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We have designed and synthesized a new series of azapeptides which act as potential inhibitors of cathepsin B and/or cathepsin K. Their structures are based upon the inhibitory sites of natural cysteine protease inhibitors, cystatins. For the synthesized azapeptides, the equilibrium constants for dissociation of inhibitor-enzyme complex, K-i, were determined. Comparison of these values indicated t
Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)
This paper aims to identify and review new and unproven emergency department (ED) methods for improved evaluation in cases of suspected acute coronary syndrome (ACS). Systematic news coverage through PubMed from 2000 to 2006 identified papers on new methods for ED assessment of patients with suspected ACS. Articles found described decision support models, new ECG methods, new biomarkers and point-
Anti-HCV prevalence in treated hemophiliacs, their heterosexual partners, intravenous drug addicts and homosexual men was studied. In hemophiliacs and many of the intravenous drug addicts, greater than or equal to 2 sera drawn 1-18 or 1-17 years apart were available. Anti-HCV testing was performed by ELISA (Ortho). Among patients with severe and moderate hemophilia A, 87% (98/112) were positive fo
Ett antal försök på olika typer av sandwichpaneler har genomförts. De valda sandwichpanelerna inkluderar de vanligaste kärnmaterialen. Två olika fullskaletester har genomförts. En av dem var utförd enligt ISO 9705 d.v.s. försök där panelerna var monterade inuti ett obrännbart rum. Det andra sättet av fullskaletesten var utförd genom att använda ett fristående rum under en stor kalorimeter. Denna kSummary : A number of tests have been performed on different types of sandwich panels. The chosen sandwich panels included most common core materials. Two types of full-scale tests were performed. One set was conducted according to ISO 9705 i.e. tests where the panels were mounted inside a non-combustible room. Another set of full-scale tests was performed using a free standing room under a large
Background No data exist regarding mortality rate in young patients with a first-time anterior shoulder dislocation. A cohort of 255 patients aged 1240 years had a primary anterior shoulder dislocation during the years 1978 and 1979. After 10 years, 9 of the patients had died-which is a high figure for this cohort of patients. The question thus arose as to whether these patients had an increased m
By putting emphasis on applications in two basic statistics courses for chemistry students and chemical engineering students we have enhanced student motivation and increased student activity. In addition to a traditional in-class exam, the students complete a take-home project where statistical problems relevant to chemists are discussed. We give several examples of the course and project materia
The interregional traveller’s preferences of railway stations, their service provision and location, are of interest in the discussion of station reinvention brought on by the introduction of high speed train traffic. A railway station is created by station as well as societal agents, and can be described as a synthesis of symbolic value, location, traffic, services and stationscape. Traveller pr
A straightforward semi-implicit finite-difference method approximating a system of conservation laws including a stiff relaxation term is analyzed. We show that the error, measured in L-1, is bounded by O(root Delta t) independent of the stiffness, where the time step Delta t represents the mesh size. As a simple corollary we obtain that solutions of the stiff system converge toward the solution o
A new, 1-step, enzyme-linked immunoassay kit for detection of Group A Streptococci (GAS) in throat samples (QuickVue In-Line One-Step Strep A Test; Quidel Corporation, San Diego, CA) was evaluated for use in a study comprising 536 patients in 8 primary healthcare centres. Compared to conventional culture at the clinical microbiology laboratory, the sensitivity achieved was 73.9% and the specificit
The uptake of nutrients from deep soil layers has been shown to be important for the long-term nutrient sustainability of forest soils. When modelling nutrient uptake in forest ecosystems, the nutrient uptake capacity of trees is usually defined by the root distribution. However, this leads to the assumption that roots at different soil depths have the same capacity to take up nutrients. To invest
Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gen
Purpose: Desmopressin is a well established and effective therapy for nocturnal enuresis. Water intoxication leading to hyponatremia is an infrequent but serious adverse event associated with desmopressin. We assessed the safety of desmopressin in children 18 years or younger with nocturnal enuresis with a focus on the relative safety of the oral compared with the intranasal formulation. Materials
The adoption of the International Convention on Civil Liability for Bunker Oil Pollution Damage 2001 plugs a gap in the otherwise comprehensive international liability and compensation regime for ship-source pollution. Although liability for bunkers pollution from tankers was partially regulated by other civil liability regimes, bunker spills pollution from other types of vessels was left uncovere
