Sökresultat

There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen

Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i

Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr

The baobab is among the commonly consumed wild fruits found in the semi-arid regions of sub-Saharan Africa. It has a wide application in food systems and folk medicine and has an advantage of surviving even in harsh environmental conditions. While the fruit pulp is packed with a lot of essential nutrients and has gained much interest in recent past on the international market as a healthy ‘superfo

Activation-induced cytidine deaminase (AID) is an enzyme and key component of both 15 class-switch recombination and somatic hypermutation, two mechanisms used by activated B 16 cells to diversify their antigen repertoire, as it catalyzes the deamination of deoxycytidines turning 17 them into deoxyuridines, introducing mutations in immunoglobulin genes. AID, however, can also 18 target enhancer re

Idiopatisk normaltryckshydrocephalus (iNPH) är en neurologisk sjukdom som påverkar hjärnans vätskecirkulation och kan leda till symtom som gång- och balanssvårigheter, kognitiv nedsättning och urininkontinens. Sjukdomen drabbar omkring 1.5 % av 70-åringar, och prevalensen ökar med åldern. Det är en svårdiagnostiserad sjukdom där hjärnvätska (CSF) ansamlas i hjärnans hålrum, vilket påverkar hjärnanIntroduction: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable but largely underdiagnosed neurological condition affecting the elderly population. It is characterised by gait and cognitive impairment, as well as urinary incontinence. For the most part, it is diagnosed via imaging and clinical assessments. Abnormalities in cerebrospinal (CSF) flow in the cerebral aqueduct have been li

Anesthesiology is the medical specialty dedicated to the relief of pain and care of the surgical patient before, during and after surgery. Most of the work in anesthesiology is routine patient care, but because patients are sick and surgical procedures may develop in unexpected ways, anesthesiology by its nature often involves medical crises. In recent years, two concepts have gained increasing i

Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB

Popular Abstract in Swedish Bröstcancer är den vanligaste dödsorsaken bland cancersjuka kvinnor. Därför rekommenderas regelbundna mammografiska hälsokontroller för tidig diagnostik och snar behandling för att förbättra prognosen. I Sverige rekommenderas kontroller för kvinnor mellan 40-74 år. Mammografiska hälsokontroller medför dock även risker, såsom till exempel behov av kompletterande bröstundOne side-effect of breast cancer (BC) screening is a false-positive mammogram among healthy women. That is, finding(s) on a screening mammogram that lead to additional breast examinations but where the woman is eventually considered free from BC. There is evidence of short-term psychosocial consequences of false-positive BC screening. Regarding long-term consequences, research findings are inconsi

IMPORTANCE: The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.OBJECTIVE: To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.DESIGN, SETTING, AND PARTICIPANTS: Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicab

Att behandla tumörsjukdomar genom injektion av radioaktiva läkemedel är en behandlingsteknik kallad radionuklidterapi. Det radioaktiva läkemedlet består av en radioaktiv isotop, fäst på en målsökande bärarmolekyl, specifik för den vävnad vari man önskar att läkemedlet skall ansamlas. Då den radioaktiva isotopen sönderfaller sänds joniserande strålning ut; strålning med förmågan att jonisera molekyIntroduction: There is a need of reassessment of radiation absorbed dose specification in nuclear medicine, taking the non-uniformities in the distribution of radioactivity into account. This is especially important in radionuclide therapies where very high activities are administered and the radionuclides emit alpha particles, beta particles or low-energy electron and will require absorbed dose c

Abstract in UndeterminedThe capacity of shrub canopy water storage is a key factor in controlling the rainfall interception. Thus, it affects a variety of hydrological processes in water-limited arid desert ecosystems. Vast areas of revegetated desert ecosystems in Northwestern China are occupied by shrub and dwarf shrub communities. Yet, data are still scarce regarding their rainwater storage cap

Background If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. Methods Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised rand

Importance: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date.Objective: To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality.Design, Setting, and Participants: This populatio

Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis

Importance: Better understanding is needed of the degree to which individuals tolerate Alzheimer disease (AD)-like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). Objective: To examine the demographic (age, sex, and educational level), genetic (APOE-ϵ4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could