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Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
Machine calibration is important for optimal performance throughout the lifespan of industrial processes. A prime example is the pick-and-place process, where robots must manipulate objects accurately. Currently, this process is manually calibrated, which can be a complex practice. This thesis studies a software-based approach to error detection within the process, aiming to reduce the need for ma
While many industrial processes have been thoroughly exposed to machine learning models, the realm of powder metallurgy is still underexplored. This thesis aims to investigate the potential for a machine learning model to predict the characteristics of metal powders after a reduction annealing process using time series process data from the furnace. A supervised learning model was developed to pre
Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
Universitetslektor Kontaktinformation E-post: ola [dot] mattisson [at] fek [dot] lu [dot] se Telefon: +46 46 222 42 81Organisation Strategi Rumsnummer: Alfa 5,6 rum B427 Hämtställe: 10 WebbplatsOla Mattissons profil i Lunds universitets forskningsportal Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaArtikel i dags- eller nyhetstidningArtikel i fackti
https://www.ehl.lu.se/ola-mattisson - 2026-07-12
Decisions regarding strategic software process improvement (SPI) are generally based on the management's viewpoint of the situation, and in some cases also the viewpoints of some kind of an SPI group. This may result in strategies, which are not accepted throughout the organisation, as the views of how the process is functioning are different throughout the company. This paper describes a method f
Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease driven by persistent fibroblast activation, abnormal epithelial to mesenchymal signaling and excessive extracellular matrix (ECM) remodeling. Better pre-clinical models are needed to reproduce these processes and to support antifibrotic drug development. This thesis tested whether an in vitro co-culture model
