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The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec
Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o
Objective: To evaluate the effectiveness of telemedicine-delivered diet and/or exercise interventions to prevent type 2 diabetes (T2D) in people at risk. Methods: Embase (via Ovid), Medline (via Ovid), Web of Science, CINAHL, Scopus and SciELO were searched from January 2010–December 2020 for intervention studies using a diet and/or exercise intervention delivered through telemedicine for T2D prev
In multiple myeloma (MM), advancements in treatments and toxicity management have enhanced survival rates. This, coupled with shifting age demographics in MM, necessitates an updated assessment of infection risks in MM patients compared to the general population. Using Swedish population-based registries, we investigated the incidence of infections in 8,672 Swedish symptomatic MM patients diagnose
Background: Individuals with diabetes (DM) are often treated with statins, which have a rare side effect: peripheral neuropathy. We aimed to study whether statin treatment affects the risk of carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE) in type 2 DM (T2DM). Methods: We combined multiple national registers in Sweden to identify individuals diagnosed with CTS or UNE in specialized c
Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and
Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le
Aims: The main aim of the present study was to identify factors influencing health-related quality of life (HRQoL), as measured by EQ-5D-5L, in individuals 1 year after the acute phase of COVID-19.Methods: This cross-sectional study included 75 participants (51% females), 1 year after confirmed SARS-CoV-2 infection (76% hospitalised). Associations between HRQoL, measured by patient-reported outcom
Precision oncology is being transformed by the integration of advanced machine learning (ML) methods and extensive biomedical data from genomics, imaging, proteomics, and clinical records. ML techniques, including supervised, unsupervised, deep learning, and reinforcement learning, have progressed from experimental tools to robust systems that identify clinically actionable biomarkers, refine prog
This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu
Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protei
This study presents a comprehensive investigation of the structural, microstructural, electrical, magnetic, and magnetoelectric properties of low-level substitution of Co3 + for Fe3+ ions in the perovskite B-site of BiFeO3 (BiFe1−xCoxO3, x = 0.01, 0.015 and 0.02). X-ray diffraction combined with Rietveld refinement confirms the retention of the rhombohedral R3c structure across all compositions, w
Black carbon (BC) is an air pollutant of emerging concern, and further evidence is needed to understand its health effects. This study investigates the association between gestational BC exposure and birth outcomes, and whether these effects are independent of particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) exposure. We used data from the population-based birth cohort, Maternal
Background: Prenatal exposure to ambient air pollution has been linked to autism spectrum disorder (ASD), but evidence from low-exposure settings such as Denmark remains limited.Objective: We aimed to examine the association between prenatal exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5), black carbon (BC), and nitrogen dioxide (NO2) and ASD in children, and to identify the most
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplex
Discovering topological quantum materials that combine nontrivial topology with large bandgaps and experimentally accessible signatures remains a central pursuit in condensed matter physics. We demonstrate, through first-principles calculations and tight-binding modeling, that pyrite-type osmium disulfide (OsS2) is a fragile topological insulator (FTI) characterized by an exceptionally large direc
BACKGROUND: The EAT-Lancet planetary health diet emphasises plant-based foods while including moderate amounts of animal-sourced foods. Simulation-based modelling studies suggest that the diet can provide adequate micronutrients, but concerns remain about potential deficiencies as studies have used different methodologies and few have assessed nutrient intakes using both dietary and biomarker data
This systematic literature review investigates the relationship between air pollution exposure and inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC). Despite the growing concern over air pollution's impact on various health outcomes, studies specifically addressing effects on the digestive system, particularly IBD, are relatively rare. This review aims
