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The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these proc
Background Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of olaparib alone in women with BRCA1 or BRCA2 mutations and advanced breast cancer. M
Popular Abstract in Swedish Under det senaste decenniet har risker med och alternativ till allogent blod (blod från främmande givare) debatterats mycket pga. risken för smitta, allergiska reaktioner, samt starka indicier som talar för att blod från främmande givare kan påverka immunförsvaret hos mottagaren. Därför vill man gärna begränsa mängden tillfört givarblod under kirurgiska ingrepp på barn,In children, it is often desirable to minimize allogenic blood transfusion, and this thesis explores the physiology of an alternative method of managing perioperative blood loss: hemodilution with Ringer´s dextran. Methods Clinical studies: Arterial pressure, superior caval venous oxygen saturation (ScvO2) and blood lactate concentration (L) were studied during bone marrow harvesting (BMH) on 23
Bokens första del består av tio längre artiklar, skrivna av forskare och utbildare från olika discipliner. De baseras på forsknings- och utvecklingsprojekt som pågått under de gångna fem åren. I bokens andra del har vi samlat några röster från syntolkningsområdet i stort, framför allt från aktörer utanför den akademiska sfären. Vår ambition är att genom forskning öka förståelsen för syntolkning oc
About ontological rooms in Lars Gustafssons novel Tjänarinnan (1996).
The aim of this paper is to investigate the challenges associated with the industrial implementation of generative design systems. Though many studies have been aimed at validating either the technical feasibility or the usefulness of generative design systems, there is, however, a lack of research on the practical implementation and adaptation in industry. To that end, this paper presents two cas
Chloride and bromide anations of PdX(H2O)3+, cis-PdX2(H2O)2 and trans-PdX2(H2O)2, acid hydrolyses of PdX3H2O−, cis-PdX2(H2O)2 and trans-PcX2(H2O)2, X = Cl, Br, have been studied at different temperatures by means of a stopped-flow technique. Rate constants and activation parameters are given. The palladium complexes react about 5×104 to 5×105 times faster than the analogous platinum(II) complexes.Chloride and bromide anations of PdX(H2O)3+, cis-PdX2(H2O)2 and trans-PdX2(H2O)2, acid hydrolyses of PdX3H2O−, cis-PdX2(H2O)2 and trans-PcX2(H2O)2, X = Cl, Br, have been studied at different temperatures by means of a stopped-flow technique. Rate constants and activation parameters are given. The palladium complexes react about 5×104 to 5×105 times faster than the analogous platinum(II) complexes.
BACKGROUND: Suggestive interventions such as hypnosis and therapeutic suggestions are frequently used to alleviate surgical side effects; however, the effectiveness of therapeutic suggestion intervention has not yet been systematically evaluated. In the present study, we tested the hypotheses that (1) suggestive interventions are useful for reducing postoperative side effects; (2) therapeutic sugg
Economies in transition (EiTs) (e. g. Ukraine (UA), Belarus, Lithuania (LU), Moldova, etc.) face broad needs for energy security enhancement, energy diversification, revitalisation of agriculture and improvements in the state of the environment. Development of national bioenergy potentials can contribute to delivering solutions to these problems. However, EiTs face technical, political, financial,
This paper presents and discusses hitherto unexplored primary sources from the Spanish Civil War archive in Salamanca on the relations between the two largest anarcho-syndicalist organizations in the 1930s, namely Swedish SAC and Spanish CNT. The study shows how these organizations understanding and solidarity with each other,and discusses the traces the ideological contradictions of contemporary
