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Homeostasis of short-lived blood cells is dependent on rapid proliferation of immature precursors. Using a conditional histone 2B-mCherry-labeling mouse model, we characterize hematopoietic stem cell (HSC) and progenitor proliferation dynamics in steady state and following several types of induced stress. HSC proliferation following HSC transplantation into lethally irradiated mice is fundamentall
Vitamin D, PTH och kalcium i relation till Prostata Cancer
PURPOSE: Epidemiological studies suggest that low levels of vitamin D constitute a risk factor for prostate cancer. However, the results are conflicting, perhaps because prostate cancer is a very heterogeneous disease. More recent studies have focused on cancer progression and mortality. Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three fac
The development of quantum simulators, artificial platforms where the predictions of many-body theories of correlated quantum materials can be tested in a controllable and tunable way, is one of the main challenges of condensed matter physics. Here we introduce artificial lattices made of lead halide perovskite nanocubes as a new platform to simulate and investigate the physics of correlated quant
Purpose: In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866). Methods: We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to
Empowerment has been a key conceptual underpinning of participatory health research (PHR), both as a set of processes that inform how partners and diverse stakeholders engage with each other, as well as a set of outcomes that contribute to improved health and social equity. The concept of empowerment is present in a number of characteristics of PHR as described in Position Paper No. 1 of the ICPHR
Solutions of macromolecules exhibit viscoelastic properties and unlike Newtonian fluids, they may break time-reversal symmetry at low Reynolds numbers resulting in elastic turbulence. Furthermore, under some conditions, instead of the chaotic turbulence, the result is large-scale waves in the form of cyclic spatial and temporal concentration variations, as has been shown for macromolecular DNA flo
Background: Estimating excess mortality and years of life lost (YLL) attributed to coronavirus disease 19 (COVID-19) infection provides a comprehensive picture of the mortality burden on society. We aimed to estimate the impact of the COVID-19 pandemic on age- and sex-specific excess mortality and YLL in Sweden during the first 17 months of the pandemic. Methods: In this population-based observati
INTRODUCTION. In the US, opioids are commonly prescribed after arthroscopic knee surgery. We aimed to investigate opioid dispensing in relation to arthroscopic knee surgeries from 2006 to 2018 in Denmark. METHODS. In Danish registries, we identified patients (≥ 15 years old) having arthroscopic knee surgery (anterior cruciate ligament (ACL) reconstruction; meniscal surgery; cartilage resection; sy
We present a novel method that provides a measurement of DNA pressure in viral capsids using small angle X-ray scattering (SAXS). This method, unlike our previous assay, does not require triggering genome release with a viral receptor. Thus, it can be used to determine the existence of a pressurized genome state in a wide range of virus systems, even if the receptor is not known, leading to a bett
Recent studies indicate that monitoring only fine particulate matter (PM2.5) may not be enough to understand and tackle the health risk caused by particulate pollution. Health effects per unit PM2.5 seem to increase in countries with low PM2.5, but also near local pollution sources (e.g., traffic) within cities. The aim of this study is to understand the differences in the characteristics of lung-
148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertaintie
While research indicates that indoor lighting, exposure to daylight, physical activity, and sleep interact to influence functioning, mood, and daily rhythm, strategies are needed to support behavioral changes among older adults who often spend more time at home after retirement. The objective was to design a web-based course to encourage behavior change related to light, activity, and sleep. GrounWhile research indicates that indoor lighting, exposure to daylight, physical activity, and sleep interact to influence functioning, mood, and daily rhythm, strategies are needed to support behavioral changes among older adults who often spend more time at home after retirement. The objective was to design a web-based course to encourage behavior change related to light, activity, and sleep. Groun
We theoretically investigate a supersolid structure taking the form of stacked, disk-shaped superfluid droplets connected via a dilute superfluid, in an antidipolar condensate. A phase diagram is determined for varying the particle number and scattering length, identifying the regions of a regular dipolar superfluid, supersolid stacks, and isolated stacked disk-shaped droplets in an experimentally
Recent experimental advances have made it possible to detect individual quantum jumps in open quantum systems, such as the tunneling of single electrons in nanoscale conductors or the emission of photons from nonclassical light sources. Here, we investigate theoretically the statistics of photons emitted from a microwave cavity that is driven resonantly by an external field. We focus on the differ
This work describes the rational design of thin film-based cadmium selenide quantum dots (CdSe) mixed with conductive polyvinylidene fluoride (PVDF), inducing PVDF-CdSe composite for potential resistive humidity-sensing applications. The effect of UV/ozone treatment on surface hydrophilicity and sensing properties was investigated. AFM has been performed to examine the prepared films' texture, dis
The resonance between an electronic transition of a micro/nanoscale object and an incident photon flux can modify the radiation force exerted on that object, especially at an interface. It has been theoretically proposed that a non-linear stimulated emission process can also induce an optical force, however its direction will be opposite to conventional photon scattering/absorption processes. In t
Background: Snacking is a common diet behaviour which accounts for a large proportion of daily energy intake, making it a key determinant of diet quality. However, the relationship between snacking frequency, quality and timing with cardiometabolic health remains unclear. Design: Demography, diet, health (fasting and postprandial cardiometabolic blood and anthropometrics markers) and stool metagen
In nanoscale systems coupled to finite-size reservoirs, the reservoir temperature may fluctuate due to heat exchange between the system and the reservoirs. To date, a stochastic thermodynamic analysis of heat, work, and entropy production in such systems is, however, missing. Here we fill this gap by analyzing a single-level quantum dot tunnel coupled to a finite-size electronic reservoir. The sys
OBJECTIVES: This study aimed to investigate the etiology, clinical features, and outcomes of community-acquired pneumonia (CAP) in adults. Understanding the causative pathogens is essential for effective treatment and prevention.DESIGN: Between 2016-2018, 518 hospitalized adults with CAP and 241 controls without symptoms were prospectively enrolled. Urine samples were collected for pneumococcal ur
