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Purpose: Usher syndrome is the most common cause of deafness associated with visual loss of a genetic origin. The purpose of this paper is to report very severe phenotypic features of type 1B Usher syndrome in a Saudi family affected by positive homozygous splice site mutation in MYO7A gene. Methods: Affected siblings went through detailed history. Complete ophthalmic examination was done. Imaging

In this letter, we demonstrate low-frequency noise (LFN) characterization of an InAs vertical gate-all-around hafnium-zirconium oxide (HZO) ferroelectric field-effect transistor (FeFET). The LFN characteristics are investigated before and after ferroelectric switching for up to 1000 cycles in the FeFET. The evolution of such cycling reveals distinct differences in the LFN for the two polarization

Purpose: To report the clinical and electrophysiological features of cone dystrophy with supernormal rod response (CDSRR). Methods: Retrospective cohort study of 15 unrelated patients (nine males and six females, median age 16, range 5–47 years) diagnosed with CDSRR by clinical examination, full-field electroretinography (ERG) and genetic testing. Observations: History, ophthalmic examination incl

Objective: Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis. Results: We used information from the Mal

This paper presents a two-phase heuristic methodology aimed at the reconfiguration of a radial distribution network with the objective of minimizing the computational time. In the preliminary phase of the operation, all network switches are in a closed state, and it is proposed that a subsequent switch opening methodology be employed to achieve a configuration that approximates optimal radial char

We present experimentally derived potential curves and spin-orbit interaction functions for the strongly perturbed A (1)Sigma(+)(u) and b (3)Pi(u) states of the rubidium dimer. The results are based on laser-induced fluorescence and optical-optical double-resonance polarization spectroscopy measurements combined with earlier laser-induced fluorescence data. We used an analytic potential (Hannover

The survival of the probiotic strains Lactobacillus reuteri ATCC 55730, Lactobacillus acidophilus DSM 20079 and Bifidobacterium bifidum DSM 20456, all of human origin, were investigated in three different oat-based, non-dairy products (Adavena M40, MG20 and G40). The products were fermented by the three strains with and without the presence of a commercial yoghurt culture (V2). Samples were stored

Future manufacturing systems need to be more flexible, to embrace tougher and constantly changing market demands. They also need to make better use of plant data, ideally utilizing all data from the entire plant. Low-level data should be refined to real-time information for decision making, to facilitate competitiveness through informed and timely decisions. The Line Information System Architectur

This paper presents a holistic approach to perform energy renovations of office buildings. A real case study is used to demonstrate how different software can be used to facilitate the work of architects and engineers during different design stages. Initially, the moisture safety of the building is coupled to its energy performance to define the optimum insulation level. The new interior layout is

Objectives Studies on health effects of tobacco often rely on self-reported exposure data, which is subjective and can lead to misclassification. The aim of this study was to describe the prevalence of cigarette smoking, snus and e-cigarette use, as well as to validate self-reported tobacco use among young adults in Sweden. Method Participants of a population-based Swedish cohort (n=3052), aged 22

Understanding nanoparticle catalysis requires novel approaches in which adjoining crystal orientations can be studied under the same reactive conditions. Here we use a curved palladium crystal and near-ambient pressure X-ray photoemission spectroscopy to characterize chemical species during the catalytic oxidation of CO in a whole set of surfaces vicinal to the (111) direction simultaneously. By s

Background: Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical studies have revealed CGRP antagonistic effects on intracranial arteries (ICA). The aim of the study was to evaluate the in vitro antagonistic effects of frem

APC-resistance is the most common hereditary condition associated with venous thrombosis. It is in a majority of cases due to a single point mutation in the factor V gene (FVR506Q). Currently used functional APC-resistance tests have 85-90% sensitivity and specificity for the FVR506Q mutation. A modified test which includes predilution of patient plasma in factor V depleted plasma has increased th

Paradise Hotel (PH) är Sveriges största och mest populära reality-tv-program, men även kanske Sveriges största kändisfabrik; unga svenskar söker sig nämligen till programmet i hopp om att lansera ett sociala medie-baserat kändisskap. Till att börja med grundar sig PH i heteronormativitet och har ofta blivit kritiserat för förlegade könsroller, därför utgår denna studie från att undersöka de könsst

Lösningsmedel är vätskor i vilka nästan all kemi utspelar sig, såsom tillverk- ningen av kemiska ämnen (t.ex. mediciner), extraktioner av ämnen, eller separationer av olika ämnen. Inom framförallt läkemedelsindustrin används enorma mängder lösningsmedel, vilket är ett stort problem eftersom nästan alla vanliga lösningsmedel är giftiga, miljöfarliga, och brandfarliga. Så kallade gröna lösningsmedelCO2-expanded liquids (CXLs) are a class of solvent systems that have shown great promise as a green and effective medium in synthesis, catalysis, extractions, and analytical separation methods. Unfortunately, not much information is available on the polarity and miscible compositions of CXL systems, information which is crucial for selecting the right solvent system for a particular application. H

The purpose of this thesis is to examine whether active fund management gives higher risk adjusted returns in comparison to index funds. This will be done by the use of three different performance measures, Sharpe ratio, Treynor ratio, and Jensen’s Alpha, the aim is to examine 116 mutual funds in the Swedish fund market over the time period of 2016-2021. By using Ordinary Least Squares, with a dum

Climate change is the biggest challenge of our time. The climate is changing dramatically because of human activity and the construction and property sector plays a key role in reducing climate emissions and building a sustainable future. Although the development of climate-smart solutions in the construction and real estate sector has come a long way, the spread of green buildings has encountered

Global agri-food systems are in urgent need of a sustainability transformation guided by best practices of agroecology. The study used the Tool for Agroecological Performance Evaluation (TAPE) to assess the performance of seven market gardens in southern Sweden in comparison to the Swedish horticultural sector. The findings indicate that all participating market gardens could be considered agroeco

Bi-spectral beam extraction combines neutrons from two different kinds of moderators into one beamline, expanding the spectral range and thereby the utilization of an instrument. This idea can be realized by a mirror that reflects long wavelength neutrons from an off-axis colder moderator into a neutron guide aligned with another moderator emitting neutrons with shorter wavelengths which will be t

Oskarshamn 3 has undergone a power uprate from 110% to 129.1% of original reactor thermal output in recent ended project PULS (Power Uprate with Licensed Safety). The main objective of this thesis have been to identify deviations in the power plant, explaining the differences in power output between designed and achieved power output after PULS. The investigation has been conducted with the use of