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BACKGROUND AND OBJECTIVES: Cerebral small vessel disease (CSVD) is associated to cognitive decline and dementia. Neuroimaging changes of CSVD are highly prevalent above 80 years. Only few studies report on incidence of CSVD in high age. We have investigated the incidence and prevalence of magnetic resonance imaging (MRI) markers of CSVD and risk factors in the general older population.METHODS: As
Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients
AIM: To describe sociodemographic disparities in temporal trends of incidence and age distributions of first registered osteoarthritis (OA) diagnosis in southern Sweden.METHODS: We identified all Skåne residents aged 35+ who had lived in the region at any point during the period 2006-2019 with no previous OA diagnosis (ICD-10 codes M15-M19) for 8 years prior to inclusion in the study (n = 849,061)
The Long-Term Global Goal (LTGG) is the focal point for addressing future climate change. This paper explores a specific institutional context: the Structured Expert Dialogue (SED) of the UN Framework Convention on Climate Change (UNFCCC). Set up as a platform for interaction between experts and UN negotiators, the SED is a site where scientific information about the LTGG and net-zero was translat
Background: Research suggests that incident dementia is decreasing, yet researchon secular trends of prodromal dementia such as mild cognitive impairment (MCI) islacking.Methods: To determine change ofMCI prevalence over time and potential explanatoryfactors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)aged 60 and 81 at examination were compared.Results: An overall dr
A generalized approach derived from Bloch's equation of motion of nuclear magnetic moments is presented to model the frequency, magnetic field, spin density, and temperature dependencies in the electromagnetic permeability tensor for materials with magnetic resonances. The resulting tensor model predicts characteristic polarization signatures which can be observed, for example, in Mueller matrix e
We propose controlling the hybridization between Majorana zero modes at the ends of magnetic adatom chains on superconductors by an additional magnetic adatom deposited close by. By tuning the additional adatom's magnetization, position, and coupling to the superconductor, we can couple and decouple the Majorana modes, as well as control the ground-state parity. The scheme is independent of micros
Due to its low symmetry, β-Ga2O3 exhibits a strongly anisotropic optical response. As a result, the absorption spectra change with the polarization state of the incoming photons. To understand this phenomenon, here we calculate the complete electromagnetic wave equation solutions as a function of linear polarization angle and photon energy for β-Ga2O3 using its previously measured complex dielectr
This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in
Background: Despite accumulating evidence of an association between air pollution and renal disease, studies on the association between long-term exposure to air pollution and renal function are still contradictory. This study aimed to investigate this association in a large population with relatively low exposure and with improved estimation of renal function as well as renal injury biomarkers. M
The Common Agricultural Policy (CAP) affects about half of the land area of the EU and allocates close to 40% of the EU’s budget. Consequently, CAP has great potential to guide land management decisions towards multifunctional agricultural landscapes supporting both commodity production and biodiversity. The 2015 “greening” reform was an attempt to increase the multifunctionality of agricultural l
We examined farmers’ costs of providing public goods under the Common Agricultural Policy (CAP) and the expected impacts of the 2015 CAP “greening” reform on regional development and provisioning of public goods. Less than half of CAP spending Before the reform was justifiable in terms of the delivery of specific public goods; and predicted benefits from greening are low. We recommend re-allocatin
Background & Aims: Evidence on the association between physical activity and risk of hepatobiliary cancers is inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cance
In this work, we evaluate the importance of the postmetallization annealing (PMA) temperature on the performance of HfxZr1−xO2-based ferroelectric tunnel junctions (FTJs). Our results indicate a significant difference in tunneling electroresistance (TER) ratio and endurance, depending on the PMA temperature despite negligible variations in remanent polarization. We conclude that the minimization o
Laser-induced Breakdown Spectroscopy (LIBS) is widely applied to the quantitative measurement of gas composition concentrations. However, studies on the effect of gas temperature on LIBS are still lacking. Here, we investigated the effect of gas temperature on LIBS in terms of composition measurements in an air flow field. The air flow field was heated using a resistance wire to different gas temp
Si1−xGex nanowires (NWs) were prepared by gold-supported chemical vapor deposition (CVD) using a single-source precursor with preformed Si–Ge bonds. Besides the tamed reactivity of the precursor, the approach reduces the process parameters associated with the control of decomposition characteristics and the dosing of individual precursors. The group IV alloy NWs are single crystalline with a const
Atomic layer etching (ALE) is a cyclic technique based on self-limiting processes, such as reactive gas adsorption and material removal by low-energy ion bombardment 1,2. In a typical ALE process Ar+ ions with energies of 20-60 eV are used to desorb the reaction products, e.g. SiClx for the Si ALE. Compared to a corresponding continuous reactive ion etching (RIE), where the ion energies often exce
