då erkänd som svensk rätt. Barnets rätt att komma till tals i alla förfaranden som berör barnet är en grundläggande princip i barnkonventionen. Norge implementerade barnkonventionen år 2003 vilket resulterade i att barnets rättigheter stärktes. Barnets rätt att komma till tals är lagstadgad i föräldrabalken men t

The app-industry today is ruled by two giants, namely Android and iOS. For companies and developers, it is essential to deliver their product to the majority of users, thus adapting to both platforms. The platforms involve their own way of developing applications and only barely resembles each other. A problem that the industry faces resides here, having to hire staff with knowledge in either Andr

Katalysatorer påskyndar en reaktion utan att själva förbrukas; denna mening känner nog många igen från sin skoltid. Andra har hört talas om katalysatorer som något de "har i bilen". Mycket riktigt är det främst i bilar där vi i våra vardagliga liv stöter på katalysatorer. Här används de för att omvandla de mycket giftiga gaserna kolmonoxid och kväveoxid till för människorna ofarligt kvävIn order to fully understand the underlying processes of catalysis, it is vital to combine measurements of the catalyst surface, where the reaction occurs, with measurements of the gas concentration close to the catalyst. We have developed a convenient setup, which uses a single laser system to visualise the gas surrounding a working catalyst in situ at realistic operating conditions. Planar Lase

Examensarbetets titel: Krisen blev en dödsdom för PPM-jätten, vilka lärdomar kan dras av fallet Allra? Forskningsfråga: Hur kommunicerar Allra externt i samband krisen och hur förändras kommunikationen över tid i samband med att krisen eskalerar samt vilka kritiska faktorer i Allras kriskommunikation leder till misslyckande. Syfte: Studiens syfte är att definiera hur Allra kommunicerat under kriTitle: The crisis that became the death-penalty for the PPM-giant, what learnings can be made from the Allra-case? Research question: How did Allra communicate externally during the crisis and how did the communication change over time as the crisis escalated. In addition, what critical factors led to the shortcomings in Allra's crisis communication. Purpose: The study's purpose is to de

Popular science This study describes the development and implementation of a Photo Voltaic (PV)Roof Integration Analysis Tool integrated into a GIS system in order to be used in conducting research within alternative energy field. This study focuses on the Dokki district in Greater Cairo that was used as a case for developing the idea of a tool to assess the possibility of the roofs of existing bu

This master thesis project was performed in collaboration with Johnson Matthey. Johnson Matthey is a worldwide company working with sustainable technologies. The site in Perstorp, where this work was performed, focus on formaldehyde production. In order to continuously improve chemical processes, simulation and modeling are advantageous tools. They can give a better understanding of the processes

The transition from animal-based to plant-based proteins is rapidly increasing because of different concerns about meat consumption, some being the nutritional and environmental effects of meat consumption. During this transition, there needs to be a holistic approach to assessing plant-based food. This master thesis is focused on investigating the nutritional and environmental impact of three pla

Given the current societal and political developments in Germany, the visibility and integration of-marginalized is essential to ensure their inclusion in mainstream society. One way of encouraging-contact between majority and marginalized groups is through building social networks, of which-informal and nonformal educational activities play an important part. This thesis examines the-experience o

Purpose: This thesis analyses and assesses how companies in Germany’s DAX 40 demonstrate their adherence to the UN Sustainable Development Goals. It evaluates whether these disclosures are mainly substantive, indicating proper strategic integration, or symbolic, aimed primarily at enhancing reputation, and compares their reporting quality to previous international research. Methodology: This rese