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Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been
This thesis examines the interactions and role-changings between the LGBTQIA+ community and the creative industries in Guangzhou, China. Following Florida’s (2003) creative capital theory, and Badgett, Waaldijk, and Rodgers’s (2019) study on LGBT inclusion and economic development, involving semi-structured interviews with LGBTQIA+ individuals working or studying in the creative industries. This q
This study focus on the six largest minable cryptocurrencies: Bitcoin, Bitcoin Cash, Litecoin, Ethereum, Monero and DASH, and puts forward determinants that explain large parts of the price value formation in the markets. This is done by Ordinary Least Squares linear regression with intent to validate or question previous research regarding explanatory factors driving the market price. These facto
Vertical agreements cover a wide range of supply and distribution agreements such as exclusive and selective distribution, franchising and agency agreements. Business practice is filled with vertical agreements, and sooner or later any practicing lawyer with a client doing business in or with the EU is likely to be asked to advise on the admissibility of certain restrictions of competition which a
Combinatorial auctions allow buyers to express preferences over bun- dles of items. The Primal-Dual (PD) auction developed by de Vries et al. (2007) is an efficient ascending combinatorial auction which, given certain conditions on buyers valuations, achieves Vickrey-Clarke-Groves (VCG) payments. The Universal Competitive Equilibrium (UCE) auction by Mishra and Parkes (2007) is a generalization of
In this master’s thesis I will investigate how librarians think about how their profession is affected by and relates to the democratic mission and various cultural policy decisions. I will also attempt to make more clear how librarians interpret, relate and deal with external forces of change such as technology, politics and other social forces. This has been done to investigate and survey the tw
Sustainability reporting has become the primary measure of corporate sustainability in the EU, with increasing awareness among companies about the importance of disclosing sustainability matters. Concurrently, the European Union has enacted several pieces of legislation regarding sustainability reporting, notably the Corporate Sustainability Reporting Directive. While blockchain technology initial
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestr
Nanoparticles interfere with protein amyloid formation. Catalysis of the process may occur due to increased local protein concentration and nucleation on the nanoparticle surface, whereas tight binding or a large particle/protein surface area may lead to inhibition of protein aggregation. Here we show a clear correlation between the intrinsic protein stability and the nanoparticle effect on the ag
Abstract in UndeterminedSpatial data clearinghouses are one of the key features of a spatial data infrastructure (SDI). However, recent research indicates that few national clearinghouses function well, as the spatial data resources available cannot be satisfactorily accessed or optimally used. To improve the functionality, we propose that clearinghouses to be complemented with expert systems and
Predicting potential pollination services of wild bees in crops requires knowledge of their spatial distribution within fields. Field margins can serve as nesting and foraging habitats for wild bees and can be a source of pollinators. Regional differences in pollinator community composition may affect this spill-over of bees. We studied how regional and local differences affect the spatial distrib
Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cance
Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.
Background & Aims: The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated. The aim of this study was to investigate the effect of the PNPLA3 I148M mutation on: (1) hepatic secretion of very low density lipoproteins (VLDL) in humans; and (2) secretion of apolipoprotein B (apoB) from McA-RH 7777 cells
BRAF and NRAS mutations are frequently found in melanoma tumours and recently developed BRAF targeted therapies demonstrate significant clinical benefit.
We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with similar to 2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies compris
