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The period after birth, when an infant is initially exposed to vast amounts of environmental and microbial antigens, sets the stage for proper immune system development ensuing lifelong immunity. Simultaneous to this first-time exposure, the nursing mother provides immune protection via antibodies in the breast milk. Secretory Immunoglobulin A, as provided by the mother or produced intrinsically i
Introduction: The main purpose of this study was to extract global values of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in healthy volunteers, using magnetic resonance imaging (MRI) phase maps. The repeatability of the method was evaluated, and the age dependences of OEF and CMRO2 were analyzed. Material and methods: Phase data were acquired using a 3T MRI scann
Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available for all lifeforms. Previous computational studies have given widely diverging results regarding the reaction mechanism of the enzyme. For example, some recent studies have suggested that one of the μ2-bridging sulfide ligands (S2B) may dissociate from one of the Fe ions when protonated in the doubly
Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimat
Background: Aggregation of lung cancer (LCa) in family members is well-documented. However, little is known on the familial risk of LCa when first-degree relatives (FDRs, parents or siblings) are diagnosed with LCa as a second primary malignancy (LCa-2). We aimed to investigate whether and to what extent a family history of LCa-2 was associated with an increased LCa risk. Methods: In this Swedish
Objective: To assess the variation in changes in patient-reported outcomes 4 to 6 years after arthroscopic partial meniscectomy (APM).Design:Prospective cohort study.Setting:Orthopedic departments at public hospitals.Patients:Patients (n = 447) from the Knee Arthroscopy Cohort Southern Denmark undergoing APM.Interventions:All patients underwent APM.Main Outcome Measures:Change in KOOS4scores from
Summary: This study describes that low bone density is prevalent in premenopausal Saudi women, especially women of normal weight and vitamin D deficiency. Although BMD is higher in obese young women, this may not be beneficial later in life in conjunction with persistent vitamin D deficiency. Introduction: Not attaining peak bone mass is one crucial factor contributing to the risk of developing os
Objectives: To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries. Design: Retrospective observational study. Setting: ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Patients: Adult patients with ant
Background: About one in ten adults are living with diabetes worldwide. Intake of carbohydrates and carbohydrate-rich foods are often identified as modifiable risk factors for incident type 2 diabetes. However, strong correlation between food variables can make it difficult to identify true associations. The purpose of this study was to identify clusters of carbohydrate-rich foods and analyse thei
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
Background: Electrocardiographic detection of patients with occlusion myocardial infarction (OMI) can be difficult in patients with left bundle branch block (LBBB) or ventricular paced rhythm (VPR) and several ECG criteria for the detection of OMI in LBBB/VPR exist. Most recently, the Barcelona criteria, which includes concordant ST deviation and discordant ST deviation in leads with low R/S ampli
Bakgrund: Fotboll är en av världens största idrotter och i Sverige står fotbollen för ca en tredjedel av den samlade svenska idrottsrörelsen. Andelen damfotbollsspelare ökar ständigt. Man har sett att damfotbollsspelare löper en ökad risk för att drabbas av knäskador och då framförallt främre korsbandsskada. Denna skada är allvarlig då den innebär stora konsekvenser för både spelaren och samhället
Objectives The objective of this Health Technology Assessment was to evaluate effectiveness, complications and cost-effectiveness of surgical or non-surgical treatment for proximal, diaphyseal or distal fractures of the humerus in elderly patients. Secondary objectives were to evaluate the intervention costs per treatment of proximal humerus fractures (PHF) and to investigate treatment traditions
Type 2 diabetes mellitus is associated with an elevated risk of cardiovascular disease, but the mechanism through which diabetes contributes to cardiovascular disease development remains incompletely understood. In this study, we compared the association of circulating regulatory T cells, naïve T cells, effector memory T cells or central memory T cells with cardiovascular disease in patients with
Aim: The use of direct-to-consumer (DTC) telemedicine consultations in primary healthcare has increased rapidly, in Sweden and internationally. Such consultations may be a low-cost alternative to face-to-face visits, but there is limited evidence on their effects on overall healthcare consumption. The aim of this study was to assess the short- and intermediate-term impact of DTC telemedicine consu
H+ projektet i Helsingborg är ett stadsförnyelseprojekt som omfattar den centrala södra delen av staden. Projektet startades år 2002 och merparten förväntas vara bebyggt med bostäder, kontor och offentlig service år 2035. En miljon kvadratmeter mark som tidigare använts som hamn- och industriområde ska utvecklas, förnyas och länkas samman med centrum, söder och omkringliggande områden. Det första
Populärvetenskaplig sammanfattning: Havsnivåförändringar på södra Grönland. Den globala havsnivån har förändrats under den nuvarande mellanistiden främst på grund av fördelningen av vatten mellan hav och glaciärer. Den relativa havsnivån på södra Grönland påverkas också till stor del av jordskorpans anpassning till storleken på det grönländska istäcket. I denna studie presenteras en ny strandförUntil recently there have only been a few observations of relative sea-level change from the inner Bredefjord area in southern Greenland. Here a new sea-level curve is presented from the Tasiusaq area based on data mainly from a sediment sequence from a marine embayment. Sea-level changes can be recorded in sediments as changed chemical composition, physical properties and macrofossil content. Iso
This essay focuses on the increasing problems for companies and right-holders with counterfeited and pirated goods in the European Union and the problems for right holders to enforce their IPR rights. Will IPRED1 make a difference and is there really a need for the new Directive of Enforcement 2004/48/EG, or do the sanctions according to the TRIPS Agreement suffice. Further, IPRED2 is a follow up
Lägg till titel 2023-07-05 Dnr STYR 2022/2735 Förstudie om kompetens- och karriärutveckling för teknisk och administrativ personal En rapport av Åsa Berglund Sammanfattning Denna förstudie har målet att presentera ett beslutsunderlag för hur ett långsiktigt arbete med kompetens- och karriärutveckling för teknisk och administrativ personal kan läggas upp. I förlängningen är målet att långsiktigt sä
