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High-order interactions associated with non-small cell lung cancer (NSCLC) survival may elucidate underlying molecular mechanisms and identify potential therapeutic targets. Our previous work has identified a three-way interaction among pack-year of smoking (the number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked) and two DNA methylation probes (cg0
OBJECTIVES: Small extracellular vesicles (EVs) contain various signaling molecules, thus playing a crucial role in cell-to-cell communication and emerging as a promising source of biomarkers. However, the lack of standardized procedures impedes their translation to clinical practice. Thus, we compared different approaches for high-throughput analysis of small EVs transcriptome.METHODS: Small EVs w
BACKGROUND AND AIM: Warming temperature promotes bacterial growth while extreme precipitation enhances fecal-oral route of exposures to these pathogens, particularly in resource limited settings, increasing burden of diarrheal diseases. Given climate change related increases in frequency of extreme events, there is a pressing need to develop meaningful early warning system with adequate lead time
This deliverable reports on Risk Assessment for Wetland Sediment Applications on Agricultural Land. The main content is a thorough and critical evaluation (literature review) of the wetland coupled agriculture and the related concerns such as nutrients, sediments and contamination risks. This will also be supported by the two case studies. Constructed wetlands act as traps for substances carried w
Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli
Manufacturing is an industry in which the effects of globalization are obvious. Manufacturing costs are a key factor in this respect and affect, for example, decisions about offshoring, i.e., moving production abroad. If Sweden and other Western countries are to maintain large manufacturing sectors, they must be competitive, making cost one of the most critical parameters. The work presented here
Using simple waves and six-vector formalism, the propagation of electromagnetic waves in nonlinear, bianisotropic, nondispersive, homogeneous media is analyzed. The Maxwell equations are formulated as an eigenvalue problem, whose solutions are equivalent to the characteristic directions of the wave front. Oblique incidence of plane waves in vacuum on a half space of nonlinear material is solved, g
Methane is a powerful greenhouse gas and growing concern regarding global climate changes over the last years has pointed out the need to quantify and control the leaking of methane into the atmosphere. Landfill gas is regarded as one of the major sources for methane migration to the atmosphere. In this study we present research work with the objective to evaluate the use of geoelectrical resistiv
